Highly sensitive photoelectrochemical detection of bleomycin based on Au/WS2 nanorod array as signal matrix and Ag/ZnMOF nanozyme as multifunctional amplifier

Kong, Weisu; Guo, Xiaoxi; Jing, Man; Qu, Fengli; Lu, Limin

doi:10.1016/j.bios.2019.111875

Cited by 53 publications

(17 citation statements)

References 48 publications

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“…The prosper of Au nanozymes with intrinsic POD-like activity provided possibility to tune the functionalization of existing methods in analyzing multiple antibiotics (e.g., doxycycline [ 325 ], kanamycin [ 61 ], tetracycline [ 329 ]). Kong et al [ 330 ] designed a novel photo-electrochemistry (PEC) biosensor for bleomycin (BLM) detection, which was natural antibiotics for Hodgkin's disease, cervical cancer therapy. The biosensor reached a detection limit to 0.18 nM in which Ag/ZnMOF nanozymes acted as a signal amplifier and Au NPs/tungsten sulfide nanorod array (Au/WS 2 ) photoelectrode used as a PEC matrix (Fig.…”

Section: Applications Of Metal- and Metal Oxide-based Nanozymesmentioning

confidence: 99%

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress in nanozymes has been made with deep investigation of diverse nanozymes and rapid development of related nanotechnologies. As promising alternatives for natural enzymes, nanozymes have broadened the way toward clinical medicine, food safety, environmental monitoring, and chemical production. The past decade has witnessed the rapid development of metal- and metal oxide-based nanozymes owing to their remarkable physicochemical properties in parallel with low cost, high stability, and easy storage. It is widely known that the deep study of catalytic activities and mechanism sheds significant influence on the applications of nanozymes. This review digs into the characteristics and intrinsic properties of metal- and metal oxide-based nanozymes, especially emphasizing their catalytic mechanism and recent applications in biological analysis, relieving inflammation, antibacterial, and cancer therapy. We also conclude the present challenges and provide insights into the future research of nanozymes constituted of metal and metal oxide nanomaterials.

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Section: Applications Of Metal- and Metal Oxide-based Nanozymesmentioning

confidence: 99%

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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“…They exhibit great application potential in the fields of gas adsorption and separation, catalysis, sensing, biomedicine, and other fields. [171] For example, the hollow MOF and its derivatives shown excellent catalytic activity due to their hierarchical structure and multiple exposed metal active sites. In addition, introducing defects into the crystal structure of MOFs can finely adjust the structure of MOFs, so that the performance of MOFs can be further improved, Furthermore, defects of MOFs can even make them have functions that they did not have before.…”

Section: Metal-organic Framework-based Nanozymesmentioning

confidence: 99%

“…There are many applications of nanozymes in the field of biosensing, especially for the detection of some important biological target molecules, such as blood glucose, glutathione, phosphatase, uric acid, ROS, and the like. [102,171,220] For example, Dong et al used the 3D porous graphene supported Fe 3 O 4 hybrid for detection of glucose. [221] Similarly, Yao et al reported the CeO 2 @ MnO 2 core-shell nanozyme for photoelectrochemical sensing of glucose.…”

Section: Nanozyme For Biosensingmentioning

confidence: 99%

Recent Advances in Nanozymes: From Matters to Bioapplications

Liang

et al. 2021

Adv Funct Materials

250

115

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The manufacture of bionic materials to simulate the natural counterparts has attracted extensive attention. As one of the subcategories of biomimetic materials, the development of artificial enzyme is intensive pursuing. As a kind of artificial enzyme, nanozymes are dedicated to solve the limitations of natural enzymes. In recent years, attributed to the explosive development of nanotechnology, biotechnology, catalysis science, computational design and theory calculation, research on nanozymes has made great progress. To highlight these achievements and help researchers to understand the current investigation status of nanozyme, the state‐of‐the‐art development in nanozymes from fabrication materials to bioapplications are summarized. First different raw materials are summarized, including metal‐based, metal‐free, metal‐organic frameworks‐based, and some other novel matters, which are applied to fabricate nanozymes. The different types of enzymes‐like catalytic activities of nanozymes are briefly discussed. Subsequently, the wide applications of nanozymes such as anti‐oxidation, curing diseases, anti‐bacteria, biosensing, and bioimaging are discussed. Finally, the current challenges faced by nanozymes are outlined and the future directions for advancing nanozyme research are outlooked. The authors hope this review can inspire research in the fields of nanotechnology, chemistry, biology, materials science, and theoretical computing, and can contribute to the development of nanozymes.

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“…AuNR functionalisation with nucleic acids [99,100] as well as antibodies [93,101,102] has been widely reported. Kong's group developed a neoteric and cost-efficient sensor for the detection of bleomycin, a drug commonly administered in the treatment of lymphoma, ovarian as well as testicular cancer [103]. The sensor was fabricated using a composite of tungsten sulphide nanorod array on titanium mesh with DNA functionalised AuNPs (size = 18 ± 1 nm) as a sensor platform and a multiplexed signal amplifier in the form of a nanohybrid of AgNPs (lattice spacing = 0.27 nm) and zinc metal-organic framework nanozyme.…”

Section: Localised Surface Plasmon Resonance Sensors For Biomedical Dmentioning

confidence: 99%

Recent Progress in Optical Sensors for Biomedical Diagnostics

2020

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In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject. Optical sensors show versatility amongst different receptor types and even permit the integration of different detection mechanisms. Such conjugated sensing platforms facilitate the exploitation of their neoteric synergistic characteristics for sensor fabrication. This paper covers nearly 250 research articles since 2016 representing the emerging interest in rapid, reproducible and ultrasensitive assays in clinical analysis. Therefore, we present an elaborate review of biomedical diagnostics with the help of optical sensors working on varied principles such as surface plasmon resonance, localised surface plasmon resonance, evanescent wave fluorescence, bioluminescence and several others. These sensors are capable of investigating toxins, proteins, pathogens, disease biomarkers and whole cells in varied sensing media ranging from water to buffer to more complex environments such as serum, blood or urine. Hence, the recent trends discussed in this review hold enormous potential for the widespread use of optical sensors in early-stage disease prediction and point-of-care testing devices.

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Highly sensitive photoelectrochemical detection of bleomycin based on Au/WS2 nanorod array as signal matrix and Ag/ZnMOF nanozyme as multifunctional amplifier

Cited by 53 publications

References 48 publications

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Recent Advances in Nanozymes: From Matters to Bioapplications

Recent Progress in Optical Sensors for Biomedical Diagnostics

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