Highly Reproducible Surface-Enhanced Raman Scattering Detection of Alternariol Using Silver-Embedded Silica Nanoparticles

Hahm, Eunil; Kim, Chongam; Pham, Xuan‐Hung; Jun, Bong‐Hyun

doi:10.3390/s20123523

Cited by 18 publications

(20 citation statements)

References 23 publications

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“…The last class of biological pollutant we have discussed here is mycotoxins, which pose a significant threat to human and environmental health due to their toxic properties and ability to persist in a wide variety of environments. Previous studies have used substrates, such as thin‐film PDA‐coated silver nanocubes, 240 silver‐embedded silica nanoparticles, 241 and AuNRs, 242 to detect mycotoxins with high sensitivity and reproducibility. More promising, though, is the use of aptamer‐based platforms, which have successfully been applied to detect multiple classes of mycotoxins 239,244–247 .…”

Section: Discussionmentioning

confidence: 99%

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Applications of surface‐enhanced Raman spectroscopy in environmental detection

Terry

Sanders

Potoff

et al. 2022

Analytical Science Advances

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As the human population grows, the anthropogenic impacts from various agricultural and industrial processes produce unwanted contaminants in the environment. The accurate, sensitive and rapid detection of such contaminants is vital for human health and safety. Surface-enhanced Raman spectroscopy (SERS) is a valuable analytical tool with wide applications in environmental contaminant monitoring. The aim of this review is to summarize recent advancements within SERS research as it applies to environmental detection, with a focus on research published or accessible from January 2021 through December 2021 including early-access publications. Our goal is to provide a wide breadth of information that can be used to provide background knowledge of the field, as well as inform and encourage further development of SERS techniques in protecting environmental quality and safety. Specifically, we highlight the characteristics of effective SERS nanosubstrates, and explore methods for the SERS detection of inorganic, organic, and biological contaminants including heavy metals, pharmaceuticals, plastic particles, synthetic dyes, pesticides, viruses, bacteria and mycotoxins. We also discuss the current limitations of SERS technologies in environmental detection and propose several avenues for future investigation. We encourage researchers to fill in the identified gaps so that SERS can be implemented in a real-world environment more effectively and efficiently, ultimately providing reliable and timely data to help and make science-based strategies and policies to protect environmental safety and public health.

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Section: Discussionmentioning

confidence: 99%

“…Another highly reproducible method was developed by Hahm et al. using silver‐embedded silica nanoparticles for the detection of alternariol (AOH) 241 . This method had a higher LOD in the nanomolar range, but the reproducibility was higher (lower RSD) than the Ag NC@PDA method.…”

Section: Analytes Of Interestmentioning

confidence: 99%

Applications of surface‐enhanced Raman spectroscopy in environmental detection

Terry

Sanders

Potoff

et al. 2022

Analytical Science Advances

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“…[54] Possible small red and blueshifts of the published Raman modes compared to those detected in the current research can be attributed to a different wavelength of the incident illumination and the localized plasmon resonance's optical properties of the substrate. [51,55] It should be noted that none of the existing publications presented Raman data of the analyte at concentrations within ppb levels, which is extremely important in the case of highly hazardous substances such as mycotoxins; in general, mycotoxins are harmful at ppm levels of uptake. Thus, it is a priority to develop an approach which can detect and differentiate mycotoxins at the lowest possible concentrations.…”

Section: Sers Study Of Mycotoxins and Spectra Elaborationmentioning

confidence: 99%

Label‐Free Mycotoxin Raman Identification by High‐Performing Plasmonic Vertical Carbon Nanostructures

