Highly Sensitive Determination of Atropine in Pharmaceuticals, Biological Fluids and Beverage on Planar Electrochemical Cell with Working Boron-Doped Diamond Electrode

Dushna, Olha; Dubenska, Liliya; Vojs, Marián; Marton, Marián; Patsay, Igor; Ivakh, Sophia; Plotycya, Serhiy

doi:10.1016/j.electacta.2022.141182

Cited by 22 publications

(9 citation statements)

References 58 publications

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“…Frequently used electrode materials are the glassy carbon electrode (GCE), carbon disk electrode (CDE), saturated calomel electrode (SCE), and boron-doped diamond electrode (BDDE). 106,107 The electrochemical methods for alkaloid detection like differential pulse voltammetry, the hyphenated technique of capillary electrophoresis with mass spectrometry, cyclodextrin-modified capillary electrophoresis, and cyclodextrin-modified micellar electrokinetic chromatography are highly sensitive, simple, and rapid methods which give good results. [106][107][108] T A B L E 1 3 Various immunosensors and electrochemical methods for the detection of alkaloids.…”

Section: Immunosensors and Electrochemical Techniques For The Detecti...mentioning

confidence: 99%

“…106,107 The electrochemical methods for alkaloid detection like differential pulse voltammetry, the hyphenated technique of capillary electrophoresis with mass spectrometry, cyclodextrin-modified capillary electrophoresis, and cyclodextrin-modified micellar electrokinetic chromatography are highly sensitive, simple, and rapid methods which give good results. [106][107][108] T A B L E 1 3 Various immunosensors and electrochemical methods for the detection of alkaloids. Glaucine and tetrahydropalmatine were analyzed in urine samples using electrochemical methods [111]…”

Section: Immunosensors and Electrochemical Techniques For The Detecti...mentioning

confidence: 99%

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An insight into recent updates on analytical techniques for bioactive alkaloids

Saini,

Seni,

Chawla

et al. 2024

Phytochemical Analysis

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IntroductionAlkaloids represent a wide class of naturally existing nitrogen‐containing organic compounds having diverse biological activities. They are primary bioactive substances extracted from diverse plant parts. Due to their diverse biological activities, they are frequently used as medicines. The alkaloids have diverse pharmacological impacts on the human body; alkaloids are used for prevention, treatment, and reduction of discomfort associated with chronic illnesses. As most alkaloids exist in plants in complex form, combined with numerous other natural plant components, it is essential to recognize and characterize these molecules using different analytical techniques.ObjectivesWe aimed to review the literature on the methods and protocols for the analysis of naturally occurring alkaloids.MethodsWe carried out a literature survey using the PubMed, Scopus, and Google Scholar databases and other relevant published materials. The keywords used in the searches were “alkaloids,” “analytical methods,” “HPLC method,” “GC method,” “electrochemical methods,” and “bioanalytical methods,” in various combinations.ResultsIn this article, several classes of alkaloids are presented, along with their biological activities. Moreover, it includes a thorough explanation of chromatographic techniques, hyphenated techniques, electrochemical techniques, and current trending analytical methods utilized for the isolation, identification, and comprehensive characterization of alkaloids.ConclusionsThe various analytical techniques play an important role in the identification as well as the characterization of various alkaloids from plants, plasma samples, and urine samples. The hyphenation of various chromatographic techniques with mass spectrometry and NMR spectroscopy plays a crucial role in the characterization of unknown compounds.

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Section: Immunosensors and Electrochemical Techniques For The Detecti...mentioning

confidence: 99%

Section: Immunosensors and Electrochemical Techniques For The Detecti...mentioning

confidence: 99%

An insight into recent updates on analytical techniques for bioactive alkaloids

Saini,

Seni,

Chawla

et al. 2024

Phytochemical Analysis

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“…For example, Henderson Skye et al [20] investigated the preparation of nanoparticles and Nafionmodified boron-doped gold BDD microelectrodes and their application in the in vitro detection of nitric oxide ( NO ) in mouse colon; Boonkaew Suchanat et al [21] proposed boron/nitrogen co-doped diamond-graphene nanowall-structured ( DGNW ) integrated with screen-printed graphene electrode ( SPGE ) for the detection of serotonin ( 5-HT ) as a model system and applied the method to synthetic urine samples, the results showed that the DGNW modified electrode has good anti-pollution properties and biocompatibility; while Dushna Olha et al [22] firstly combined a working boron-doped diamond electrode ( BDDE ) with a novel screen-printed sensor to form a planar electro chemical cell consisting of a working boron-doped diamond electrode ( BDDE ) and a novel screen-printed sensor was first used for voltammetric determination of the alkaloid atropine (ATR).…”

