Highly sensitive SERS detection of residual nitrofurantoin and 1‐amino‐hydantoin in aquatic products and feeds

Abstract

Nitrofurantoin (NFT), a typical highly effective nitrofuran antibiotic drug, has been prohibited but still widely found in animal food products. It can be metabolized in animals to form 1‐amino‐hydantoin (AHD) that can then form stable and toxic metabolite‐protein adducts. Hence, the detection of NFT and AHD in aquatic products and feeds is very important. However, there are limited reports concerning NFT detection and none about AHD by using surface‐enhanced Raman spectroscopy (SERS) method. Herein, potassium bromide (KBr) decorated silver (Ag) nanoparticles (Ag‐BrNPs)‐based SERS approach was proposed for NFT and AHD detection. The limit of detection (LOD) for NFT was 1 μg/L. The detection of NFT residues in sea cucumber and fish feeds was also realized with the LOD of 1 and 50 ng/g, respectively. More importantly, the sensing of AHD was easily realized with the SERS approach for the first time. After the derivatization with 2‐nitrobenzaldehyde (2‐NBA), Ag‐BrNPs were also successfully utilized for AHD detection in sea cucumber with the LOD of 5 ng/g.

Halogen ion‐modified silver nanoparticles for ultrasensitive surface‐enhanced Raman spectroscopy detection of polycyclic aromatic hydrocarbons

“…As shown in Figure 3, the Phe signal (at 711 cm −1 ) increased initially (5–20 mM) and then reduced (20–100 mM) with increase in KBr concentration. The competitive adsorption of KBr at much higher concentrations is believed to push Phe molecules away from the surface of the Ag NPs, [ 30 ] resulting in decreased SERS performance. Therefore, 50 μl of 20 mM KBr was selected for subsequent experiments.…”

Detection of nitrofurans residues in honey using surface‐enhanced Raman spectroscopy

“…Compared with Raman spectra of pure samples, SERS spectra of nitrofurantoin‐containing honey had distinct peaks at 1025, 1179, 1256, 1353, 1501, and 1612 cm −1 . The most intense SERS peaks of nitrofurantoin‐containing honey were: (i) 1612 cm −1 , assigned to the in‐plane symmetric vibration of C = N and the stretching vibration of C = O; (ii) 1353 cm −1 , assigned to the stretch and wag vibrations of H–C–H and furan ring; (iii) 1025 cm −1 , assigned to the stretch vibration of C‐C and C‐O; (v) 1256 cm −1 , assigned to in‐plane bending of C–H; (iv) 1501 cm −1 assigned to the in‐plane stretch vibration of the furan ring (Fan et al., 2022; Wu et al., 2020; Xie et al., 2012; H. Zhang et al., 2020). Due to fluorescence (Frausto‐Reyes et al., 2017), the Raman characteristic signal of honey was very weak, with signals only before 1000 cm −1 .…”

“…Trace amounts of nitrofurantoin in mouthwash and rose mist could be detected and quantified at 1.77 and 7.74 mg/L, respectively, with recovery rate of 86.8-106% and relative standard deviations of 0.9-2.9%. Fan et al (2022) detected nitrofurantoin and its derivative 1-aminohydantoin in animals using SERS based on potassium bromide-modified silver Nps( AgNPs). The detection limit of nitrofurantoin was 1 mg/L in standard solution, whereas the detection limit of nitrofurantoin residues in sea cucumber and fish feed was 1 and 50 ng/g, respectively.…”

“…Fan et al. (2022) detected nitrofurantoin and its derivative 1‐aminohydantoin in animals using SERS based on potassium bromide‐modified silver Nps( AgNPs). The detection limit of nitrofurantoin was 1 mg/L in standard solution, whereas the detection limit of nitrofurantoin residues in sea cucumber and fish feed was 1 and 50 ng/g, respectively.…”

Boosting bacteria differentiation efficiency with multidimensional surface‐enhanced Raman scattering: the example of Bacillus cereus

“…However, the high cost of reagents and the unsatisfactory detection speed are unavoidable problems. [4] Surface-enhanced Raman scattering (SERS) as a highly sensitive, nondestructive, and convenient sensing method [5][6][7] has been widely used in food safety, [8,9] biomedicine, [10][11][12] and environmental analysis. [13][14][15][16] In addition, the use of SERS to identify bacteria with complex biological components has also been reported.…”