Highly sensitive SERS substrates with multi-hot spots for on-site detection of pesticide residues

Xie, Tianhua; Cao, Zijin; Li, Yuejing; Li, Zhiyan; Zhang, Fan‐Li; Gu, Yingqiu; Han, Caiqin; Yang, Guohai; Qu, Lulu

doi:10.1016/j.foodchem.2022.132208

Cited by 69 publications

(20 citation statements)

References 38 publications

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“…Thus, the flexible and transparent SERS substrates possess unprecedented functionality featuring fast and in situ SERS analysis, such as on-site detection of pesticide residues in fruits and vegetables and realtime monitoring of nicotine in human skin. 22,23 Especially, if they are further integrated with a portable Raman instrument and wireless communication technology, the flexible and transparent SERS substrates could provide on-site and realtime detection of analytes in nonlaboratory settings to meet the increasing demand for POCT. Among various flexible matrixes, PDMS has been widely used to fabricate flexible SERS substrates due to its excellent flexibility, optical transparency, nontoxicity, and good stretchability.…”

Section: Introductionmentioning

confidence: 99%

“…The flexibility and the optical transparency allow the SERS substrates to conformally contact complex surfaces and conduct in situ detection, respectively. Thus, the flexible and transparent SERS substrates possess unprecedented functionality featuring fast and in situ SERS analysis, such as on-site detection of pesticide residues in fruits and vegetables and real-time monitoring of nicotine in human skin. , Especially, if they are further integrated with a portable Raman instrument and wireless communication technology, the flexible and transparent SERS substrates could provide on-site and real-time detection of analytes in nonlaboratory settings to meet the increasing demand for POCT.…”

Section: Introductionmentioning

confidence: 99%

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3D Flexible SERS Substrates Integrated with a Portable Raman Analyzer and Wireless Communication for Point-of-Care Application

Zhang

Zhao

et al. 2022

ACS Appl. Mater. Interfaces

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With the development of flexible surface-enhanced Raman spectroscopy (SERS) substrates that can realize rapid in situ detection, the SERS technique accompanied by miniaturized Raman spectrometers holds great promise for point-of-care testing (POCT). For an in situ detection strategy, constructing high-performance flexible and transparent SERS substrates through a facile and cost-effective fabrication method is critically important. Herein, we present a simple method for fabricating a large-area flexible and transparent SERS substrate consisting of a silver-nanoparticle-grafted wrinkled polydimethylsiloxane (Ag NPs@W-PDMS) film, using a surface-wrinkling technique and magnetron sputtering technology. By characterizing rhodamine 6G as a probe molecule with a portable Raman spectrometer, the flexible SERS substrate shows a low detection limit (10–7 M), a high enhancement factor (6.11 × 106), and excellent spot–spot and batch–batch reproducibilities (9.0% and 4.2%, respectively). Moreover, the Ag NPs@W-PDMS substrate maintains high SERS activity under bending and twisting mechanical deformations of over 100 cycles, as well as storage in air for 30 days. To evaluate its practical feasibility, in situ detection of malachite green on apple and tomato peels is performed with a detection limit of 10–6 M. In addition, for point-of-care analysis, we develop a wireless transmission system to transmit the collected SERS spectral data to a computer in real time for signal processing and analysis. Therefore, the proposed Ag NPs@W-PDMS SERS substrate fabricated through a simple and mass-producible method, combined with the utilization of a portable Raman spectrometer and wireless communication, offers a promising opportunity to extend the SERS technique from the laboratory to POCT applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

3D Flexible SERS Substrates Integrated with a Portable Raman Analyzer and Wireless Communication for Point-of-Care Application

Zhang

Zhao

et al. 2022

ACS Appl. Mater. Interfaces

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“…To mitigate this, the synthesized NPs can be fixed on a solid substrate . Rather than transferring green Ag NPs synthesized in a colloidal form onto a solid substrate such as a functionalized glass slide, , direct reduction of NPs onto a solid substrate is effective in terms of generating plasmonic hot spots. − Sustainable processes and green materials are needed to directly fabricate SERS-active surfaces on the biodegradable substrates. Furthermore, in real-life applications, obtaining and understanding Raman signals are challenging.…”

Section: Introductionmentioning

confidence: 99%

Machine Learning-Assisted Pesticide Detection on a Flexible Surface-Enhanced Raman Scattering Substrate Prepared by Silver Nanoparticles

Şahin

Çelik

Çamdal

et al. 2022

ACS Appl. Nano Mater.

