Highly Sensitive Detection of Residual Chlorpromazine Hydrochloride with Solid Substrate Room Temperature Phosphorimetry

Liu, Jiaming; Lin, Liping; Wang, Xinxing; Lin, Xuan; Zhou, Ping; Lin, Shuo; Zheng, Zishan

doi:10.1007/s10895-012-1047-z

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…However, the extra amounts of this drug may have adverse effects on human health. The lethal dose of CPZ in the blood is 5-10 mg L À 1 [5]. Furthermore, due to the side effects and toxicities that the drug can have, the quality of it is important in terms of its active pharmaceutical ingredients [6].…”

Section: Introductionmentioning

confidence: 99%

“…Among the methods used for determination of CPZ such as spectrophotometry [7][8][9][10][11], electrochemiluminescence [12], fluorimetric [13], chromatography [14,15], phosphorimetry [5], the electrochemical methods, especially the voltammetric methods [16,17] have received increasing attention, due to their simplicity, rapidity, portability, cost-effectiveness, and sensitivity. Voltammetric sensors based on platinum disk [18], ruthenium [19], alkylthiol/phospholipid-modified gold electrode [20], graphene paste electrode [21] and multiwalled carbon nanotube-polyethyleneimine (MWCNT-PEI) composite modified GCE [17] have been reported.…”

Section: Introductionmentioning

confidence: 99%

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Determination of Chlorpromazine Hydrochloride with a Layered Double Hydroxide Modified Glassy Carbon Electrode as a Nanocatalyst

et al. 2020

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We report a simple and sensitive voltammetric sensor for the determination of chlorpromazine (CPZ) based on Ni−Al layered double hydroxide (NiAlLDH) modified glassy carbon electrode (GCE). NiAlLDH was simply electrodeposited on GCE surface in a very short time. The response linear range was 1×10−3–1×10−9 mol L−1, with a detection limit of 1×10−9 mol L−1. The NiAlLDH film showed well defined and well separate peaks for dopamine, ascorbic acid, uric acid and CPZ in the same solution. The proposed electrode was used to measure the active pharmaceutical ingredient of CPZ tablet as a real sample.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determination of Chlorpromazine Hydrochloride with a Layered Double Hydroxide Modified Glassy Carbon Electrode as a Nanocatalyst

et al. 2020

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“…New SSRTP for the chlorpromazine hydrochloride [22], quercetin [23], rhamnose [24], and carvedilol [25] detection promoted the progress in study of trace drugs analysis. However, SSRTP for the determination of trace Cyt C and forecast of human diseases has been rarely reported based on the enhancing effect of tween-80 on RTP of F-ol.…”

Section: Introductionmentioning

confidence: 99%

A Novel Solid Substrate Room Temperature Phosphorimetry for the Determination of Trace Cytochrome C and Forecast of Human Diseases

Zheng¹,

Cui

Liu

et al. 2012

ISRN Spectroscopy

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The reaction between fullerenol (F-ol) and cytochrome C (Cyt C) could be carried out to form a nonphosphorescence compound using tween-80 as photosensitizer which causes the sharp quenching of room temperature phosphorescence (RTP) of F-ol. Bearing this in mind, a novel solid substrate room temperature phosphorimetry (SSRTP) for the determination of trace Cyt C has been proposed in this study. Under the optimum conditions, the linear range of this method is 1.0 × 10 −16 -2.4 × 10 −14 g mL −1 , which is directly proportional to ΔI p of Cyt C-F-ol-tween-80 system, and the detection limit (DL) is 3.0 × 10 −17 g mL −1 . It has been applied to the determination of Cyt C in human serum and forecast of diseases, and the result matches with the enzyme-linked fluorescence immunoassay (ELISA). Meanwhile, the reaction mechanism of SSRTP for the determination of Cyt C and the enhancing effect of tween-80 on RTP of F-ol were also discussed.

