Highly repeatable synthesis of nHA with high aspect ratio

Song, Chen; Pujari-Palmer, Shiuli; Rubino, Stefano; Westlund, Viktoria; Ott, Marjam Karlsson; Engqvist, Håkan; Xia, Wei

doi:10.1016/j.matlet.2015.06.086

Cited by 12 publications

(6 citation statements)

References 19 publications

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“…Hydroxyapatite is generally synthesized by chemical methods using calcium hydroxyde or nitrate as precursors [7]. In recent years, synthesis of nano-structures using natural sources or wastes such as egg shell, fish scale or bovine bone has became an important topic.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of aptamer immobilization using egg shell-derived nano-sized spherical hydroxyapatite for thrombin detection in neuroclinic

Derkuş

Arslan

Emregül

et al. 2016

Talanta

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Section: Introductionmentioning

confidence: 99%

Enhancement of aptamer immobilization using egg shell-derived nano-sized spherical hydroxyapatite for thrombin detection in neuroclinic

Derkuş

Arslan

Emregül

et al. 2016

Talanta

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“…A thicker capsule thickness correlates to an increased inflammation. The fiber particle aspect ratio was the greatest, with a 20 to 50 fold greater particle length than width [32]. Studies have shown that fiber length and diameter are important factors in acute inflammation [57].…”

Section: Discussionmentioning

confidence: 99%

“…The hydroxyapatite nanoparticles (HANPs) with morphologies including dots, sheets, long rods and fibers were fabricated as described below [32].…”

Section: Particle Preparationmentioning

confidence: 99%

In vivo and in vitro evaluation of hydroxyapatite nanoparticle morphology on the acute inflammatory response

et al. 2016

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In vivo and in vitro evaluation of hydroxyapatite nanoparticle morphology on the acute inflammatory response. AbstractBiomedical implants have been widely used in bone repair applications. However, nanosized degradation products from these implants could elicit an inflammatory reaction, which may lead to implant failure. It is well known that the size, chemistry, and charge of these nanoparticles can modulate this response, but little is known regarding the role that the particle's morphology plays in inducing inflammation. The present study aims to investigate the effect of hydroxyapatite nanoparticle (HANPs) morphology on inflammation, in-vitro and in-vivo. Four distinct HANP morphologies were fabricated and characterized: long rods, dots, sheets, and fibers. Primary human polymorphonuclear cells (PMNCs), mononuclear cells (MNCs), and human dermal fibroblasts (hDFs) were exposed to HANPs and alterations in cell viability, morphology, apoptotic activity, and reactive oxygen species (ROS) production were evaluated, in vitro. PMNCs and hDFs experienced a 2-fold decrease in viability following exposure to fibers, while MNC viability decreased 5-fold after treatment with the dots. Additionally, the fibers stimulated an elevated ROS response in both PMNCs and MNCs, and the largest apoptotic behavior for all cell types. Furthermore, exposure to fibers and dots resulted in greater capsule thickness when implanted subcutaneously in mice. Collectively, these results suggest that nanoparticle morphology can significantly impact the inflammatory response.

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“…Яичная скорлупа, один из основных продуктов отходов пищевой промышленности, является хорошим источником карбоната кальция (95%), и этот источник может быть использован для синтеза ГАП. Существуют различные исследования, связанные с синтезом ГАП с использованием скорлупы яиц [16][17][18]. Настоящее исследование также описывает синтез ГАП с использованием этого источника.…”

Section: Introductionunclassified

Синтез Гидроксиапатита Кальция И Его Применение Для Получения Билогически Растворимых Матриц На Основе Полимерных Волокон

Чекиева¹,

Даулбаев²,

Султанов³

et al. 2020

Горение и Плазмохимия

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В данной работе рассматривается возможность синтеза гидроксиапатита кальция (ГАП) с использованием биогенных источников карбоната кальция, а именно кальцита в скорлупе куриного яйца. Порошки ГАП были синтезированы методом осаждения из водного раствора. Данный метод синтеза позволил получить порошки ГАП с чистотой 95%. В ходе экспериментальных работ было обнаружено, что время обработки ультразвуком обеспечивает частицам однородности больше, чем длительная термообработка. Синтезированный порошок ГАП был применен для получения биологически растворимых пленок на основе полимерных волокон. Пленки были получены методом электроформирования. В раствор пленок в разных концентрациях был добавлен лекарственный препарат, в частности амоксициллин. Экспериментальные работы показали, что толщина пленок зависит от концентрации лекарственного вещества. Сканирующая электронная микроскопия (SEM) и рентгеновская дифракция (XRD) были применены для исследования характеристик ГАП и пленок.

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Highly repeatable synthesis of nHA with high aspect ratio

Cited by 12 publications

References 19 publications

Enhancement of aptamer immobilization using egg shell-derived nano-sized spherical hydroxyapatite for thrombin detection in neuroclinic

Enhancement of aptamer immobilization using egg shell-derived nano-sized spherical hydroxyapatite for thrombin detection in neuroclinic

In vivo and in vitro evaluation of hydroxyapatite nanoparticle morphology on the acute inflammatory response

Синтез Гидроксиапатита Кальция И Его Применение Для Получения Билогически Растворимых Матриц На Основе Полимерных Волокон

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