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Access to clean water is a pressing challenge affecting millions of lives and the aquatic body of the Earth. Sensitive detection of pollutants such as pesticides is particularly important to address this challenge. This study reports eco-friendly preparation of the surface-enhanced Raman scattering (SERS) substrate for machine learning-assisted detection of pesticides in water. The proposed SERS platform was prepared on a copy paper by reducing a silver salt using the extract of a natural plant, Cedrus libani. The fabricated SERS platform was characterized in detail using scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The high-density formation of silver nanoparticles with an average diameter of 41 nm on the surface of the paper enabled detection of analytes with a nanomolar level sensitivity. This SERS capability was used to collect Raman signals of four different pesticides in water: myclobutanil, phosmet, thiram, and abamectin. Raman spectra of the pesticides are highly complex, challenging accurate determination of the pesticide type. To overcome this challenge and distinguish pesticides, machine learning (ML) approach was used. The ML-mediated detection of harmful pesticides on a versatile, green, and inexpensive SERS platform appears to be promising for environmental applications.

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“…Typical SERS substrates are based on rigid substrates such as silicon and glass, which are not suitable for sample collection by physical wiping [20][21][22][23]. An enhanced substrate with good flexibility can maximize sample collection by wiping irregular surfaces, enabling in situ detection and broadening the application of SERS technology [24][25][26][27][28][29]. Flexible SERS substrates have attracted extensive attention from researchers [30].…”

Section: Introductionmentioning

confidence: 99%

In Situ Collection and Rapid Detection of Pathogenic Bacteria Using a Flexible SERS Platform Combined with a Portable Raman Spectrometer

Zhao

Dong

Wang

et al. 2022

IJMS

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This study aims to develop a simple, sensitive, low-cost, environmentally friendly and flexible surface-enhanced Raman scattering (SERS) platform, combined with a portable Raman spectrometer, for the rapid and on-site SERS detection of bacteria. Commercial tobacco packaging paper (TPP) with little background interference was used as a loading medium that effectively adsorbed Au nanoparticles and provided sufficient “hot spots”. This Au-tobacco packaging paper (Au-TPP) substrate used as a flexible SERS platform can maximize sample collection by wiping irregular surfaces, and was successfully applied to the on-site and rapid detection of pathogenic bacteria. Raman fingerprints of pathogenic bacteria can be obtained by SERS detection of spiked pork using wipeable Au-TPP, which verifies its value in practical applications. The results collected by SERS were further verified by polymerase chain reaction (PCR) results. It showed several advantages in on-site SERS detection, including accurate discrimination, simple preparation, easy operation, good sensitivity, accuracy and reproducibility. This study indicates that the established flexible SERS platform has good practical applications in pathogenic bacterial identification and other rapid detections.

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Highly sensitive SERS substrates with multi-hot spots for on-site detection of pesticide residues

Cited by 69 publications

References 38 publications

3D Flexible SERS Substrates Integrated with a Portable Raman Analyzer and Wireless Communication for Point-of-Care Application

3D Flexible SERS Substrates Integrated with a Portable Raman Analyzer and Wireless Communication for Point-of-Care Application

Machine Learning-Assisted Pesticide Detection on a Flexible Surface-Enhanced Raman Scattering Substrate Prepared by Silver Nanoparticles

In Situ Collection and Rapid Detection of Pathogenic Bacteria Using a Flexible SERS Platform Combined with a Portable Raman Spectrometer

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