Highly Stretchable DNA/Clay Hydrogels with Self-Healing Ability

Uzumcu, Ahmet T.; Güney, Orhan; Okay, Oğuz

doi:10.1021/acsami.8b00168

Cited by 51 publications

(36 citation statements)

References 56 publications

(108 reference statements)

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“…Hydrogels can be divided into physical hydrogels and chemical hydrogels based on the crosslinking points. Physical crosslinking points, also called as dynamic noncovalent bonds, include hydrogen bonds, metal coordination bonds, hydrophobic interaction, electrostatic ionic interaction, π‐π stacking, and host‐guest inclusion . Chemical crosslinking points include dynamic covalent bonds, such as imine bonds, acylhydrazone bonds, disulfide bonds, boron ester bonds, and nondynamic covalent bonds that cannot be reformed after breakage.…”

Section: Introductionmentioning

confidence: 99%

Self‐healing and conductivity of chitosan‐based hydrogels formed by the migration of ferric ions

Cheng

Bao

et al. 2019

J of Applied Polymer Sci

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The currently reported self-healing hydrogels have problems of low mechanical strength, single performance, and poor self-healing efficiency, which greatly limit their applications. Here, through adding N-carboxyethyl chitosan to acrylic-Fe 3+ system, the self-healing physically crosslinked hydrogels were prepared via in situ free radical polymerization, which have excellent self-healing ability and mechanical properties. The maximum tensile strength and elongation at break of the hydrogels can reach up to 280 KPa and 1900%, respectively. Owing to the reversibility of coordination, self-healing efficiency of the hydrogels can reach 98% in 2.5 h. Moreover, the hydrogels also have good conductivity due to the migration of Fe 3+ . This strategy can broaden the applications of chitosan-based self-healing hydrogels.Since the metal coordination has multiple coordination points, it can form hydrogels with high strength and self-healing ability. Metal ions, like Fe 3+ , Zn 2+ , Cu 2+ , can form strong coordination with some groups, such as OH, COOH, NH 2. 32-34 The ionicAdditional Supporting Information may be found in the online version of this article.

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Section: Introductionmentioning

confidence: 99%

Self‐healing and conductivity of chitosan‐based hydrogels formed by the migration of ferric ions

Cheng

Bao

et al. 2019

J of Applied Polymer Sci

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“…Moreover, the Si-O stretching vibration peak of laponite at 1000 cm −1 is observed in the spectrum of the PD3L4 NCH, as expected 36 . The shift of the O-H stretching vibration from 3470 cm −1 for the PD3 hydrogel to 3500 cm −1 for the PD3L4 NCH and 3595 cm −1 for the PD3L4F2 MR_NCH after adding laponite nanoparticles demonstrates the intermolecular interactions between the laponite nanoparticles and PDMAAm chains 37 . For pure Fe 3 O 4 nanoparticles, the characteristic peak at 607 cm −1 is assigned to the stretching vibration of the Fe–O bond in the Fe 3 O 4 crystalline lattice, and the peak at 3450 cm −1 corresponds to the O-H stretching vibration of water molecules around the metallic particles.…”

Section: Resultsmentioning

confidence: 92%

Highly Tough, Biocompatible, and Magneto-Responsive Fe3O4/Laponite/PDMAAm Nanocomposite Hydrogels

Lee

Han

Jang

et al. 2019

Sci Rep

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Magneto-responsive hydrogels (MRHs) have attracted considerable attention in various applications owing to their smart response to an externally applied magnetic field. However, their practical uses in biomedical fields are limited by their weak mechanical properties and possible toxicity to the human body. In this study, tough, biocompatible, and magneto-responsive nanocomposite hydrogels (MR_NCHs) were developed by the in-situ free-radical polymerization of N, N-dimethylacrylamide (DMAAm) and laponite and Fe3O4 nanoparticles. The effects of the concentrations of DMAAm, water, and laponite and Fe3O4 nanoparticles in the pre-gel solutions or mixtures on the viscoelastic and mechanical properties of the corresponding hydrogels were examined by performing rheological and tensile tests, through which the mixture composition producing the best MR_NCH system was optimized. The effects were also explained by the possible network structures of the MR_NCHs. Moreover, the morphology, chemical structure, and thermal and mechanical properties of the MR_NCHs were analyzed, while comparing with those of the poly(DMAAm) (PDMAAm) hydrogels and laponite/PDMAAm NCHs. The obtained optimal MR_NCH exhibited noticeable magnetorheological (MR) behavior, excellent mechanical properties, and good biocompatibility. This study demonstrates how to optimize the best Fe3O4/laponite/PDMAAm MR_NCH system and its potential as a soft actuator for the pharmaceutical and biomedical applications.

