Highly stable high performance liquid chromatography stationary phase based on direct chemical modification of organic bridges in hybrid silica

Yu, Hui; Jia, Cunyu; Wu, Haibo; Song, Guangjun; Jin, Yu; Ke, Yanxiong; Liang, Xinmiao

doi:10.1016/j.chroma.2012.05.062

Cited by 14 publications

(5 citation statements)

References 30 publications

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“…Liang and coworkers (96) improved phenylene-bridged microspheres with particle sizes of 3.0-3.5 μm and a pore size of 85 Å for RPLC, showing relatively high column efficiency (H min = 10 μm), a large retention factor, and significant enhancement in column stability at pH 10. The 1,4dimethoxybenzene-bridged hybrid mesoporous spheres were also synthesized by condensation of 1,4-dimethoxy-2,5-bis(triethoxysilyl)benzene using dodecylamine and cetyltrimethylammonium bromide as cotemplates, with a high stability between pH 0.95 and pH 11 (97).…”

Section: Periodic Mesoporous Organosilicasmentioning

confidence: 99%

Well-Defined Materials for High-Performance Chromatographic Separation

Liang

Zhang

2019

Annual Rev. Anal. Chem.

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Chromatographic separation has been widely applied in various fields, such as chemical engineering, precision medicine, energy, and biology. Because chromatographic separation is based on differential partitioning between the mobile phase and stationary phase and affected by band dispersion and mass transfer resistance from these two phases, the materials used as the stationary phase play a decisive role in separation performance. In this review, we discuss the design of separation materials to achieve the separation with high efficiency and high resolution and highlight the well-defined materials with uniform pore structure and unique properties. The achievements, recent developments, challenges, and future trends of such materials are discussed. Furthermore, the surface functionalization of separation ma-terials for further improvement of separation performance is reviewed. Finally, future research directions and the challenges of chromatographic separation are presented.

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Section: Periodic Mesoporous Organosilicasmentioning

confidence: 99%

Well-Defined Materials for High-Performance Chromatographic Separation

Liang

Zhang

2019

Annual Rev. Anal. Chem.

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“…In recent years, numerous improvements have been made on stationary phases for HPLC to deal with problems caused by either the silica supports or the bonded phases . However, currently available stationary phases still have two major limits.…”

Section: Introductionmentioning

confidence: 99%

Dicationic imidazolium ionic liquid modified silica as a novel reversed-phase/anion-exchange mixed-mode stationary phase for high-performance liquid chromatography

et al. 2014

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A dicationic imidazolium ionic liquid modified silica stationary phase was prepared and evaluated by reversed-phase/anion-exchange mixed-mode chromatography. Model compounds (polycyclic aromatic hydrocarbons and anilines) were separated well on the column by reversed-phase chromatography; inorganic anions (bromate, bromide, nitrate, iodide, and thiocyanate), and organic anions (p-aminobenzoic acid, p-anilinesulfonic acid, sodium benzoate, pathalic acid, and salicylic acid) were also separated individually by anion-exchange chromatography. Based on the multiple sites of the stationary phase, the column could separate 14 solutes containing the above series of analytes in one run. The dicationic imidazolium ionic liquid modified silica can interact with hydrophobic analytes by the hydrophobic C6 chain; it can enhance selectivity to aromatic compounds by imidazolium groups; and it also provided anion-exchange and electrostatic interactions with ionic solutes. Compared with a monocationic ionic liquid functionalized stationary phase, the new stationary phase represented enhanced selectivity owing to more interaction sites.

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“…Furthermore, nonspecific adsorption of bio‐macromolecules due to surface silanol groups has further decreased enthusiasm for the use of silica materials for their separation. Recently, researchers have improved the chemical stability of silica materials (broadened the pH range from 1 to 12) and reduced the nonspecific adsorption of analytes . However, the required lengthy modification procedures and reservations concerning long‐term stability of these modified stationary phases continue to dampen enthusiasm for these columns.…”

Section: Introductionmentioning

confidence: 99%

Organic monoliths for high‐performance reversed‐phase liquid chromatography

Liu

Aggarwal

Lawson

et al. 2013

J of Separation Science

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RPLC is the most common mode of LC. It is widely used for separations of both small and large molecules. Monolithic columns, which are currently under intensive study by many groups, have the potential of becoming attractive alternatives to particle-packed columns. They are generally easier and faster to fabricate, and they demonstrate a lower pressure drop, less nonspecific adsorption, and richer chemistry (in the case of organic polymer monoliths) for providing broad selectivity. Silica monoliths, as is also true for columns packed with silica particles, are best applied to small-molecule separations. Organic polymer monoliths, on the other hand, have shown advantages for large-molecule separations. Recently, improvements in organic monoliths have led to efficiencies for small molecules that are approaching and even surpassing 100,000 plates/m. While this performance is still far short of what is currently available using modern small particles and silica monoliths in RPLC, steady progress is being made. This review describes recent developments in the synthesis and performance of organic polymer RPLC monoliths, and identifies areas where additional work is needed to significantly improve their performance for both small- and large-molecule separations.

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Highly stable high performance liquid chromatography stationary phase based on direct chemical modification of organic bridges in hybrid silica

Cited by 14 publications

References 30 publications

Well-Defined Materials for High-Performance Chromatographic Separation

Well-Defined Materials for High-Performance Chromatographic Separation

Dicationic imidazolium ionic liquid modified silica as a novel reversed-phase/anion-exchange mixed-mode stationary phase for high-performance liquid chromatography

Organic monoliths for high‐performance reversed‐phase liquid chromatography

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