Highly Sensitive and Direct Detection of DNA Fragments Using a Laser-Induced Capillary Vibration Effect

Odake, Tamao; Tsunoda, Kin-ichi; Kitamori, Takehiko; Sawada, Tsuguo

doi:10.2116/analsci.17.95

Cited by 5 publications

(1 citation statement)

References 21 publications

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“…All of these methods rely on fluorescent detection of DNA, using either labeled DNA or intercalating dyes. A recent report by Odake et al (79) showed detection of DNA using a laserinduced capillary vibration effect with sensitivity equivalent to traditional fluorescent detection. This method has not yet been applied to microchip DNA separations, but the possibility of using this detection method with DNA sequencing was reported.…”

Section: New Microchip-based Approaches With Potentialmentioning

confidence: 99%

Molecular Diagnostics on Electrophoretic Microchips

Landers

2003

Anal. Chem.

123

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Section: New Microchip-based Approaches With Potentialmentioning

confidence: 99%

Molecular Diagnostics on Electrophoretic Microchips

Landers

2003

Anal. Chem.

123

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Thermal effects of phase transformations: A review

Umantsev

2007

Physica D: Nonlinear Phenomena

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All the stages of phase transformations in materials, nucleation, growth, and coarsening, are subject to thermal effects that stem from the redistribution of energy in the system, like release of latent heat, and heat conduction. The thermal effects change the rate and outcome of the transformation and may result in the appearance of unusual states or phases, in particular in nanosystems. This review will cover the attempts of researchers to build a comprehensive theory of thermal effects in different phase transformations. Although the dynamical Ginzburg-Landau (continuum) approach will be used for the analysis of the effects, they are robust and conceivably independent of the theoretical method employed. On general physical grounds a possibility of an oscillatory regime in nucleation is considered and evolution equations for the interfacial motion are derived. The equations show that there are two distinctly different sets of thermal effects of interface motion: one set originates from the existence of the Gibbs-Duhem thermodynamic force on the interface, which has opposite directions compared to the velocity of the interface in the cases of continuous and discontinuous transitions, resulting in a heat trapping effect for the latter and a drag effect for the former. The other set of thermal effects stems from the existence of the surface internal energy and the necessity to carry it over together with the moving interface. As a result, temperature double layers accompany moving domain boundaries after a continuous transition or the surface creation and dissipation effect appear after a discontinuous one. An unusual, novel phase that may appear in isolated nanosystems (adiabatic nanophase) is described. Several experiments are suggested for the verification of the thermal effects in different material systems.

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The photoelastic effect evaluation by means of photothermal deflection technique

Paoloni

Bertolotti

2003

Review of Scientific Instruments

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The collinear configuration of the photothermal deflection technique is applied here to evaluate the influence of the photoelastic effect in the refractive index variation. The measurement procedure is based on analysis of the phase signal linear decay as a function of the distance between the beams. By comparing lateral scans obtained for different polarization states of the probe beam, it is possible to derive the relative influence of the two mechanisms (opto-thermal and photoelastic) responsible for deflecting the probe. Experimental results obtained for a glass sample which validate the proposed method are also shown.

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Highly Sensitive and Direct Detection of DNA Fragments Using a Laser-Induced Capillary Vibration Effect

Cited by 5 publications

References 21 publications

Molecular Diagnostics on Electrophoretic Microchips

Molecular Diagnostics on Electrophoretic Microchips

Thermal effects of phase transformations: A review

The photoelastic effect evaluation by means of photothermal deflection technique

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