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“…Dynamic covalent bonds include imine bond ( Qu et al, 2017 ; Yan et al, 2017 ; Chen H. et al, 2018 ; Chen et al, 2019e ; Khan et al, 2018 ; Wei and Gerecht, 2018 ; Zhang et al, 2018 ; Guo B. et al, 2019 ; Jiang F. et al, 2019 ; Li Q. et al, 2019 ; Qian et al, 2019 ; Wang et al, 2019b ; Wang W. et al, 2019 ; Zhou et al, 2019 ), Diels–Alder (DA) reaction ( Oehlenschlaeger et al, 2014 ), boronate-diol complexation ( Hong et al, 2018 ; Pan et al, 2018 ; Smithmyer et al, 2018 ; Zhi et al, 2018 ; Han et al, 2019 ), acylhydrazone bond ( Yang et al, 2017 ; Shen et al, 2019 ; Sun C. et al, 2019 ), dynamic disulfide bond ( Song L. et al, 2019 ), and dynamic metal oordination ( Shao et al, 2018 ; Chen et al, 2019a ; Qin et al, 2019 ). Physical non-covalent interactions include hydrogen bonding ( Fan et al, 2018 ; Uzumcu et al, 2018 ; Cao et al, 2019 ; Chen et al, 2019c ; Hu et al, 2019 ; Huang et al, 2019 ; Kuddushi et al, 2019 ; Li R. et al, 2019 ; Liao et al, 2019 ; Su et al, 2019 ; Wang L. et al, 2019 ), hydrophobic interaction ( Liu P. et al, 2019 ), host-guest interaction ( Deng Z. et al, 2018 ; Li Q. et al, 2018 ; Liu L. et al, 2019 ; Wang W. et al, 2019 ), and ionic interaction ( Ma et al, 2018 ; Wang Y. et al, 2018 ; Becher et al, 2019 ). Some intrinsic type self-healing hydrogels even have several kinds of networks, containing either one type or several types of mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Advances in Synthesis and Applications of Self-Healing Hydrogels

Fan

Qian

et al. 2020

Front. Bioeng. Biotechnol.

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Background: Hydrogels, a type of three-dimensional (3-D) crosslinked network of polymers containing a high water concentration, have been receiving increasing attention in recent years. Self-healing hydrogels, which can return to their original structure and function after physical damage, are especially attractive. Some selfhealable hydrogels have several kinds of properties such as injectability, adhesiveness, and conductivity, which enable them to be used in the manufacturing of drug/cell delivery vehicles, glues, electronic devices, and so on. Main Body: This review will focus on the synthesis and applications of self-healing hydrogels. Their repair mechanisms and potential applications in pharmaceutical, biomedical, and other areas will be introduced. Conclusion: Self-healing hydrogels are used in various fields because of their ability to recover. The prospect of self-healing hydrogels is promising, and they may be further developed for various applications.

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Highly Stretchable DNA/Clay Hydrogels with Self-Healing Ability

Cited by 51 publications

References 56 publications

Self‐healing and conductivity of chitosan‐based hydrogels formed by the migration of ferric ions

Self‐healing and conductivity of chitosan‐based hydrogels formed by the migration of ferric ions

Highly Tough, Biocompatible, and Magneto-Responsive Fe3O4/Laponite/PDMAAm Nanocomposite Hydrogels

Advances in Synthesis and Applications of Self-Healing Hydrogels

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