Highly Selective Fluorescence Detection of Cu²⁺in Water by Chiral Dimeric Zn²⁺Complexes through Direct Displacement

Abstract

Fluorescent dinuclear chiral zinc complexes were synthesized in a "one-pot" method in which the lysine-based Schiff base ligand was generated in situ. This complex acts as a highly sensitive and selective fluorescent ON-OFF probe for Cu(2+) in water at physiological pH. Other metal ions such as Hg(2+), Cd(2+), and Pb(2+) gave little fluorescence change.

Bis-Benzimidazolyl Diamide Based Fluorescent Probe for Copper(II): Synthesis, Structural and Fluorescence Studies

“…Owing to its high detection sensitivity and operational simplicity fluorescent sensor of Cu 2+ is used to elucidate the role of metal ion in vivo as well as to monitor its concentration in metal-contaminated sources. In recent years, many fluorescent chemosensors have been reported which detect Cu 2+ in organic and aqueousorganic media in the range from 5 μM-20 μM [11,14,36,37]. The present system detects 12.5 μM of Cu 2+ in organic and organic-aqueous media.…”

“…A large numbers of new fluorescent probes that detect transition metal ions in solution have been reported [4][5][6][7][8][9][10][11][12][13][14][15]. A new area where organic molecules are utilized to act as sensors, switches, triggers and logic gates has developed rapidly.…”

2,4-Diamino-6-Hydroxypyrimidine Based Poly(azomethine-Urethane): Synthesis and Application as a Fluorescent Probe for Detection of Cu2+ in Aqueous Solution

“…As the third most abundant trace element in human body behind iron and zinc, copper plays an important role in many fundamental metabolic and physiological processes such as co-factor for electron transport, as a catalyst in some oxidation-reduction reactions, mitochondrial respiration, bone metabolism, wound healing, connective tissue formation, and the mobilization and uptake of iron [8][9][10][11][12]. On the other hand, high amount of this metal ion is harmful to biological systems and excess concentration of Cu 2+ can cause serious neurodegenerative diseases such as Wilson's disease, Alzheimer's disease, prion-induced diseases, Wilson disease and Parkinson's disease [13][14][15]. Due to importance of Cu 2+ , a method for selective, rapid and sensitive recognition of this transition metal ion in biological, water samples and aqueous solution is of great significance.…”

“…As known, simply structured azomethine group (−N=CH) or Schiff base and their derivatives are potentially capable of forming stable complexes with metal ions due to nitrogen atom of azomethine (−N=CH) double bound in Schiff base structure [16,17] and they have special coordination ability with transition metal ions [18]. Characterization of these prepared compounds were carried out by FT-IR, 1 H, 13 C-NMR and SEC techniques. P h o t o p h y s i c a l b e h a v i o r o f S c h i ff b a s e a n d i t s poly(azomethine-urethane) derivative was studied in different solvents such as DMF, MeOH or THF, and in presence of different metal ions focussing the attention on their emission properties using fluorescence spectroscopy.…”

Fluorescent probe for copper(II) ion based on a rhodamine spirolactame derivative, and its application to fluorescent imaging in living cells

“…Because of its operational simplicity, low cost, real time monitoring and high selectivity, fluorescent detection has become the promising strategy used for Cu 2+ detection. Even though considerable efforts have been undertaken to develop fluorescent probes for Cu 2+ , many reported fluorescent probes generally undergo fluorescence quenching upon binding with its inherent paramagnetic nature [4][5][6][7][8][9][10], which is not as sensitive as a fluorescence enhancement response. Recently there are still a few examples reported wherein enhancement in the fluorescence intensity has been observed upon complexation with Cu 2+ ions [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25].…”