Highly Sensitive Detection of Organophosphorus Pesticides Using 5,10,15,20-Tetrakis(4-hydroxyphenyl)porphyrin

Murakami, Takaya; Iwamuro, Yoshiaki; Chinaka, Satoshi; Takayama, Nariaki; Komatsu, Teruyuki

doi:10.2116/analsci.31.1325

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…This pharmaceutical product is used for the treatment of methicillin resistant to staphylococcus aureus and bacterial skin infections [ 33 ]. Other phosphomonoester drugs derived from primary alcohols include benfotiamine (Milgamma/Neurostop®) ( 11 ) for vitamin B1 deficiency, chlorinated drugs dichlorvos (DDVP)* ( 12 ) and triclofos* ( 13 ) [ [34] , [35] ].…”

Section: Classification Of P (V)-containing Drugsmentioning

confidence: 99%

Development and Clinical Application of Phosphorus-Containing Drugs

Shi³

et al. 2020

Medicine in Drug Discovery

120

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Phosphorus-containing drugs belong to an important class of therapeutic agents and are widely applied in daily clinical practices. Structurally, the phosphorus-containing drugs can be classified into phosphotriesters, phosphonates, phosphinates, phosphine oxides, phosphoric amides, bisphosphonates, phosphoric anhydrides, and others; functionally, they are often designed as prodrugs with improved selectivity and bioavailability, reduced side effects and toxicity, or biomolecule analogues with endogenous materials and antagonistic endoenzyme supplements. This review summarized the phosphorus-containing drugs currently on the market as well as a few promising molecules at clinical studies, with particular emphasis on their structural features, biological mechanism, and indications.

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Section: Classification Of P (V)-containing Drugsmentioning

confidence: 99%

Development and Clinical Application of Phosphorus-Containing Drugs

Shi³

et al. 2020

Medicine in Drug Discovery

120

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“…Using nonlethal surrogates for system optimization is acceptable, since OPs are CWA model compounds. 9 Indeed, DMMP is used as a simulant during sarin training exercises. DMMP is similar to sarin in polarity, volatility, and chemistry ( Fig.…”

Section: Gc Materialsmentioning

confidence: 99%

Thermodynamic Studies on a Hydrogen Bonded Acidic 3,5-Bis(trifluoromethyl)phenol-functionalized Polymer as a Gas Chromatography Stationary Phase for Selectively Speciating Chemical Warfare Agents

et al. 2019

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We describe for the first time hydrogen bonded acid (HBA) polymer, poly{methyl[3-(2-hydroxyl, 4,6-bistrifluoromethyl)phenyl]propylsiloxane}, (DKAP), as stationary phase for gas chromatography (μGC) of organophosphate (OP), chemical warfare agent (CWA) surrogates, dimethylmethylphosphonate (DMMP), diisopropylmethylphosphonate (DIMP), diethylmethylphosphonate (DEMP), and trimethylphosphate (TMP), with high selectivity. Absorption of OPs to DKAP was one-to-several orders of magnitude higher relative to commercial polar, mid-polar, and nonpolar stationary phases. We also present for the first-time thermodynamic studies on the absorption of OP vapors and quantitative binding energy data for interactions with various stationary phases. These data help to identify the best pair of hetero-polar columns for a two-dimensional GC system, employing a nonpolar stationary phase as GC1 and DKAP as the GC2 stationary phase, for selective and rapid field detection of CWAs.

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“…Chen et al 13 used a cobalt imidazolate (im) framework material, [Co(im)2]n, to detect trimethylamine, and achieved a low detection limit level of 2 ppm to TMA at 75 C. Many contributions that use porphyrins as gas-sensing materials have been reported in the field of sensor applications. Murakami et al 25 used 5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin to detect organophosphorus pesticides. In addition, Paolesse et al 26 have studied the response of porphyrin derivatives to toxic and volatile gases by means of spectroscopic techniques.…”

Section: Introductionmentioning

confidence: 99%

Detection of Trimethylamine Based on a Manganese Tetraphenylporphyrin Optical Waveguide Sensing Element

et al. 2018

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The sensitive detection of trimethylamine has been accomplished by using a homogeneous optical waveguide sensor system. Also the sensor can be easily fabricated by using tetraphenylporphyrin manganese (MnTPP) as sensitive materials to detect different volatile organic compounds (VOC). NMR (H-NMR), field-emission scanning electron microscopy (FESEM), and X-ray photoelectron spectroscopy (XPS), infrared (IR), and ultraviolet-visible (UV-vis) instrumental means were used to characterize its structure. Gas-sensing measurements indicated that the sensing element has shown good selectivity, high sensitivity and a low detection limit level of 0.1 ppm to trimethylamine (TMA) with the presence of interference gases at room temperature. For a range of trimethylamine concentrations from 0.1 to 1000 ppm, the sensor has shown a short response time. Also the response time and recovery time are 1.5 and 50 s, respectively. Simulation experiments (dichloromethane, chloroform and carbon tetrachloride were selected as interference gases) showed little interference with its gas sensing. That may provide an ideal candidate for detecting the freshness of fish and seafood.

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Highly Sensitive Detection of Organophosphorus Pesticides Using 5,10,15,20-Tetrakis(4-hydroxyphenyl)porphyrin

Cited by 6 publications

References 23 publications

Development and Clinical Application of Phosphorus-Containing Drugs

Development and Clinical Application of Phosphorus-Containing Drugs

Thermodynamic Studies on a Hydrogen Bonded Acidic 3,5-Bis(trifluoromethyl)phenol-functionalized Polymer as a Gas Chromatography Stationary Phase for Selectively Speciating Chemical Warfare Agents

Detection of Trimethylamine Based on a Manganese Tetraphenylporphyrin Optical Waveguide Sensing Element

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