Highly sensitive simultaneous quantification of buprenorphine and norbuprenorphine in human plasma by magnetic solid-phase extraction based on PpPDA/Fe3O4 nanocomposite and high-performance liquid chromatography

Analytical Approaches for the Determination of Buprenorphine, Methadone and Their Metabolites in Biological Matrices

“…This rapid and automatable method is a potential tool for routine quantification of BUP and its metabolites. Nevertheless, the most commonly employed sample pretreatment for the monitoring of BUP, MTD and their metabolites in biological matrices are liquid-liquid extraction (LLE) [18][19][20][21][22][23]26,40,47,49,50,[52][53][54]56,60,61,63,65,68,69,71,74,76,77,80,[88][89][90][91][92] and solid-phase extraction (SPE) [7,24,28,38,41,[43][44][45][46]48,55,68,72,73,75,[93][94][95]. The major benefits of LLE are its simplicity a...…”

“…Table 1 summarizes the details based on the use of LC techniques utilized for BUP and MTD measurement. LC can be coupled with ultraviolet (UV) [40][41][42][43]54], photodiode array detector (PAD) [40], fluorescence (FL) and electrochemical (EC) [29,38] MS detection [7,13,15,18,[23][24][25][26][27][28]49,50,52,56,[60][61][62]64,65,[68][69][70][71][72][73]88]. Reversed-phase columns (C 18 or C 8 columns) with spherical sorbent particles are popular for the determination of BUP, MTD and their metabolites.…”

“…The method was specific enough for the monitoring of serum MTD levels in cancer patients. Gomar et al [54] proposed a LC-UV method coupled with MSPE for the monitoring of BUP and its metabolites in human plasma samples. The MSPE technique was based on a poly para-phenylenediamine modified Fe 3 O 4 NPs (PpPDA/Fe 3 O 4 ), which greatly improved the extraction efficiency (>90%) and decreased the analysis time (<20 min).…”

“…Different biological specimens including urine [7,, plasma [13,20,21,35,38,40,[42][43][44][45][46][47][48][49][50][51][52][53][54][55], serum [30,[56][57][58][59], blood [15,18,22,49,[60][61][62][63], nails [64], oral fluid [17,31,55,[65][66][67][68][69], hair [47,[70][71][72], tissue [73,74] and exhaled breath condensate [75,76] have been used for the measurement of BUP, MTD and their metabo...…”

A Comprehensive Review on Developed Pharmaceutical Analysis Methods by Iranian Analysts in 2018

“…A similar work was reported by Baimani et al 109 for determination of methylprednisolone acetate after extraction with an allyl glycidyl ether/acrylic acid grafted on modified magnetite nanoparticles with functionalized dendrimer conjugated β-CD (AA@MNPs-D/β-CD) from spiked plasma and urine samples (see Figure 6). Similar works were performed for simultaneous extraction of morphine and codeine in the serum and blood samples after extraction by using magnetite (Fe 3 O 4 )/rGO/silver nano-composite (Ag NC) (with reported level of 0.610 -1.075 µg L -1 for morphine and 0.746 -1.124 µg L -1 for codeine in blood samples of addicted person to opium), 110 for determination of baclofen in spiked urine samples after extraction with superparamagnetic molecularly imprinted biopolymer (SMIBP), 111 for simultaneous determination of dasatinib, erlotinib, and nilotinib in spiked plasma, serum and urine samples after extraction by using bio-inspired magnetic sorbent doped melamine-phytate supermolecular aggregate (Fe 3 O 4 / MPA) applied for UA-DMSPE, 112 for determination of buprenorphine and norbuprenorphine in spiked plasma samples after extraction by poly (paraphenylenediamine)-modified Fe 3 O 4 nanoparticles (PpPDA/Fe 3 O 4 ), 113 for determination of rivaroxaban in spiked plasma and urine samples after extraction with a high generation thermo-sensitive dendrimer of magnetic nanoparticles/ poly(N-isopropylacrylamide)/ G10 4-amino-2,3-dimethyl-1phenyl-3-pyrazoline-5-one (MNPs/PNIPAAm/G10-ADMPhP) nanocomposite, 114 for determination of chlordiazepoxide in spiked urine samples after extraction with a magnetic MIP, 115 for determination of letrozole in spiked plasma and urine after extraction with magnetic nanoparticles (MNPs)/ polyethylene glycol (PEG)ylated dendrimer, 116 and for determination of amphetamine in spiked urine samples after extraction by using a magnetic block copolymer (poly ethylene glycolb-poly (N,N-dimethylaminoethylmethacrylate-co-maleic acid) (magnetic PEG-b-P(DMAEMA-co-MA)). 117…”