Highly Sensitive Nonenzymatic Cholesterol Sensor Based on Zinc Oxide Nanorods

Anh, Ta Thi Nhat; Hoang, Lan; Tam, Le Thi; Pham, Vuong-Hung; Tam, Phuong Dinh

doi:10.1007/s11664-018-6568-z

Cited by 20 publications

(10 citation statements)

References 27 publications

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“…In comparison of other electrodes, the NiCo 2 S 4 @NF electrode shows the best linear fitting with a correlation coefficient of R 2 = 0.999. The reproducible sensitivity of NiCo 2 S 4 @NF electrode was calculated to be 8623.6 μA mM −1 cm −2 and found to be superior as compared to the other electrodes and the previously reported values [37][38][39][40][41][42][43][44][45] as shown in table 1. The improved electrocatalytic activity of NiCo 2 S 4 @NF electrode is considered due to the result of large surface area and flakes like morphology of NiCo 2 S 4 structure.…”

Section: Morphological Structural and Compositional Analysismentioning

confidence: 52%

Mesoporous NiCo₂S₄ nanoflakes as an efficient and durable electrocatalyst for non-enzymatic detection of cholesterol

Rabbani¹,

Nisar²,

Zafar³

et al. 2022

Nanotechnology

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The detection of cholesterol is very crucial in clinical diagnosis for rapid and accurate monitoring of multiple disease-biomarkers. There is a great need for construction of a highly reliable and stable electrocatalyst for the efficient detection of cholesterol. In this work, mesoporous NiCo2S4 nanoflakes of enhanced electrochemical properties are prepared through a facile hydrothermal approach. The developed nanoflakes modified nickel foam electrode exhibits outstanding electrocatalytic properties for the detection of cholesterol with high selectivity. The electrode displays excellent sensitivity of 8623.6 μA mM−1 cm−2, in the wide linear range from 0.01 to 0.25 mM with a low detection limit of 0.01 μM. In addition, NiCo2S4 structure reveals good thermal stability and reproducibility over a period of 8 weeks. Moreover, the nanoflakes show good response for detection of cholesterol in real samples. Our results demonstrate the potential use of NiCo2S4 as a catalyst for the development of cost-effective electrochemical sensors for medical and industrial applications.

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Section: Morphological Structural and Compositional Analysismentioning

confidence: 52%

Mesoporous NiCo₂S₄ nanoflakes as an efficient and durable electrocatalyst for non-enzymatic detection of cholesterol

Rabbani¹,

Nisar²,

Zafar³

et al. 2022

Nanotechnology

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“…The chemical properties and organization of ZnO NRs can be modulated by the synthesis procedure, influencing their ability to adsorb biomolecules. When aiming for biosensor applications, ZnO NRs are typically prepared by a hydrothermal procedure 7 , 9 , 10 ; however, this method requires the use of high temperature and pressure, limiting its use on flexible polymeric materials. Electrodeposition is an alternative and affordable method that can also deliver high-quality ZnO NRs 11 .…”

Section: Introductionmentioning

confidence: 99%

“…ZnO-based nanoplatforms are commonly used to adsorb low molecular molecules, like glucose 10 and cholesterol 9 , but are also used to bind specific proteins, such as troponin 14 . ZnO nanoplatforms are also used, although to a smaller extent, to bind larger particles, such as viruses and bacteria 2 , 7 .…”

Section: Introductionmentioning

confidence: 99%

Flexible ZnO-mAb nanoplatforms for selective peripheral blood mononuclear cell immobilization

