Highly sensitive Love wave acoustic biosensor for uric acid

Rana, Lokesh; Gupta, Vinay; Tomar, Monika; Gupta, Vinay

doi:10.1016/j.snb.2018.01.122

Cited by 54 publications

(24 citation statements)

References 29 publications

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“…Surface acoustic wave (SAW) devices have received extensive interest for sensor applications owing to their small size, high sensitivity and ability to interface with passive wireless systems [1][2][3][4][5][6]. SAW devices can be developed into highly sensitive sensors for continuously monitoring of hazardous and flammable gases in the sub-ppm regime if integrating with specifically designed sensing materials which are sensitive to a certain type of gas.…”

Section: Introductionmentioning

confidence: 99%

Colloidal quantum dot-based surface acoustic wave sensors for NO2-sensing behavior

Kan

Chen

et al. 2019

Sensors and Actuators B: Chemical

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Section: Introductionmentioning

confidence: 99%

Colloidal quantum dot-based surface acoustic wave sensors for NO2-sensing behavior

Kan

Chen

et al. 2019

Sensors and Actuators B: Chemical

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“…In this case, the SAW sensor structure is modified to adapt it to operation in a liquid environment, to avoid strong damping of the surface wave in the presence of liquid media [11,14]. A guiding layer is deposited on top of the piezoelectric substrate, which traps the acoustic energy near the sensing surface, ensuring operation in contact with liquid media and increasing sensitivity [15]. A LW is a horizontally polarized shear wave which is guided in a layer with a shear velocity lower than the piezoelectric substrate, and propagates in the guiding layer and in the part of the substrate close to the interface.…”

Section: Introductionmentioning

confidence: 99%

Love Wave Surface Acoustic Wave Sensor with Laser-Deposited Nanoporous Gold Sensitive Layer

Viespe

Dinca

Popescu-Pelin

et al. 2019

Sensors

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Laser-deposited gold immobilization layers with different porosities were incorporated into Love Wave Surface Acoustic Wave sensors (LW-SAWs). Acetylcholinesterase (AChE) enzyme was immobilized onto three gold interfaces with different morphologies, and the sensor response to chloroform was measured. The response of the sensors to various chloroform concentrations indicates that their sensing properties (sensitivity, limit of detection) are considerably improved when the gold layers are porous, in comparison to a conventional dense gold layer. The results obtained can be used to improve properties of SAW-based biosensors by controlling the nanostructure of the gold immobilization layer, in combination with other enzymes and proteins, since the design of the present sensor is the same as that for a Love Wave biosensor.

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“…[4], aptamers [5], tissue slides [6] and microorganisms [7] have been combined with a wide range of transducers such as amperometric [8], impedimetric [9], piezoelectric, acoustic [10], potentiometric [11], fluorescent [12] and colorimetric [13]. Antibodies have been abundantly used in the fabrication of biosensors named "immunosensors", thanks to their ability to detect a specific antigen [14].…”

Section: Introductionmentioning

confidence: 99%

Development of a functional impedimetric immunosensor for accurate detection of thy- roid-stimulating hormone

Asav¹

2021

Turk J Chem

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Thyroid-stimulating hormone (TSH) that regulates the synthesis of thyroid gland hormones controlling all metabolism is one of the pituitary hormones. Determination of TSH is crucial for monitoring thyroid gland-related disorders and some metabolic diseases.In this study, a non-labeled immunosensor based on covalent immobilization of anti-TSH antibody by using the formation of self-assembled monolayers (SAM) of 4mercaptophenylacetic acid (4-MPA) and functionalization of carboxyl ends with 1ethyl-3-(3-dimetilaminopropil) carbodiimide (EDC)/N-Hydroxysuccinimide (NHS) was fabricated for detection of TSH. Immobilization steps including the concentration of 4-2 MPA, the concentration of anti-TSH antibody and duration of anti-TSH antibody incubation were optimized by utilizing electrochemical impedance spectroscopy. Under optimal conditions, a sensitive, rapid and accurate determination of TSH at a concentration range between 0.7 -3.5 mIU/L was accomplished with a notable linearity and LOD value as 0.034 mIU/L as well as reproducibility and repeatability. Moreover, for comparison, linear range experiments were also carried out by using other electrochemical methods including Linear Sweep Voltammetry (LSV), Cyclic Voltammetry (CV) and capacitance spectroscopy (C). Finally, the constructed immunosensor was used for analyzing TSH levels spiked in the artificial serum samples.

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Highly sensitive Love wave acoustic biosensor for uric acid

Cited by 54 publications

References 29 publications

Colloidal quantum dot-based surface acoustic wave sensors for NO2-sensing behavior

Colloidal quantum dot-based surface acoustic wave sensors for NO2-sensing behavior

Love Wave Surface Acoustic Wave Sensor with Laser-Deposited Nanoporous Gold Sensitive Layer

Development of a functional impedimetric immunosensor for accurate detection of thy- roid-stimulating hormone

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