Highly Sensitive Carbon Based Sensing Utilizing Titanium Dioxide Nanoparticles and Multiwalled Carbon Nanotubes for Determination of Ticagrelor: Pharmacokinetics Application

Abstract

Sensitive, accurate and precise square-wave voltammetric method was developed and validated for determination of a new antiplatelet drug ticagrelor in drug substance using multi-walled carbon nanotubes titanium dioxide nanoparticles modified carbon paste electrode (MWCNTs/TiNPs/CPE). The electrochemical behavior of ticagrelor showed irreversible adsorption-diffusion controlled process at potential of 0.97 V in Britton Robinson buffer (pH 2.0). Various experimental conditions were investigated and optimized including different pH, buffers, electrode modifiers, scan rates and several surfactants. The diffusion coefficient was calculated using chronoamperometric technique. The peak current varied linearly over the concentration ranges from 1.00 × 10 −6 mol L −1 to 1.90 × 10 −4 mol L −1 with correlation coefficients of 0.9992. The detection and quantification limits were 2.81 × 10 −7 and 8.41 × 10 −7 mol L −1 , respectively. The method was successfully applied for the determination of ticagrelor in drug product and biological fluid. The pharmacokinetic parameters of drug in human plasma were estimated as: C max = 1.19 × 10 −6 mol L −1 , t max = 2 h, CL = 0.0024 Lh −1 and t 1/2 = 6.5 h which are favorably compared with those reported in literature.

Determination of ticagrelol in rat plasma and tablets by micellar electrokinetic chromatography coupled with large volume sample stacking: Application to a pharmacokinetic study

“…The elimination half-life (t 1/2 ) of TIC was from 4.83 to 4.94 h -1 . The time-concentration profile and pharmacokinetic parameters obtained by our method were consistent with those obtained from previously published studies [8,9,48]. This indicates that plasma pharmacokinetics of TIC did not differ between with and without The values between parentheses are the tabulated t and F values at p = 0.05 [47].…”

“…Techniques such as ultraviolet (UV) spectrophotometry [6,7], voltammetry [8,9], spectrofluorometry [10], highperformance liquid chromatography (HPLC) [7,[11][12][13][14][15][16], HPLC-mass spectrometry (HPLC-MS) [17,18], and LCtandem MS (LC-MS-MS) [19][20][21][22] have been reported for the determination of TIC. Although these methods are promising and could easily obtain satisfactory repeatability and high sensitivity, most of them have been associated with several shortcomings, such as expensive equipment and the large amount of organic solvents consumed.…”

Electrochemical Derivatization of Acetaminophen for Indirect Determination of Eflornithine Using β‐CD Modified Glassy Carbon Electrode

“…Where I C0 p is the C 0 peak current, [DFMO] is the concentration of DFMO, and R is the correlation coefficient. Statistical analysis [71,72] of the obtained data represented satisfied values of correlation coefficient (R 2 ) 0.9913 (Table S1). The calibration curve linearity is confirmed by these data and low scattering of the points near the calibration curve.…”

Sample pretreatment and HPLC determination of antiplatelet drug ticagrelor in blood plasma from patients with acute coronary syndromes

“…One square wave voltammetric method (Rizk et al, 2017) and two fluorimetric methods have been developed for the determination of TCG in biological samples. A fluorimetric method based on TCG natural fluorescence was used only for plasma analysis in rat (Elmansi et al, 2020), whereas fluorescence derivatization was applied to spiked human plasma (Önal & Kepekçi Tekkeli, 2020).…”