Highly Selective Rational Design of Peptide-Based Surface Plasmon Resonance Sensor for Direct Determination of 2,4,6-trinitrotoluene (TNT) Explosive

Wang, Jin; Muto, Masaki; Yatabe, Rui; Tahara, Yusuke; Onodera, Takeshi; Tanaka, Masayoshi; Okochi, Mina; Toko, Kiyoshi

doi:10.1016/j.snb.2018.02.075

Cited by 46 publications

(22 citation statements)

References 25 publications

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“…The TNT-binding peptide was determined to be TNTHCDR3 (ARGYSSFIYWFFDFC) according to our previous work [10,11,12]. A SPR sensor chip covered with a 50-nm gold layer was used for multistep functionalization (Figure 1).…”

Section: Methodsmentioning

confidence: 99%

“…The synthesis and screening of 2,4,6-trinitrotoluene (TNT)-binding peptides for the direct detection of TNT explosives using SPR sensors has been previously investigated [10,11,12]. However, obtaining high sensitivity and selectivity has been hampered by SPR sensors without signal amplification.…”

Section: Introductionmentioning

confidence: 99%

“…SWCNTs with diameters of a few nanometers keep the interaction between the bioreceptor and the analytes in the effective range where the changes in the refractive index within the electric field could be measured sensitively. In this study, TNTHCDR3 (15-amino acid sequence: ARGYSSFIYWFFDFC), demonstrated to be a TNT recognition peptide [10,11,12], was enriched in three kinds of aromatic amino acids (Y, tyrosine; W, tryptophan; and F, phenylalanine), which bind to the SWCNTs surface through noncovalent bonding via π–π interactions. The results reveal that the proposed method offers enhanced sensitivity, selectivity, and long-term stability in the detection of TNT explosives.…”

Section: Introductionmentioning

confidence: 99%

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An SPR Sensor Chip Based on Peptide-Modified Single-Walled Carbon Nanotubes with Enhanced Sensitivity and Selectivity in the Detection of 2,4,6-Trinitrotoluene Explosives

Wang

Onodera

et al. 2018

Sensors

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In this study, we developed a surface plasmon resonance (SPR) sensor chip based on 2,4,6-trinitrotoluene (TNT) recognition peptide-modified single-walled carbon nanotubes (SWCNTs). The carboxylic acid-functionalized SWCNTs were immobilized on a 3-aminopropyltriethoxysilane (APTES)-modified SPR Au chip surface. Through π-stacking between the aromatic amino acids and SWCNTs, the TNT recognition peptide TNTHCDR3 was immobilized onto the surface of the SWCNTs. The peptide–SWCNTs-modified sensor surface was confirmed and evaluated by atomic force microscope (AFM) observation. The peptide–SWCNTs hybrid SPR sensor chip exhibited enhanced sensitivity with a limit of detection (LOD) of 772 ppb and highly selective detection compared with commercialized carboxymethylated dextran matrix sensor chips.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An SPR Sensor Chip Based on Peptide-Modified Single-Walled Carbon Nanotubes with Enhanced Sensitivity and Selectivity in the Detection of 2,4,6-Trinitrotoluene Explosives

Wang

Onodera

et al. 2018

Sensors

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“…While the widespread application of HNIW is limited severely owning to its high production costs and high sensitivity. 2,4,6-Trinitrotoluene (TNT) is an explosive with good thermal stability and high insensitivity [39][40]. However, the poor density, low oxygen balance, and modest detonation velocity of TNT also restrict high performance applications.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization and the Thermodynamic Properties of HNIW ⋅ TNT Cocrystal

Jia

Zhang

Kou

et al. 2019

Propellants Explo Pyrotec

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The cocrystal of 2,4,6,8,10,12‐hexanitrohexaazaisowurtzitane (HNIW) with 2,4,6‐trinitrotoluene (TNT) (in a 1 : 1 mole ratio) was prepared by a solvent /non‐solvent (acetonitrile/distilled water) method, and systematically characterized by several methods. The thermal decomposition kinetics of HNIW ⋅ TNT cocrystal were investigated using dynamic Differential Scanning Calorimetry (DSC), and the apparent activation energy (Ea ) was calculated by Kissinger‐Akahira‐Sunose (KAS), Flynn‐Wall‐Ozawa (FWO) and Starink methods. The standard molar enthalpy of formation (ΔnormalfHmθ ) of HNIW ⋅ TNT cocrystal was acquired by a DC08‐1 Calvet microcalorimeter with the help of a rational thermochemical cycle and was 324.45±0.15 kJ mol−1. A continuous Cp mode of Micro‐DSC III was used to determine the specific heat capacity (Cp,m) of HNIW ⋅ TNT cocrystal from T=(283.15–333.15) K, and the Cp,m was 673.62 J mol−1 K−1 at 298.15 K.

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“…The TNT recognition peptide was synthesized in accordance with our previous work. (18,19) The mechanism for TNT explosive detection is based on the change in potential, which is mainly caused by the charge transfer between the positively charged group in TNT molecules and the negatively charged TNTHCDR3 peptide during the binding interaction. The sensitivity, selectivity, and stability of the peptide-based potentiometric device were investigated to evaluate its performance.…”

Section: Introductionmentioning

confidence: 99%

Peptide-modified Microelectrode-based Potentiometric Device for 2,4,6-trinitrotoluene Molecule Detection

Wang

Yatabe²,

Onodera³

et al. 2019

Sensors and Materials

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A 2,4,6-trinitrotoluene (TNT) molecule recognition peptide-modified potentiometric device was developed in a multiparallel way using microelectrodes. The change in potential caused by the explosive target and recognition peptide was monitored in real-time sensorgrams through our laboratory-built analysis system. The peptide-modified microelectrode-based potentiometric device demonstrated the highly selective and sensitive sensing of the TNT molecule over other aromatic analogues.

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Highly Selective Rational Design of Peptide-Based Surface Plasmon Resonance Sensor for Direct Determination of 2,4,6-trinitrotoluene (TNT) Explosive

Cited by 46 publications

References 25 publications

An SPR Sensor Chip Based on Peptide-Modified Single-Walled Carbon Nanotubes with Enhanced Sensitivity and Selectivity in the Detection of 2,4,6-Trinitrotoluene Explosives

An SPR Sensor Chip Based on Peptide-Modified Single-Walled Carbon Nanotubes with Enhanced Sensitivity and Selectivity in the Detection of 2,4,6-Trinitrotoluene Explosives

Preparation, Characterization and the Thermodynamic Properties of HNIW ⋅ TNT Cocrystal

Peptide-modified Microelectrode-based Potentiometric Device for 2,4,6-trinitrotoluene Molecule Detection

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