Highly sensitive voltammetric determination of lamotrigine at highly oriented pyrolytic graphite electrode

Saberi, Reyhaneh-Sadat; Shahrokhian, Saeed

doi:10.1016/j.bioelechem.2011.10.008

Cited by 25 publications

(16 citation statements)

References 25 publications

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“…Determination of LMT by adsorptive stripping voltammetry was carried out [ 118 ] by using an AgNP-modified carbon screen-printed electrode, and the LOD obtained was 372 nM after 200 s of accumulation. LMT also was determined [ 119 ] with a pyrolytic graphite electrode and obtained a LOD of 90 nM (after 100 s of accumulation), which makes this method more sensitive. It was observed that AgNP modification gave extremely low sensitivity for this class of drugs, thus this option can be explored deeply for future research which involves the analysis of LMT not only by voltammetry but even by UV–Vis, HPLC etc.…”

Section: Electrochemical Detection Of Drugs and Neurotransmitters Basmentioning

confidence: 99%

Nanomaterial-based electrochemical sensing of neurological drugs and neurotransmitters

et al. 2014

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Nanomaterial-modified detection systems represent a chief driver towards the adoption of electrochemical methods, since nanomaterials enable functional tunability, ability to self-assemble, and novel electrical, optical and catalytic properties that emerge at this scale. This results in tremendous gains in terms of sensitivity, selectivity and versatility. We review the electrochemical methods and mechanisms that may be applied to the detection of neurological drugs. We focus on understanding how specific nano-sized modifiers may be applied to influence the electron transfer event to result in gains in sensitivity, selectivity and versatility of the detection system. This critical review is structured on the basis of the Anatomical Therapeutic Chemical (ATC) Classification System, specifically ATC Code N (neurotransmitters). Specific sections are dedicated to the widely used electrodes based on the carbon materials, supporting electrolytes, and on electrochemical detection paradigms for neurological drugs and neurotransmitters within the groups referred to as ATC codes N01 to N07. We finally discuss emerging trends and future challenges such as the development of strategies for simultaneous detection of multiple targets with high spatial and temporal resolutions, the integration of microfluidic strategies for selective and localized analyte pre-concentration, the real-time monitoring of neurotransmitter secretions from active cell cultures under electro- and chemotactic cues, aptamer-based biosensors, and the miniaturization of the sensing system for detection in small sample volumes and for enabling cost savings due to manufacturing scale-up. The Electronic Supporting Material (ESM) includes review articles dealing with the review topic in last 40 years, as well as key properties of the analytes, viz., pKa values, half-life of drugs and their electrochemical mechanisms. The ESM also defines analytical figures of merit of the drugs and neurotransmitters. The article contains 198 references in the main manuscript and 207 references in the Electronic Supporting Material.FigureᅟElectronic supplementary materialThe online version of this article (doi:10.1007/s00604-014-1308-4) contains supplementary material, which is available to authorized users.

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Section: Electrochemical Detection Of Drugs and Neurotransmitters Basmentioning

confidence: 99%

Nanomaterial-based electrochemical sensing of neurological drugs and neurotransmitters

et al. 2014

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“…LAM is a second-generation, poor water-soluble antiepileptic drug from the phenyltriazine and the BSC II class with a relatively good side effect spectrum [36]. It is used for the treatment of epilepsy, Lennox-Gastaut syndrome and bipolar disease in monotherapy or as an adjuvant [37][38][39]. It is absorbed from the GI tract with no significant First Pass Effect (FPE).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Absorption of Nanosized lamotrigine Containing Nasal Powder via the Nasal Cavity

et al. 2020

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Nasal drug delivery has become a popular research field in the last years. This is not surprising since the nose possesses unique anatomical and physical properties. Via the nasal mucosa local, systemic, and directly central nerve systemic (CNS) effect is achievable. Powders have favorable physicochemical properties over liquid formulations. Lamotrigine (LAM) is an antiepileptic agent with a relatively mild side effect spectrum, but only available in tablet form on market. Reducing the particle size to the nano range can affect the bioavailability of pharmaceutical products. The aim of this article was to continue the work started, compare the in vitro properties of a nanonized lamotrigine containing nasal powder (nanoLAMpowder) and its physical mixture (PM) that were prepared by dry milling. Moreover, to study their trans-epithelial absorption to reach the blood and target the brain by axonal transport. Due to the dry milling technique, the particle size of LAM, their surface and also their structure changed that led to higher in vitro dissolution and permeability rate. The results of the in vivo tests showed that the axonal transport of the drug was assumable by both intranasal formulations because the drug was present in the brain within a really short time, but the LAM from the nanoLAMpowder liberated even faster.

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“…5 Lamotrigine and its metabolites in pharmaceutical products and biological uids typically have been monitored by gas chromatography with a nitrogen phosphorus detector, 6 radioimmuno assay, 7 high performance liquid chromatography (HPLC), [8][9][10][11][12][13][14][15][16] liquid chromatography tandem mass spectrometry, 17 capillary electrophoresis, 18,19 immunouorometric assay, 20 molecular imprinting technology, 21,22 and voltammetric determination. [23][24][25][26] Owing to the dangerous side effect of LTG, the pharmaceutical quantity control of LTG is vital. So, development of a sensitive and versatile analytical method is needed for its determination.…”

Section: Introductionmentioning

confidence: 99%

Application of magnetic lamotrigine-imprinted polymer nanoparticles as an electrochemical sensor for trace determination of lamotrigine in biological samples

Bojdi

Behbahani²,

Hesam

et al. 2016

RSC Adv.

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Highly sensitive voltammetric determination of lamotrigine at highly oriented pyrolytic graphite electrode

Cited by 25 publications

References 25 publications

Nanomaterial-based electrochemical sensing of neurological drugs and neurotransmitters

Nanomaterial-based electrochemical sensing of neurological drugs and neurotransmitters

Investigation of the Absorption of Nanosized lamotrigine Containing Nasal Powder via the Nasal Cavity

Application of magnetic lamotrigine-imprinted polymer nanoparticles as an electrochemical sensor for trace determination of lamotrigine in biological samples

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