Babu

Pinheiro

Marques

et al. 2020

Sci Rep

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Cancer is the second cause of death worldwide. This devastating disease requires specific, fast, and affordable solutions to mitigate and reverse this trend. A step towards cancer-fighting lies in the isolation of natural killer (NK) cells, a set of innate immune cells, that can either be used as biomarkers of tumorigenesis or, after autologous transplantation, to fight aggressive metastatic cells. In order to specifically isolate NK cells (which express the surface NKp30 receptor) from peripheral blood mononuclear cells, a ZnO immunoaffinity-based platform was developed by electrodeposition of the metal oxide on a flexible indium tin oxide (ITO)-coated polyethylene terephthalate (PET) substrate. The resulting crystalline and well-aligned ZnO nanorods (NRs) proved their efficiency in immobilizing monoclonal anti-human NKp30 antibodies (mAb), obviating the need for additional procedures for mAb immobilization. The presence of NK cells on the peripheral blood mononuclear cell (PBMCs) fraction was evaluated by the response to their natural ligand (B7-H6) using an acridine orange (AO)-based assay. The successful selection of NK cells from PBMCs by our nanoplatform was assessed by the photoluminescent properties of AO. This easy and straightforward ZnO-mAb nanoplatform paves the way for the design of biosensors for clinic diagnosis, and, due to its inherent biocompatibility, for the initial selection of NK cells for autotransplantation immunotherapies.

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“…However, the maximum current drops when the pH is greater than 7.2. This characteristic of the current response shows that the acidic and basic systems inhibit the activity of the electrode, hence inhibiting the response. , Therefore, pH 7.2 was chosen as the optimum pH for Cho determination.…”

Section: Resultsmentioning

confidence: 99%

Radix Pueraria Flavonoids Assisted Green Synthesis of Reduced Gold Nanoparticles: Application for Electrochemical Nonenzymatic Detection of Cholesterol in Food Samples

et al. 2022

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Using radix pueraria flavonoids (RPFs) as a reducing and stabilizing agent, we report a simple, cost-effective, and ecologically friendly green synthesis technique for gold nanoparticles (AuNPs) in the present study. Ultraviolet−visible (UV) spectroscopy, transmission electron microscopy (TEM), Fourier transform infrared (FTIR), and X-ray diffraction (XRD) investigations were used to characterize the AuNPs. The results demonstrated that the produced AuNPs were nearly spherical and that their particle sizes had a mean diameter of 4.85 ± 0.75 nm. The "Green" AuNPs, exhibiting remarkable peroxidase-like activity and Michaelis−Menten kinetics with high affinity for H 2 O 2 and 3,3′,5,5′-tetramethylbenzidine (TMB), were effectively applied to the fabrication of a sensitive nonenzymatic enhanced electrochemical sensor for the detection of cholesterol (Cho). Under optimum circumstances, it was possible to establish two linear ranges of 1−100 and 250−5000 μmol/L with a detection limit of 0.259 μmol/L (signal/noise ratio (S/N) = 3). The suggested sensor was utilized with satisfactory findings to determine the amount of Cho in food samples.

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Highly Sensitive Nonenzymatic Cholesterol Sensor Based on Zinc Oxide Nanorods

Cited by 20 publications

References 27 publications

Mesoporous NiCo₂S₄ nanoflakes as an efficient and durable electrocatalyst for non-enzymatic detection of cholesterol

Mesoporous NiCo₂S₄ nanoflakes as an efficient and durable electrocatalyst for non-enzymatic detection of cholesterol

Flexible ZnO-mAb nanoplatforms for selective peripheral blood mononuclear cell immobilization

Radix Pueraria Flavonoids Assisted Green Synthesis of Reduced Gold Nanoparticles: Application for Electrochemical Nonenzymatic Detection of Cholesterol in Food Samples

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Highly Sensitive Nonenzymatic Cholesterol Sensor Based on Zinc Oxide Nanorods

Cited by 20 publications

References 27 publications

Mesoporous NiCo2S4 nanoflakes as an efficient and durable electrocatalyst for non-enzymatic detection of cholesterol

Mesoporous NiCo2S4 nanoflakes as an efficient and durable electrocatalyst for non-enzymatic detection of cholesterol

Flexible ZnO-mAb nanoplatforms for selective peripheral blood mononuclear cell immobilization

Radix Pueraria Flavonoids Assisted Green Synthesis of Reduced Gold Nanoparticles: Application for Electrochemical Nonenzymatic Detection of Cholesterol in Food Samples

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Mesoporous NiCo₂S₄ nanoflakes as an efficient and durable electrocatalyst for non-enzymatic detection of cholesterol

Mesoporous NiCo₂S₄ nanoflakes as an efficient and durable electrocatalyst for non-enzymatic detection of cholesterol