Highly Sensitive Strain Sensors Based on Molecules–Gold Nanoparticles Networks for High‐Resolution Human Pulse Analysis

Huang, Chang‐Bo; Yao, Yifan; Montes‐García, Verónica; Stoeckel, Marc‐Antoine; Holst, Miriam von; Ciesielski, Artur; Samorı́, Paolo

doi:10.1002/smll.202007593

Cited by 62 publications

(58 citation statements)

References 40 publications

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“…In resistance‐type strain sensors, GF can be calculated as: gε = Δ R / R 0 , where R 0 is the baseline resistance recorded under no stress, and Δ R / R 0 (Δ R / R 0 = ( R − R 0 )/ R 0 ) refers to the relative change of resistance under an applied strain (ε). [ 19 ]…”

Section: Wearable Strain/pressure Sensorsmentioning

confidence: 99%

Gold Nanomaterials‐Implemented Wearable Sensors for Healthcare Applications

Xianyu

2022

Adv Funct Materials

115

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Wearable sensors have drawn considerable interest for healthcare applications due to their low cost, flexibility, lightweight, and biocompatibility. Gold nanomaterials possess excellent properties such as high conductivity/ flexibility, facile surface functionalization, biocompatibility, wide electrochemical sensing window, and extraordinary optical response, making them excellent candidates for wearable sensors. By implementing gold nanomaterials such as gold nanoparticles (AuNPs) and gold nanowires (AuNWs), great efforts are devoted to fabricate wearable sensors with rational designs for healthcare applications. This review focuses on recent advances in gold nanomaterials-implemented wearable sensors, particularly the fabrication method, the working mechanism, and the performance of these wearable sensors in healthcare-related applications. Wearable sensors including strain/pressure sensors, humidity/gas sensors, electrochemical sensors, and colorimetric sensors are discussed and highlighted. Meanwhile, future prospects and challenges are also discussed on the development of gold nanomaterials-implemented wearable sensors.

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Section: Wearable Strain/pressure Sensorsmentioning

confidence: 99%

Gold Nanomaterials‐Implemented Wearable Sensors for Healthcare Applications

Xianyu

2022

Adv Funct Materials

115

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“…The low LOD and fast response toward N-gene by using the Nb 2 C-SH QDs-based aptasensor is mainly due to several aspects. (i) The strong self-assembling interaction between thiol bearing on the Nb 2 C-SH QDs and Au chip surface provides the outstanding stability of the aptasensor in the aqueous solution [70]. (ii) The strong bioaffinity between the aptamer and highly conjugated Nb 2 C-SH QDs via π-π * stacking, hydrogen bonds, and Van der Waal force facilitates the full coverage of the aptamer onto the Nb 2 C-SH QD-modified Au chip, leading to the high detection efficiency toward N-gene [71].…”

Section: Sensing Performance Of the Nb 2 C-sh Qd-based Aptasensor Toward N-genementioning

confidence: 99%

Surface plasmon resonance aptasensor based on niobium carbide MXene quantum dots for nucleocapsid of SARS-CoV-2 detection

et al. 2021

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A novel label-free surface plasmon resonance (SPR) aptasensor has been constructed for the detection of N-gene of SARS-CoV-2 by using thiol-modified niobium carbide MXene quantum dots (Nb 2 C-SH QDs) as the bioplatform for anchoring N-genetargeted aptamer. In the presence of SARS-CoV-2 N-gene, the immobilized aptamer strands changed their conformation to specifically bind with N-gene. It thus increased the contact area or enlarged the distance between aptamer and the SPR chip, resulting in a change of the SPR signal irradiated by the laser (He-Ne) with the wavelength (λ) of 633 nm. Nb 2 C QDs were derived from Nb 2 C MXene nanosheets via a solvothermal method, followed by functionalization with octadecanethiol through a self-assembling method. Subsequently, the gold chip for SPR measurements was modified with Nb 2 C-SH QDs via covalent binding of the Au-S bond also by self-assembling interaction. Nb 2 C-SH QDs not only resulted in high bioaffinity toward aptamer but also enhanced the SPR response. Thus, the Nb 2 C-SH QD-based SPR aptasensor had low limit of detection (LOD) of 4.9 pg mL −1 toward N-gene within the concentration range 0.05 to 100 ng mL −1 . The sensor also showed excellent selectivity in the presence of various respiratory viruses and proteins in human serum and high stability. Moreover, the Nb 2 C-SH QD-based SPR aptasensor displayed a vast practical application for the qualitative analysis of N-gene from different samples, including seawater, seafood, and human serum. Thus, this work can provide a deep insight into the construction of the aptasensor for detecting SARS-CoV-2 in complex environments.

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“…Gel materials in sensing can be generally classified into hydrogels formed by natural [ 28 , 29 , 30 , 31 ] or synthetic [ 16 , 32 , 33 ] polymers [ 22 , 25 ]. Gels coupled with other types of materials, e.g., gold nanoparticles [ 34 , 35 , 36 , 37 , 38 ] and quantum dots [ 39 , 40 ], can be distinguished as a hybrid group of hydrogel materials [ 31 ]. An interesting materials in the context of sensing applications are foldamers [ 41 , 42 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

Shaping Macromolecules for Sensing Applications—From Polymer Hydrogels to Foldamers

et al. 2022

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Sensors are tools for detecting, recognizing, and recording signals from the surrounding environment. They provide measurable information on chemical or physical changes, and thus are widely used in diagnosis, environment monitoring, food quality checks, or process control. Polymers are versatile materials that find a broad range of applications in sensory devices for the biomedical sector and beyond. Sensory materials are expected to exhibit a measurable change of properties in the presence of an analyte or a stimulus, characterized by high sensitivity and selectivity of the signal. Signal parameters can be tuned by material features connected with the restriction of macromolecule shape by crosslinking or folding. Gels are crosslinked, three-dimensional networks that can form cavities of different sizes and forms, which can be adapted to trap particular analytes. A higher level of structural control can be achieved by foldamers, which are macromolecules that can attain well-defined conformation in solution. By increasing control over the three-dimensional structure, we can improve the selectivity of polymer materials, which is one of the crucial requirements for sensors. Here, we discuss various examples of polymer gels and foldamer-based sensor systems. We have classified and described applied polymer materials and used sensing techniques. Finally, we deliberated the necessity and potential of further exploration of the field towards the increased selectivity of sensory devices.

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Highly Sensitive Strain Sensors Based on Molecules–Gold Nanoparticles Networks for High‐Resolution Human Pulse Analysis

Cited by 62 publications

References 40 publications

Gold Nanomaterials‐Implemented Wearable Sensors for Healthcare Applications

Gold Nanomaterials‐Implemented Wearable Sensors for Healthcare Applications

Surface plasmon resonance aptasensor based on niobium carbide MXene quantum dots for nucleocapsid of SARS-CoV-2 detection

Shaping Macromolecules for Sensing Applications—From Polymer Hydrogels to Foldamers

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