Highly selective and sensitive ‘on–off’ fluorescent chemosensor for Fe³⁺ ions crafted by benzofuran moiety in both experimental and theoretical methods

Abstract

A benzofuran glycinamide-based chemosensor, 3-(2-([4-fluorobenzyl]amino)acetamido)benzofuran-2-carboxamide (BGA) was developed and synthesized for the selective and sensitive detection of Fe 3+ ions. The photophysical properties of the probe BGA were studied using UV-visible light absorption and fluorescence spectrophotometers. The chemosensor BGA showed a marked 'on-off' fluorescence response towards Fe 3+ ions in the presence of other metal ions in DMSO/H 2 O solution (9/1, v/v). The very low limits of detection (LOD) were calculated to be 10 nM and 43 nM using UV-visible light absorption and fluorescence spectrophotometers, respectively. Job's plot analysis revealed the formation of a BGA-Fe 3+ complex with a 1:1 binding stoichiometry ratio using UV-visible light spectroscopy.The sensing mechanism was also demonstrated using density functional theory calculation.

Rapid, Sensitive, and Selective "ON–OFF" Detection of Fe3+ Ions Using Novel Acetalophanes and Their Applications in Real Samples

“…To enhance the quality and quantity of this method, ongoing efforts have focused on re ning the design of recognition motifs for uorescent sensors. In this regard, a variety of structural designs of sensors has been developed to achieve the recognition of Fe 3+ ions through various recognition mechanisms [9][10][11][12][13][14][15][16][17][18][19][20]. To date, a variety of reaction-based uorescence probes have been developed to detect Fe 3+ [14][15][16][17][18][19][20].…”

Coumarin‐Oxazolyl‐Based Chemosensor for Selective Detection of Fe2+ Ions: Preparation, Spectral Characterization, Theoretical Studies and Cellular Bioimaging

“…Various Schiffbase derivatives and coumarin derivatives are widely used as suitable chemosensors due to their optoelectronic properties, hydrophobicity, chelation and variation in structural properties. [27] On the other hand, lot of sensors for Fe 3 + were reported in literature, [28,29] though the sensors for Fe 2 + were much less explored. Hence, we focused to find low cost, efficient sensors for Fe 2 + using coumarin oxazolyl type compounds.…”

Fast, Selective and Sensitive Fluorescence Detection of Levofloxacin, Fe3+ and Cu2+ Ions in 100% Aqueous Solution Via Their Reciprocal Recognition

“…It has turned out to be an applicable tool for on-site monitoring due to operational simplicity, high sensitivity, high selectivity, real-time imaging, lesser time consumption, cost-effectiveness, fast detection time and possibility for visual detection [6]. Recently, a large number of fluorescent chemosensors for Cu 2+ [7][8][9] or Fe 3+ ions [10][11][12][13][14] have been reported in which the mechanism of detection is generally based on either charge transfer or paramagnetic quenching processes. However, the simultaneous detection of two paramagnetic metal ions with different response remains still a great challenge.…”