Highly selective and sensitive nanoprobes for Hg(II) ions based on photoluminescent gold nanoclusters

Zhang, Yan; Yan, Meifen; Jiang, Jingjing; Gao, Pengfei; Zhang, Guomei; Choi, Martin M. F.; Dong, Chuan; Shuang, Shaomin

doi:10.1016/j.snb.2016.05.108

Cited by 40 publications

(9 citation statements)

References 34 publications

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“…12−18 Especially, DNA-based fluorescent assays toward Hg 2+ detection have been widely reported based on the specific binding of thymine (T) toward Hg 2+ and the formation of T-Hg 2+ -T structure. 13,14,19−23 Sensors based on Hg 2+ -induced fluorescence quenching were developed for the determination of Hg 2+ by employing semiconductor quantum dots (QDs), 24 gold nanoclusters, 25,26 and carbon nanomaterials. 27−29 Compared with the T-Hg 2+ -T model, these assays were much simpler and lower in cost.…”

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confidence: 99%

“…Recently, various fluorescent assays have been developed to detect Hg 2+ due to unique advantages such as short response time, easy operation, and low required sample volume. − Especially, DNA-based fluorescent assays toward Hg 2+ detection have been widely reported based on the specific binding of thymine (T) toward Hg 2+ and the formation of T-Hg 2+ -T structure. ,,− Sensors based on Hg 2+ -induced fluorescence quenching were developed for the determination of Hg 2+ by employing semiconductor quantum dots (QDs), gold nanoclusters, , and carbon nanomaterials. − Compared with the T-Hg 2+ -T model, these assays were much simpler and lower in cost. Zang et al demonstrated preparation of β-lactoglobulin-stabilized gold nanoclusters for the measurement of Hg 2+ with high sensitivity in beverages, urine, and serum .…”

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confidence: 99%

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Black Phosphorus Quantum Dots as the Ratiometric Fluorescence Probe for Trace Mercury Ion Detection Based on Inner Filter Effect

et al. 2017

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In this work, a novel ratiometric fluorescence sensor has been constructed for the selective and sensitive detection of Hg, which is based on the inner filter effect (IFE) of tetraphenylporphyrin tetrasulfonic acid (TPPS) toward black phosphorus quantum dots (BP QDs). Highly fluorescent BP QDs were successfully synthesized from bulk BP by sonication-assisted solvothermal method via a top-down route. In the presence of Hg, the IFE originating from spectral overlap between the excitation of BP QDs and the absorption of TPPS is inhibited and the fluorescence of BP QDs is restored. At the same time, the red fluorescence of TPPS is quenched due to its coordination with Mn. These phenomena result from the rapid coordination between Mn and TPPS in the presence of Hg, which leads to the dramatic decrease of the absorption of TPPS. On the basis of these findings, we design a ratiometric fluorescence sensor for the detection of Hg. The as-constructed sensor reveals a good linear response to Hg ranging from 1 to 60 nM with a detection limit of 0.39 nM. Furthermore, the sensing assay is applicable to detecting Hg in real samples.

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Black Phosphorus Quantum Dots as the Ratiometric Fluorescence Probe for Trace Mercury Ion Detection Based on Inner Filter Effect

et al. 2017

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“…Subsequently, S 2− can react with AuNPs@BSA@Au 35 NCs to form Au 2 S rapidly only in the presence of H 2 S and further quench the fluorescence of AuNPs@BSA@Au 35 NCs through the ligand−metal−metal charge transfer (LMMCT). 35 In addition, the zeta potential of AuNPs@BSA@Au 35 NCs decreased from −6.96 to −36.9 mV with the addition of H 2 S (Figure S16), indicating that H 2 S was bound to the surface of AuNPs@BSA@Au 35 NCs via the interaction of Au−S bonds. 36 Contrast with those in Figure 1H, the XPS spectra changed obviously in the presence of H 2 S (Figure S17), indicating the interaction between H 2 S and AuNPs@BSA@Au 35 NCs.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…However, the higher steric hindrances of Cys and Hcy could not reach the surface of AuNPs@BSA@Au 35 NCs. Subsequently, S 2– can react with AuNPs@BSA@Au 35 NCs to form Au 2 S rapidly only in the presence of H 2 S and further quench the fluorescence of AuNPs@BSA@Au 35 NCs through the ligand–metal–metal charge transfer (LMMCT) . In addition, the zeta potential of AuNPs@BSA@Au 35 NCs decreased from −6.96 to −36.9 mV with the addition of H 2 S (Figure S16), indicating that H 2 S was bound to the surface of AuNPs@BSA@Au 35 NCs via the interaction of Au–S bonds .…”

Section: Resultsmentioning

confidence: 99%

Engineering Plasmon-Enhanced Fluorescent Gold Nanoclusters Using Bovine Serum Albumin as a Novel Separation Layer for Improved Selectivity

Chen

Tian

2022

Anal. Chem.

