Highly sensitive SERS detection of IL-6 in serum by Au@Fe3O4 nanoring-based sandwich immunoassay

Optical Nanobiosensor-Based Point-of-Care Testing for Cardiovascular Disease Biomarkers

“…218 Qu et al demonstrated antibody 1 immobilized AuNPs@ Fe 3 O 4 nanoring and antibody 2 immobilized with Raman reporter 4-MBA@AgNPs probe-based sandwich SERS immunoassay for detection of IL-6 in serum, as shown in Figure 10d. 219 AuNPs@Fe 3 O 4 nanoring-based SERS immunoassay exhibited high selectivity of IL-6 in serum and the sensitivity range was 0.1−1000 pg/mL with obtained LOD of 0.028 pg/ mL. Similarly, Li et al 220 reported Fe 3 O 4 @Ag@Au bimetallic magnetic nancomposite immobilized with specific aptamerbased SERS substrate for the determination of cardiac troponin I, and the detected linear range was 0.01−100 ng/mL with an obtained LOD of 5.50 pg/mL.…”

The volatile release evaluation of nicotine from snus products under different storage conditions based on surface-enhanced Raman spectroscopy technology

“…[17][18][19][20][21][22] For many more substrates, especially practical SERS substrates, their current development needs to consider the characteristics of high reliability, fast operation, easy maintenance and portability. [23][24][25] Researchers found that binary nano-or micro-particles composed of a superparamagnetic core and Au or Ag nanoshell, such as Fe 3 O 4 microparticles coated with Au nanorods (Fe 3 O 4 @-AuNRs), 26 Fe 3 O 4 coated with Au nanoparticles (Fe 3 O 4 @-AuNPs), 27 etc., have a lot of advantages. [27][28][29] These nanoscale noble metal nanoshell-coated magnetic particles would be useful, especially in the SERS analysis of chemical species dissolved in aqueous solutions because the magnetic particles can be readily enriched from the solution by means of an external magnetic eld without centrifugation or ltration.…”

“…[23][24][25] Researchers found that binary nano-or micro-particles composed of a superparamagnetic core and Au or Ag nanoshell, such as Fe 3 O 4 microparticles coated with Au nanorods (Fe 3 O 4 @-AuNRs), 26 Fe 3 O 4 coated with Au nanoparticles (Fe 3 O 4 @-AuNPs), 27 etc., have a lot of advantages. [27][28][29] These nanoscale noble metal nanoshell-coated magnetic particles would be useful, especially in the SERS analysis of chemical species dissolved in aqueous solutions because the magnetic particles can be readily enriched from the solution by means of an external magnetic eld without centrifugation or ltration. Meanwhile, the binary SERS substrate combined with a capillary structure, [30][31][32] which is semi-closed, can be used as an embedded SERS substrate or for building micro circulation research.…”

“…17–22 For many more substrates, especially practical SERS substrates, their current development needs to consider the characteristics of high reliability, fast operation, easy maintenance and portability. 23–25 Researchers found that binary nano- or micro-particles composed of a superparamagnetic core and Au or Ag nanoshell, such as Fe 3 O 4 microparticles coated with Au nanorods (Fe 3 O 4 @AuNRs), 26 Fe 3 O 4 coated with Au nanoparticles (Fe 3 O 4 @AuNPs), 27 etc. , have a lot of advantages.…”

“…, have a lot of advantages. 27–29 These nanoscale noble metal nanoshell-coated magnetic particles would be useful, especially in the SERS analysis of chemical species dissolved in aqueous solutions because the magnetic particles can be readily enriched from the solution by means of an external magnetic field without centrifugation or filtration. Meanwhile, the binary SERS substrate combined with a capillary structure, 30–32 which is semi-closed, can be used as an embedded SERS substrate or for building micro circulation research.…”