“…[256] As shown in Scheme 173, using oxindole derivatives 655 and wnitro-substituted alkenes 656 as the substrates andt he cyclohexanediamine-derived thiourea 581 as the catalyst, the domino reaction producede ither diastereomers 657a or 657b depending on the configurationo f the nitroalkenes( 656), with (E)-configured 656a giving diastereomers 657a,a nd (Z)-configured 656b giving diastereomers 657b.B oth diastereomers were obtained as single diastereomersi nm oderate to good yields ande xcellent stereoselectivities.S imilar reactions between 655 and 658 catalyzed by the quinidinederivedt hiourea 660 gave the corresponding spirocyclopentane oxindole derivatives 659a or 659b in moderate to good yields and excellent stereoselectivities, again depending on the configuration of the nitroalkenes 658 (Scheme 173). [256] Wang and co-workers realized an asymmetric domino Michael/cyclization/tautomerization reaction between isatylidenemalononitriles 615 and a,a-dicyanoalkenes 662 or 535,u sing the quinine-derived thiourea 664 as the catalyst (Scheme174). [257] Ther eactions offered spirooxindoled erivatives 661 and 663 in good enantioselectivities, respectively.H owever, in the case of 661,t he diastereoselectivities obtained were generally low.Aone-pot three-componentv ariant of this domino reactioni nvolving N-acetylisatin (302a), malononitrile (407a), and 662 under the conditions optimized for the two-component reaction produced 661 with as atisfactory yield and stereoselectivity.…”