Section: Detection Of Trace Organic Compound Componentsmentioning

confidence: 99%

Research and Application Progress of Boron-doped Diamond Films

Hou¹,

Ye²,

Han³

et al. 2023

HSET

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Thanks to its unique structure, diamond has many excellent properties, such as high hardness, low birefringence, high thermal conductivity, good chemical stability, etc., but pure diamond has extremely high resistivity (up to 1012 Ω∙m ), which is an insulator, so it is usually doped to expand the application of diamond in the electrochemical field. B atoms have a very small radius, which is an ideal material for doping diamond, and B-doped diamond has good electrical conductivity. In this paper, on the basis of introducing the phase composition and structure of boron-doped diamond (BDD) film, the common methods for preparing BDD film are analyzed, and the application status and prospect of its application in electrochemistry and other fields are summarized.

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“…On the other hand, colorimetric tests can offer portable and low-cost analysis, but they are often not viable for decision-making, serving only as a preliminary test, resulting in false positives due to lack of selectivity . In this context, electrochemical methods can overcome these drawbacks by offering versatile, cheap, and portable sensors, meeting the needs of the police for field analysis. − …”

Section: Introductionmentioning

confidence: 99%

Additive Manufacturing of a Portable Electrochemical Sensor with a Recycled Conductive Filament for the Detection of Atropine in Spiked Drink Samples

Arantes,

Crapnell,

Whittingham

et al. 2023

ACS Appl. Eng. Mater.

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Additive manufacturing (three-dimensional (3D) printing) has promising features for fast prototyping electrochemical systems, from cells to sensors. Conductive filaments containing carbon black and poly(lactic acid) (CB/PLA) for electrode fabrication are commercially available but usually rely on low carbon content, resulting in poor electrochemical properties. Filament fabrication can be done within the laboratory by exploring different materials according to the desired applications. In this work, recycled PLA was used as the thermoplastic base polymer, alongside CB as the conductive filler, and tris (2ethylhexyl) trimellitate was introduced into the filament matrix as a plasticizer (CB/PLA/ TTM) to fabricate additively manufactured electrodes (AMEs). This enhanced the electrochemical properties toward different redox probes and the forensic target atropine. Thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS) were used to characterize the filament and AMEs before and after activation. Additive manufacturing has also been used to develop different cell configurations, which is equally important for good electroanalytical performance. Flow analytical techniques, such as batch-injection analysis (BIA), can be used as an alternative to stationary measurements to enhancing sensitivity and detection limits (LOD) via increasing the mass transport of analytes to the electrochemical platform surface, providing automation and high sample throughput. In this context, we developed a compact (∼5 mL capacity) and versatile additively manufactured BIA cell that can either perform static or hydrodynamic analyses by simply placing a lid on the device with a hole for the BIA pipette tip. Moreover, knowing that forensic chemistry necessitates portable analytical tools to help police investigation at the crime scene, the AM-BIA cell and the bespoke AMEs were coupled to a portable electrochemical apparatus for on-site atropine analysis in adulterated beverage samples. Atropine determination was performed by differential pulse voltammetry (DPV) and amperometry (BIA-AMP) in the same cell, presenting good repeatability for both methods (6% RSD). As expected, the BIA-AMP method showed higher sensitivity (0.0783 μA μM −1 ) and lower LOD (0.51 μM) compared to the stationary DPV method (sensitivity: 0.0148 μA μmol −1 L; LOD: 2.60 μM); they both presented good recovery values, varying from 102 to 109% for two spiked samples of gin and whisky. Thus, the versatility and portability of the developed AM-BIA cell coupled with the bespoke filament CB/PLA/TTM allow for rapid and accurate screening and quantification of atropine in real forensic scenarios.

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Highly Sensitive Determination of Atropine in Pharmaceuticals, Biological Fluids and Beverage on Planar Electrochemical Cell with Working Boron-Doped Diamond Electrode

Cited by 22 publications

References 58 publications

An insight into recent updates on analytical techniques for bioactive alkaloids

An insight into recent updates on analytical techniques for bioactive alkaloids

Research and Application Progress of Boron-doped Diamond Films

Additive Manufacturing of a Portable Electrochemical Sensor with a Recycled Conductive Filament for the Detection of Atropine in Spiked Drink Samples

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