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“…This is known to be a significant issue when studying the permeability of very lipophilic compounds. 174,175 The detailed data in Table 3.5 show the differences in the rate of absorbance, P app , and transport of 3.6 (PhIP) in the presence of BPs and their dimethyl esters. The absorption of 3.6 (PhIP) across a confluent Caco-2 cell monolayer was measured in the absence of any other additive and it exhibited a very high rate of transport from AP to BL, with total amount increasing from 0 to 180 min and reaching nearly 70% of 3.6 (PhIP) crossing to the BL after 180 min and with a P app of 1.74 x 10 -5 cm/s (Table 3.1 and Table 3.5).…”

Section: Resultsmentioning

confidence: 99%

Physical and chemical interactions between bile pigments and polyaromatic mutagens

Trieu¹

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A major cause of cancer in humans is exposure to mutagenic compounds. This raises the question of how humans can be protected from these environmental mutagens. Bile pigments (BPs) such as biliverdin, unconjugated bilirubin and protoporphyrin and their derivatives have recently been found to act as antioxidants and inhibit the mutagenic effects of several known environmental mutagens including 2-aminofluorene, benzo [α]pyrene, and 2-amino-1-methyl-6-phenylimido [4,5-b]pyridine. Despite these promising results, very little is known about the mechanisms by which this inhibition is achieved. Understanding these mechanisms would be useful for future drug development. Therefore, this PhD thesis aims to explore physical and chemical interactions between BPs and mutagens. Effects of BPs on the bioavailability and metabolism of mutagens were also examined in vitro using the colorectal adenocarcinoma (Caco-2 cell) monolayer model and the human liver S9 fraction.The physical interactions between mutagens and BPs were examined using three different methods:NMR, UV and effects of bioavailability. The results of the comparison of the NMR spectra of mutagens in the absence and presence of BPs showed very little changes in the chemical shifts of the protons and the changes that did occur were the result of acid/base interactions between the BPs and mutagens. The UV spectrum of each mutagen was measured in the presence and absence of varying concentrations of BPs, and there were no changes to the UV spectra of any of the compounds. Strong physical interactions or aggregation of compounds can also affect their absorption across cell monolayers and so the apparent permeability of mutagens across Caco-2 cell monolayers in the presence and absence of BPs were measured. The results indicated that BPs increased the permeability of the mutagens slightly and effected how much of the compounds remained in tight association with the monolayer but the effects were small. These experiments provided evidence to suggest that physical interactions and aggregations are unlikely to be a major contributing mechanism of the inhibitory effects of BPs on environmental mutagens.Chemical reactions between BPs and the DNA modifying metabolites of mutagens (epoxides) were studied using styrene epoxide as a model for the reactive metabolites. Styrene epoxide is commercially available, stable and less toxic than the reactive metabolites of the mutagens.Competitive reactions were performed in which BPs and their derivatives were placed in solution with guanine and allowed to react with styrene epoxide. These reactions showed that BPs and their dimethyl esters are more reactive to the epoxide than guanine. Bile pigments primarily react through their carboxylic acid groups with the mono-and di-styrene epoxide esters being the major products isolated form the reactions. The pyrrole rings in bilirubin also showed some evidence of iii reaction with styrene epoxide though the products were too unstable to isolate. Thus, it was clear that BPs can effecti...

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Highly Sensitive Detection of Residual Chlorpromazine Hydrochloride with Solid Substrate Room Temperature Phosphorimetry

Cited by 5 publications

References 5 publications

Determination of Chlorpromazine Hydrochloride with a Layered Double Hydroxide Modified Glassy Carbon Electrode as a Nanocatalyst

Determination of Chlorpromazine Hydrochloride with a Layered Double Hydroxide Modified Glassy Carbon Electrode as a Nanocatalyst

A Novel Solid Substrate Room Temperature Phosphorimetry for the Determination of Trace Cytochrome C and Forecast of Human Diseases

Physical and chemical interactions between bile pigments and polyaromatic mutagens

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