Highly scalable and standardized organ-on-chip platform with TEER for biological barrier modeling

Nguyen, Hoang-Tuan; Rissanen, Siiri-Liisa; Peltokangas, Mimosa; Laakkonen, Tino; Kettunen, Jere; Barthod, Lara; Sivakumar, Ragul; Palojärvi, Anniina; Junttila, Pauliina; Talvitie, Jussi; Bassis, Michele; Nickels, Sarah L.; Kalvala, Sara; Ilina, Polina; Tammela, Päivi; Lehtonen, Sarka; Schwamborn, Jens C.; Mosser, Sebastien; Singh, Prateek

doi:10.1080/21688370.2024.2315702

Cited by 3 publications

(1 citation statement)

References 62 publications

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“…125,126 In these designs, the upper channel was modified into open well, linking one well each for the inlet and outlet of the lower channel through a membrane positioned on the opened upper layer, making up a total of 3 wells per chip unit. 127 Additionally, hydrogel-based tissue barrier chips have been developed with models incorporating 2 wells each for inlet and outlet of the hydrogel channel and the medium supplying channel, resulting in a 4-well model in 384 well plate format. 94,124 There are also versions with two side medium channels, constituting a 6-well model 51,128 or 9-well model.…”

Section: Challenges and Future Directionmentioning

confidence: 99%

Reconstitution of human tissue barrier function for precision and personalized medicine

Kim,

Yoon,

Lee

et al. 2024

Lab Chip

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Section: Challenges and Future Directionmentioning

confidence: 99%

Reconstitution of human tissue barrier function for precision and personalized medicine

Kim,

Yoon,

Lee

et al. 2024

Lab Chip

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Recreating chronic respiratory infectionsin vitrousing physiologically relevant models

Grassi,

Crabbé

2024

Eur Respir Rev

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Despite the need for effective treatments against chronic respiratory infections (often caused by pathogenic biofilms), only a few new antimicrobials have been introduced to the market in recent decades. Although different factors impede the successful advancement of antimicrobial candidates from the bench to the clinic, a major driver is the use of poorly predictive model systems in preclinical research. To bridge this translational gap, significant efforts have been made to develop physiologically relevant models capable of recapitulating the key aspects of the airway microenvironment that are known to influence infection dynamics and antimicrobial activityin vivo. In this review, we provide an overview of state-of-the-art cell culture platforms andex vivomodels that have been used to model chronic (biofilm-associated) airway infections, including air–liquid interfaces, three-dimensional cultures obtained with rotating-wall vessel bioreactors, lung-on-a-chips andex vivopig lungs. Our focus is on highlighting the advantages of these infection models over standard (abiotic) biofilm methods by describing studies that have benefited from these platforms to investigate chronic bacterial infections and explore novel antibiofilm strategies. Furthermore, we discuss the challenges that still need to be overcome to ensure the widespread application ofin vivo-like infection models in antimicrobial drug development, suggesting possible directions for future research. Bearing in mind that no single model is able to faithfully capture the full complexity of the (infected) airways, we emphasise the importance of informed model selection in order to generate clinically relevant experimental data.

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Hybrid-integrated devices for mimicking malignant brain tumors (“tumor-on-a-chip”) for in vitro development of targeted drug delivery and personalized therapy approaches

Zimina,

Sitkov,

Gareev

et al. 2024

Front. Med.

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Acute and requiring attention problem of oncotheranostics is a necessity for the urgent development of operative and precise diagnostics methods, followed by efficient therapy, to significantly reduce disability and mortality of citizens. A perspective way to achieve efficient personalized treatment is to use methods for operative evaluation of the individual drug load, properties of specific tumors and the effectiveness of selected therapy, and other actual features of pathology. Among the vast diversity of tumor types—brain tumors are the most invasive and malignant in humans with poor survival after diagnosis. Among brain tumors glioblastoma shows exceptionally high mortality. More studies are urgently needed to understand the risk factors and improve therapy approaches. One of the actively developing approaches is the tumor-on-a-chip (ToC) concept. This review examines the achievements of recent years in the field of ToC system developments. The basics of microfluidic chips technologies are considered in the context of their applications in solving oncological problems. Then the basic principles of tumors cultivation are considered to evaluate the main challengers in implementation of microfluidic devices, for growing cell cultures and possibilities of their treatment and observation. The main achievements in the culture types diversity approaches and their advantages are being analyzed. The modeling of angiogenesis and blood-brain barrier (BBB) on a chip, being a principally important elements of the life system, were considered in detail. The most interesting examples and achievements in the field of tumor-on-a-chip developments have been presented.

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Highly scalable and standardized organ-on-chip platform with TEER for biological barrier modeling

Cited by 3 publications

References 62 publications

Reconstitution of human tissue barrier function for precision and personalized medicine

Reconstitution of human tissue barrier function for precision and personalized medicine

Recreating chronic respiratory infectionsin vitrousing physiologically relevant models

Hybrid-integrated devices for mimicking malignant brain tumors (“tumor-on-a-chip”) for in vitro development of targeted drug delivery and personalized therapy approaches

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