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The combination of gold nanoclusters (AuNCs) with surface plasmonic metal nanomaterials is an effective and direct method to improve the photoluminescence efficiency of AuNCs. However, the plasmon-enhanced AuNC luminescence strategies usually utilize silica as the separation layer, which requires further functionalization because the silica layer has no functional groups for in situ bonding of AuNCs. Therefore, it appears as a crucial need to develop an appropriate separation layer for the preparation of plasmon-enhanced AuNC luminescent nanomaterials. In this work, employing bovine serum albumin (BSA) as a novel separation layer, we prepared gold nanoparticles (AuNPs)@BSA@Au35NCs by a controllable and in situ synthesis method. BSA can form a BSA layer on the surface of AuNPs through Au–S bonds. Meanwhile, BSA can reduce AuCl4 – ions to generate Au35NCs. In comparison with pure BSA-AuNCs, the quantum yield of the AuNPs@BSA@Au35NCs was increased by nearly 7 times as a result of plasmonic coupling, and the time of in situ synthesis of Au35NCs was shortened by 8 h. More importantly, the preparation of the BSA layer was simple and time-saving without functionalization, in contrast to the previously reported silica layer. Moreover, the simulation calculation of different dimensions determined the optimal binding sites between Au35NCs and BSA, confirming that BSA can be an effective spatial spacer. Finally, it was found that the BSA layer between AuNPs and AuNCs can improve the specificity of AuNCs toward H2S, which is extremely difficult for pure BSA@AuNCs.

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“…The performance of the developed DTT/C-AuNCs ratiometric fluorescence sensor for the detection of Hg 2+ was compared with other different AuNCs-based fluorescence detection approaches, as listed in Table S1. Some researchers have reported the use of different proteins or enzymes as the stabilizer for the synthesis of AuNCs for improving the detection effect of Hg 2+ [40][41][42][43], but these methods cannot show a color change as the concentration of Hg 2+ varies. In our work, we constructed a ratiometric fluorescence sensor, employing AuNCs as a response signal to discern Hg 2+ , which could visually detect Hg 2+ according to an obvious color change from orange-red to blue.…”

Section: Methods Performance Comparisonmentioning

confidence: 99%

Ratiometric fluorescence sensor based on dithiothreitol modified carbon dots-gold nanoclusters for the sensitive detection of mercury ions in water samples

Wang

et al. 2018

Sensors and Actuators B: Chemical

115

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Ratiometric fluorescence sensors can provide more accurate analysis of target objects because of their self-calibration function. Traditional methods often use steps of chemical coupling with two different fluorescent materials as the dual emission source, which make the construction process complicated and hard to control. Here, we report a convenient and effective way to construct a ratiometric fluorescence sensor based on dual-emission carbon dots-gold nanoclusters (C-AuNCs) functionalized with dithiothreitol (DTT) for the sensitive detection of mercury ions (Hg 2+ ) in water samples. As a type of novel nanoparticle, C-AuNCs are synthesized via microwaving a mixture of gold seeds solution and carbon precursor. In the presence of Hg 2+ , the free thiol group of DTT would attract them around the surface of C-AuNCs, and owing to the strong 5d 10 -5d 10 metallophilic interactions between Hg 2+ and Au + , the fluorescence emission at 598 nm is quenched while the emission at 466 nm remains at a constant intensity. Thus, an obvious color change from orange-red to blue under ultraviolet irradiation can be observed by the naked eye. Moreover, the as-prepared fluorescence sensor has high sensitivity with a detection limit of 8.7 nM, and successfully applies to detect Hg 2+ in real water samples with satisfactory recoveries at three spiking levels ranging from 95.9 − 103.5%. The good results imply that the developed DTT/C-AuNCs sensor is conducive to trace Hg 2+ determination and possesses the great application potential for water-quality monitoring.

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Highly selective and sensitive nanoprobes for Hg(II) ions based on photoluminescent gold nanoclusters

Cited by 40 publications

References 34 publications

Black Phosphorus Quantum Dots as the Ratiometric Fluorescence Probe for Trace Mercury Ion Detection Based on Inner Filter Effect

Black Phosphorus Quantum Dots as the Ratiometric Fluorescence Probe for Trace Mercury Ion Detection Based on Inner Filter Effect

Engineering Plasmon-Enhanced Fluorescent Gold Nanoclusters Using Bovine Serum Albumin as a Novel Separation Layer for Improved Selectivity

Ratiometric fluorescence sensor based on dithiothreitol modified carbon dots-gold nanoclusters for the sensitive detection of mercury ions in water samples

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