Highly stereoselective α-glycosylation with GalN₃donors enabled collective synthesis of mucin-related tumor associated carbohydrate antigens

Abstract

Mucin-related tumor-associated carbohydrate antigens (TACA) are important and interesting targets for cancer vaccine therapy. However, the efficient access to a library of mucin-related TACA remains a challenging task. One of...

Total Synthesis of Nona-decasaccharide Motif from Ganoderma sinense Polysaccharide Enabled by Modular and One-Pot Stereoselective Glycosylation Strategy

“…Chemical synthesis provides a reliable means of solving this accessibility issue. Nonetheless, because of stereoselectivity and regioselectivity issues , during glycans assembly, glycans synthesis remains tedious and time-consuming. While the milestone synthesis of 92-mer arabinogalactan and 101-mer mannose-capped lipoarabinomannan from Mycobacterium tuberculosis , 100-mer and 151-mer mannans, 128-mer O-antigen from Bacteroides vulgatus , 140-mer arabinogalactan from Panax notoginseng , and 1080-mer arabinan has been achieved in recent years, efficient synthesis of long, branched, and complex glycans containing many 1,2- cis -glycosidic linkages over 10-mer remains a challenging task …”