Highly sensitive amperometric biosensor based on electrochemically-reduced graphene oxide-chitosan/hemoglobin nanocomposite for nitromethane determination

Wen, Yunping; Wen, Wei; Zhang, Xun; Wang, Shengfu

doi:10.1016/j.bios.2016.01.028

Cited by 65 publications

(23 citation statements)

References 43 publications

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“…Carbon-based materials, such as graphene and carbon nanotubes, have become a hot spot in many research fields [20,21]. Graphene is a two-dimensional material with a layer of sp 2 C atoms tightly packed into a honeycomb lattice.…”

Section: Introductionmentioning

confidence: 99%

Flexible Hydrogen Peroxide Sensors Based on Platinum Modified Free-Standing Reduced Graphene Oxide Paper

Song

Wei

et al. 2018

Applied Sciences

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Abstract:In this article, we report a facile method to fabricate free-standing reduced graphene oxide paper (rGOP) by vacuum filtration. Pt nanoparticles were electrodeposited on reduced graphene oxide paper to construct a sensitive and flexible hydrogen peroxide (H 2 O 2 ) sensor. The properties of Pt/rGOP were characterized by scanning electron microscopy, energy dispersive X-ray, X-ray photoelectron spectroscopy and Raman spectroscopy. The electrochemical characterizations of the resulting sensor were carried out by cyclic voltammetry, chronoamperometry and electrochemical impedance spectroscopy. The Pt/rGOP hybrid electrode had an excellent electrochemical property, with superb electrocatalytic activity, a large electrochemical active surface area, flexibility and high stability. The linear ranges of the as-prepared sensor for H 2 O 2 detection were divided into two linear sections: 0.2 µmol/L to 2.0 mmol/L and 2.0 to 8.5 mmol/L, with a detection limit of 100 nmol/L (S/N = 3) and a response time of less than 5 s. The proposed sensor has great potential to become a reliable and flexible tool in biosensor and point-of-care medical devices.

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Section: Introductionmentioning

confidence: 99%

Flexible Hydrogen Peroxide Sensors Based on Platinum Modified Free-Standing Reduced Graphene Oxide Paper

Song

Wei

et al. 2018

Applied Sciences

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“…The sp 2 ‐hybridized carbon atoms provide the conductivity to these molecules . Graphene is a two‐dimensional (2‐D) and mono‐ or few‐layered form of graphite, which is very attractive because of superior features like biocompatibility, large surface area, high thermal conductivity, and excellent mechanical flexibility . In addition, graphene exhibits marvelous electrical properties including high electron mobility and electrical conductivity.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, graphene exhibits marvelous electrical properties including high electron mobility and electrical conductivity. However, easy aggregation and poor dispersion in aqueous media due to the native hydrophobicity of graphene restrict its processing . These factors are the disadvantages for generating a homogenous conductive system in hydrogel network.…”

Section: Introductionmentioning

confidence: 99%

Production of reduced graphene oxide‐based electrically conductive hydrogel by using modified chitosan

Ulutürk

Alemdar

2019

J of Applied Polymer Sci

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Herein, a new approach was applied to produce reduced graphene oxide (RGO)‐based conductive hydrogel by using modified chitosan (CTS) as a primary constituent. A variety amounts of RGO (from 0 to 15%) were incorporated into the polymeric network generated by photopolymerization of CTS‐graft‐glycidyl methacrylate (CTS‐g‐GMA) and poly(ethylene glycol)diacrylate (PEGDA). The structures of hydrogels were confirmed by FT‐IR, XRD, and SEM analyses. Water uptake capacity of hydrogels determined gravimetrically. L929 fibroblast cells were used for cytotoxicity test. According to conductivity measurements carried out by four‐point probe technique, the highest conductivity (1.716 × 10−3 S/cm) was obtained when 10% RGO was encapsulated into the polymeric structure. From the results, it could be envisaged that electroconductive hydrogel (ECH) fabricated in this study could have a potential usage for biosensor applications in the future projects. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48008.

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“…Wen et al proposed that GO‐CHI complex can be bound onto the surface of a glass electrode by a simple drying procedure, then GO is electrochemically reduced and further can complex a CHI‐hemoglobin solution. This gives a sensor to measure nitromethane . Zhou et al reported CHI embedded in a polyphenolic reduced GO (in autoclave).…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility of composites based on chitosan, apatite, and graphene oxide for tissue applications

Panella

Fioravanti

et al. 2018

J Biomedical Materials Res

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Novel two-dimensional films and three-dimensional (3D) scaffolds based on chitosan (CHI), apatite (Ap), and graphene oxide (GO) were developed by an in situ synthesis in which self-assembly process was conducted to direct partial reduction of GO by CHI in acidic medium. Physical-chemical characterization was carried out by optical microscopy, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy, Raman spectroscopy, and X-ray photoelectron spectroscopy. In vitro biological studies using murine fibroblast (MC3T3) and human neuroblastoma (SH-SY5Y) cell lines were also performed. Cell growth and adherence on composites was also checked using SEM. Live and death staining by confocal microscope and 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium of the samples were investigated. The results confirmed the incorporation of both Ap and GO sheets, into CHI polymeric matrix. Furthermore, it was confirmed a physical integration between inorganic Ap and organic CHI and strong chemical interaction between CHI and GO in the obtained composites. SH-SY5Y cell line showed preferential adherence on CHI/GO films surface while MC3T3 cell line displayed a good compatibility for all 3D scaffolds. This study confirms the biocompatibility of materials based on CHI, Ap, and GO for future tissues applications. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1585-1594, 2018.

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Highly sensitive amperometric biosensor based on electrochemically-reduced graphene oxide-chitosan/hemoglobin nanocomposite for nitromethane determination

Cited by 65 publications

References 43 publications

Flexible Hydrogen Peroxide Sensors Based on Platinum Modified Free-Standing Reduced Graphene Oxide Paper

Flexible Hydrogen Peroxide Sensors Based on Platinum Modified Free-Standing Reduced Graphene Oxide Paper

Production of reduced graphene oxide‐based electrically conductive hydrogel by using modified chitosan

Biocompatibility of composites based on chitosan, apatite, and graphene oxide for tissue applications

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