Highly sensitive electrochemical sensor determination of drug in pharmaceutical analysis

Abstract

M ODIFED carbon paste electrodes and screen printed electrodes were developed for the potentiometric determination of butenaFne hydrochloride (BTFHC) in urine, serum and pharmaceutical preparations. Two modiFed carbon paste electrodes (electrodes A and C) and two modiFed screen printed electrodes (electrodes B and D) using tricresylphosphate (TCP) and o-nitrophenyloctyl ether (o-NPOE) plasticizers, respectively, were used. The electrodes showed a linear concentration range from 1.57×10-7 to 1.0 × 10-2 and 1.0 × 10-7 to 1.0 × 10-2 mol L-1 with detection limit of 1.57×10-7 and 1.0 × 10-7 mol L-1 for modiFed carbon paste (MCPEs; electrodes A and B) and modiFed screen printed (MSPEs; electrodes C and D), respectively. The calibration graphs have slope values of 56.95±0.56, 58.22±0.78, 56.18±0.66 and 57.69±0.39 mV decade-1 for electrodes A, B, C and D, respectively. The response time was relatively quick in the whole concentration range and was found to be 12s for electrodes (A and B) and 7s for electrodes (C and D). The electrodes were found to have life time of 82, 99, 160 and 185 days without showing any deviations in a pH range of 5.0-9.0 and 4.0-9.0 for MCPEs (electrodes A and B) and MSPEs electrodes (C and D), respectively. The fabricated electrodes displayed good selectivity for BTFHC with respect to number of common foreign inorganic cations, sugar species, organic and glycine as the Fllers that may be added to the pharmaceutical preparation or biological fluids. Fortunately, such materials mostly do not interfere. The potential application of the sensors (A-D) was accomplished as a result of good recoveries made from real samples fortiFed with BTFHC. Results indicated the proFciency of the sensors reliable for rapid, onsite monitoring of BTFHC in pharmaceutical preparation and in biological samples.

Sensitive and effective electrochemical determination of butenafine in the presence of itraconazole using titanium nanoparticles-ionic liquid based nanocomposite sensor

“…To best of our knowledge, different analytical techniques were used to determine BTH including HPLC (Ankam et al 2009 ; Bhosale and Rajput 2011 ; Miron et al 2014 ), LC (Barth et al 2011a , 2011b ; Song et al 2011 ), and potentiometric methods (Ali et al 2020 ; Frag etal. 2020 ).…”