Highly selective fluorimetric and colorimetric sensing of mercury(II) by exploiting the self-assembly-induced emission of 4-chlorothiophenol capped copper nanoclusters
“…Figure 4 c shows the changes in the absorbance spectra after the addition of Na + . Figure 4 ( a ) Schematic representation showing the mechanism of the selective determination of Na + using CuC based colorimetric probe (Image concept courtesy 38 ). ( b ) Colorimetric detection of Na + from different sources.…”
The homeostatic control of Sodium (Na+) ion in the human body assumes paramount relevance owing to its physiological importance. Any deviation from the normal level causes serious health problems like hypernatremia, hyponatremia, stroke, kidney problems etc. Therefore, quantification of Na+ levels in body fluids has significant diagnostic and prognostic importance. However, interfering ions like Potassium ion (K+) is the major hurdle in sodium detection. In this work, we synthesized the clusters of 3–9 nm-sized highly stable and pure Copper nanoparticles surface functionalised with curcumin, through chemical reduction method. Each cluster of particles is encapsulated in a curcumin layer which is clearly visible in TEM images. The results show that these curcumin functionalized Cu NPs (CuC) are highly selective to the colorimetric detection of Na+. The ions like K+, Mg2+ and Zn2+ did not interfere with the Na+ in this sensing technique. Low-cost paper-based sensor strips are fabricated and calibrated for the sensing of sodium in the physiological range and shade cards were developed as a calorimetric guide for estimation of Na+ which makes them ideal point of care diagnostic platform. We demonstrate that the proposed CuC paper strip can be used for detecting Na+ concentration within the whole physiological range in both blood serum and urine.
“…Figure 4 c shows the changes in the absorbance spectra after the addition of Na + . Figure 4 ( a ) Schematic representation showing the mechanism of the selective determination of Na + using CuC based colorimetric probe (Image concept courtesy 38 ). ( b ) Colorimetric detection of Na + from different sources.…”
The homeostatic control of Sodium (Na+) ion in the human body assumes paramount relevance owing to its physiological importance. Any deviation from the normal level causes serious health problems like hypernatremia, hyponatremia, stroke, kidney problems etc. Therefore, quantification of Na+ levels in body fluids has significant diagnostic and prognostic importance. However, interfering ions like Potassium ion (K+) is the major hurdle in sodium detection. In this work, we synthesized the clusters of 3–9 nm-sized highly stable and pure Copper nanoparticles surface functionalised with curcumin, through chemical reduction method. Each cluster of particles is encapsulated in a curcumin layer which is clearly visible in TEM images. The results show that these curcumin functionalized Cu NPs (CuC) are highly selective to the colorimetric detection of Na+. The ions like K+, Mg2+ and Zn2+ did not interfere with the Na+ in this sensing technique. Low-cost paper-based sensor strips are fabricated and calibrated for the sensing of sodium in the physiological range and shade cards were developed as a calorimetric guide for estimation of Na+ which makes them ideal point of care diagnostic platform. We demonstrate that the proposed CuC paper strip can be used for detecting Na+ concentration within the whole physiological range in both blood serum and urine.
“…[4][5][6][7][8] It has been well addressed that fluorogenic probes are effective tools for sensitive and selective detection of mercury (Hg 2+ ) ions. [9][10][11] Kuo and coworkers developed pyrene or rhodamine derivative-modified surfaces of electrospun nanofibrous chemosensors for colorimetric and fluorescent determination of copper (Cu 2+ ) ion, Hg 2+ ion, and pH. 12 Later they prepared new fluorescent electrospun nanofibres from multifunctional copolymers.…”
Section: Introductionmentioning
confidence: 99%
“…This is because mercury could cause serious health and safety problems to mankind and environment even at low concentrations as one of the most toxic elements 1–3 while pH plays a crucial role in many fields including human health care and biomedical analysis, environmental monitoring, chemical and biochemical reaction monitoring and control, and electrochemical sensing 4–8 . It has been well addressed that fluorogenic probes are effective tools for sensitive and selective detection of mercury (Hg 2+ ) ions 9–11 . Kuo and coworkers developed pyrene or rhodamine derivative‐modified surfaces of electrospun nanofibrous chemosensors for colorimetric and fluorescent determination of copper (Cu 2+ ) ion, Hg 2+ ion, and pH 12 .…”
Section: Introductionmentioning
confidence: 99%
“…measured at different times(1,3,5,7,9,11,13,15,17,19,21,23,25,27,29,31,33,35,37,39,41,43, 45, 47, 49 and 51 min) upon addition of Hg 2+ ion (20 μM) in DMSO/H 2 O (7:3, v/v) were measured and shown in Figure 5. Changes in the fluorescence intensity at 625 nm of CY (20 μM) with upon addition of 1 equivalent of Hg 2+ ion in DMSO/H 2 O (7:3, v/v) revealed that probe CY responded to Hg 2+ ion very rapidly and adding Hg 2+ ion to CY solution induced remarkable enhancement of the fluorescence intensity in 1 min.…”
A fluorescent probe derived from cyanine-rhodanine conjugate was developed for dual detection of mercury (Hg 2+ ) ion and pH. Addition of Hg 2+ ion to the weakly fluorescent probe solution in dimethyl sulphoxide/water (DMSO/H 2 O, 7:3, v/v) induced discernible colour change and fluorescence enhancement while other metal cations including
“…These methods supply effective and diverse approaches for the determination of Cu 2+ and PPi in a large variety of cases. For example, Wang et al have reported several fluorescent biosensors for the determination of heavy ions and PPi with a low detection limit and wide linear range [10][11][12][13]. However, some inevitable limitations, such as expensive instruments and sophisticated operating procedures remain.…”
Graphical abstract
In this report, portable, quantitative, and sequential monitoring of copper ions and pyrophosphate (PPi) with a single sensor based on a DNAzyme-Fe
3
O
4
system and glucometer readout was performed. Initially, streptavidin was functionalized on the surface of magnetic Fe
3
O
4
spheres through glutaraldehyde. Then, an invertase-modified DNA Cu substrate was connected to the magnetic Fe
3
O
4
spheres by a specific reaction between streptavidin and biotin. The sensing system was formed by a hybridization reaction between the Cu substrate and Cu enzyme. In the presence of Cu
2+
, Cu
2+
will recognize the Cu DNA substrate and form an “off-on” signal switch, thereby resulting in the separation of invertase from the Fe
3
O
4
nanospheres. PPi recognizes Cu
2+
to form a Cu
2+
-PPi complex, resulting in an “on-off” signal switch. Under optimized conditions, linear detection ranges for Cu
2+
and PPi of 0.01–5 and 0.5–10 μM, and detection limits for Cu
2+
and PPi of 10 nM and 500 nM, respectively, were obtained. Good selectivity was achieved for the analysis of Cu
2+
and PPi. Satisfactory results were achieved for this biosensor during the determination of Cu
2+
in real tap samples and PPi in human urine samples. This verified that the sensor is portable and low cost, and can be applied to the sequential monitoring of multiple analytes with a single point-of-care biosensor.
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