Santhosh

Shvalya

Modić

et al. 2021

Small

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starts with aflatoxins (AFs) where aflatoxin B 1 (AFB 1 ) occupies a leading position as the most potent natural carcinogen. [1] The rest are considered less toxic; nevertheless, their ingestion can still lead to serious health-related complications, especially with long-term exposure and consequent accumulation in living organisms. Mycotoxins such as fumonisins, zearalenone (ZEN), trichothecenes, and alternariol mycotoxins induce many different toxicities, including genotoxicity, mutagenicity, neurotoxicity, hepatotoxicity, immunosuppression, and endocrine disruption. [2,3] Many mycotoxins induce toxicity at ppm levels, whereas AFs are already dangerous at ppb levels. Such low concentrations pose a problem as it is extremely challenging to detect and distinguish between different types of mycotoxins. Current analytical methods, such as different types of chromatography and enzyme-linked immunosorbent assay, are time consuming or require complex sample preparation, data collection, and analysis. A method possessing better analytical performance and providing reliable results within a short time is a "holy grail" dream in healthcare applications, [4] but characteristic of plasmon-coupled Raman scattering. A spectroscopic tool is considered a cutting-edge method for biosensing applications, especially in the food industry, where product quality monitoring is of prior interest.Surface-enhanced Raman spectroscopy (SERS) is closely associated with nanoengineering of nanorough plasmonic substrates, serving as an origin for photon scattering's electromagnetic enhancement. [5] A prominent nanoroughness and a high aspect ratio at the atomic scale are the surface properties for customizing optically induced regions with strong electric field confinement, known as "hot spots". Surface patterns composed of vertically standing, inclined pillar-like structures with rough sidewalls and developed tips, willing to provide excellent plasmonic media, are considered as substrates to build up high-performing SERS-active detectors. The superior analytical sensitivity, temporal stability, chemical inertness and reusability, of such templates are crucial for SERS sensing and directly linked to fabrication strategies. Recently, the large-scale production methodologies listing lithography related, [6,7] oblique angle deposition techniques, [8,9] and surface etching approaches [10,11] have proved SERS usability of metallic, metal coated and nanometer-thick oxide-layer protected pillar-like substrates. Although, Mycotoxins are widespread chemical entities in the agriculture and food industries that can induce cancer growth and immune deficiency, posing a serious health threat for humankind. These hazardous compounds are produced naturally by various molds (fungi) that contaminate different food products and can be detected in cereals, nuts, spices, and other food products. However, their detection, especially at minimally harmful concentrations, remains a serious analytical challenge. This research shows that highperforming plasmonic substr...

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“…To overcome this limitation, surface-enhanced Raman spectroscopy (SERS)based detection of NIR active nanoprobes has been applied as a multiplex imaging tool, given the narrow bandwidth (< 2 nm) of Raman signals [8][9][10]. SERS has been demonstrated as a powerful tool for biological and chemical analyses and imaging, owing to its high sensitivity, multiplexing ability, and selectivity [11][12][13][14][15][16][17][18][19].…”

Section: Backgroudmentioning

confidence: 99%

Highly Sensitive Near-Infrared SERS Nanoprobes for in Vivo Imaging Using Gold-Assembled Silica Nanoparticles with Controllable Nanogaps

Bock

Choi

Kim

et al. 2021

Preprint

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Backgroud: Surface-enhanced Raman scattering (SERS) imaging is widely exploited, given its advantages such as multiplex capacity, non-photobleaching property, and high sensitivity. Near-infrared (NIR) radiation is suitable for in vivo studies because it exhibits good tissue penetration capability. Results In this study, gold (Au)-assembled silica (SiO2) nanoparticles (SiO2@Au@Au NPs) as NIR SERS nanoprobes are synthesized by a seed-mediated growth method. SiO2@Au@Au NPs with six different sizes of Au NPs are prepared by controlling the concentration of the Au precursor in the growth step. Therefore, the surface plasmonic band of the nanogaps between Au NPs on the SiO2 surface could be controlled from 4.16 to 0.98 nm, thus generating SERS hotspots. SiO2@Au@Au NPs with a 0.98-nm gap shows high SERS signals after being subjected to an excitation wavelength of 785 nm (enhancement factor ~3.8 × 106). SiO2@Au@Au nanoprobes shows detectable in vivo SERS signals at a concentration of 16 µg/mL in a 7-mm-thick animal tissue specimen. SiO2@Au@Au NPs with 14 different Raman label compounds shows distinguishable SERS signals upon being subcutaneously injected into nude mice. Conclusion Through this study, it is highlighted that their potential for use in in vivo applications as multiplex nanoprobes.

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Highly Reproducible Surface-Enhanced Raman Scattering Detection of Alternariol Using Silver-Embedded Silica Nanoparticles

Cited by 18 publications

References 23 publications

Applications of surface‐enhanced Raman spectroscopy in environmental detection

Applications of surface‐enhanced Raman spectroscopy in environmental detection

Label‐Free Mycotoxin Raman Identification by High‐Performing Plasmonic Vertical Carbon Nanostructures

Highly Sensitive Near-Infrared SERS Nanoprobes for in Vivo Imaging Using Gold-Assembled Silica Nanoparticles with Controllable Nanogaps

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