Highly swellable ultrathin poly(4-vinylpyridine) multilayer hydrogels with pH-triggered surface wettability

Wang, Yun; Kozlovskaya, Veronika; Arcibal, Imee G.; Cropek, Donald M.; Kharlampieva, Eugenia

doi:10.1039/c3sm51496j

Cited by 35 publications

(50 citation statements)

References 70 publications

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“…Finally, we fabricated spherical and cubical (silk/PVCL) LbL capsules of regulated permeability and enzymatic degradation. 51,61,62 This result is in good agreement with prior work on polyelectrolyte multilayers As previously reported, silk biodegradation occurs because of the enzyme-induced hydrolysis of ester bonds followed by silk mass loss. Accounting for all-aqueous fabrication and the biocompatibility of both polymers these biodegradable materials provide novel platforms for delivery systems and medical devices.…”

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confidence: 91%

Tuning assembly and enzymatic degradation of silk/poly(N-vinylcaprolactam) multilayers via molecular weight and hydrophobicity

et al. 2015

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We report on enzymatically degradable nanothin coatings obtained by layer-by-layer (LbL) assembly of silk fibroin with poly(N-vinylcaprolactam) (PVCL) via hydrogen bonding and hydrophobic interactions. We found that both silk β-sheet content, controlled through dipping and spin-assisted LbL, and PVCL molecular weight regulate film thickness, microstructure, pH-stability, and biodegradability with a nanoscale precision. Thickness of (silk/PVCL) films increased with increase in PVCL molecular weight and decrease in deposition pH. The impact of assembly pH on film growth was more dramatic for dipped films. These systems show a significant rise in thickness with increase in PVCL molecular weight at pH < 5 but become independent on polymer chain length at pH ≥ 5. We also found that spin-assisted films exhibited a greater stability at elevated pH and against enzymatic degradation as compared to their dipped counterparts. For both film types, the pH and enzymatic stability was improved with increasing PVCL length and β-sheet content, indicating enhanced hydrophobic and hydrogen-bonded interactions between PVCL and silk. Finally, we fabricated spherical and cubical (silk/PVCL) LbL capsules of regulated permeability and enzymatic degradation. Our approach gives a unique opportunity to tune thickness, morphology, structure, and biodegradability rate of silk films and capsules by varying silk secondary structure and PVCL length. Accounting for all-aqueous fabrication and the biocompatibility of both polymers these biodegradable materials provide novel platforms for delivery systems and medical devices.

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confidence: 91%

Tuning assembly and enzymatic degradation of silk/poly(N-vinylcaprolactam) multilayers via molecular weight and hydrophobicity

et al. 2015

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“…In contrast to traditional hydrogel coatings, LbL-derived networks can be deposited on substrates of various shapes and morphology [42][43][44][45][46][47][48]. These nanothin hydrogels are capable of fast and dramatic volume change and can host various types of molecules and ions [49][50][51][52][53][54]. Sukhishvili et al reported on the ability of (PMAA) networks to reversibly absorb large amount of proteins and peptides [40,55].…”

Section: Introductionmentioning

confidence: 99%

“…Sukhishvili et al reported on the ability of (PMAA) networks to reversibly absorb large amount of proteins and peptides [40,55]. We have recently shown that poly(4-vinylpyridine) (PVP) nanothin hydrogels produced from PVP/poly(methacrylic acid) (PVP/PMAA) multilayers exhibit a fast (within seconds) and drastic 10-fold reversible swelling when pH is switched from neutral to acidic [49].…”

Section: Introductionmentioning

confidence: 99%

Nanostructured highly-swollen hydrogels: Complexation with amino acids through copper (II) ions

Zavgorodnya

Kozlovskaya

Kharlampieva

2015

Polymer

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We report on the complexation of highly swollen poly(methacrylic acid) (PMAA) nanothin hydrogel films with copper (II) ions and the stability of these (PMAA)-Cu 2+ complexes in amino acid solutions. These networks are produced by selective cross-linking of PMAA with adipic acid dihydrazide (AAD) and ethylenediamine (EDA) in hydrogen-bonded spin-assisted layer-bylayer films. The swelling of the hydrogels at higher pH values is significantly suppressed after introducing copper (II) ions and can be restored by treatment with amino acid solutions including serine, threonine, arginine, histidine and glutamine. The hydrogel swelling recovery is controlled by Cu 2+ removal from the hydrogel which is regulated by the strength of [(PMAA) n-Cu 2+ ] complex bonding and is dependent on the amino acid type, concentration and the hydrogel"s cross-linker. The use of AAD as a cross-linker allows for selective binding and recognition of arginine among other amino acids. The special affinity of the [(PMAA) 16-AAD-Cu 2+ ] hydrogel complex to arginine is due to the formation of ternary (hydrogel-copper-arginine) complexes stabilized by electrostatic interactions between the carboxylic groups of PMAA and the guanidinium side group of arginine. Our study provides new aspects of competing interactions between polyelectrolyte networks, metal ions, and amino-acids and opens prospects for developing novel analyte-responsive biosensors.

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“…This response resulted from the ionization of carboxyl groups, which induced swelling of the P(MAA‐ co ‐EGDA) hydrogel. A similar strategy was used to fabricate a pH‐responsive surface by coating a poly(4‐vinyl pyridine) (PVP) hydrogel thin film on a silicon substrate . The PVP hydrogel showed severe and reversible tenfold swelling when switching the pH from neutral to acidic, leading to the sharp transition of surface wettability from the hydrophobic (CA: 70°) to the hydrophilic state (CA: 20°).…”

Section: Engineering Bioinspired Gel Surfaces With Superwettabilitymentioning

confidence: 99%

Recent Advances in Bioinspired Gel Surfaces with Superwettability and Special Adhesion

Zhang

Zhao

et al. 2019

Advanced Science

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Engineering surface wettability is of great importance in academic research and practical applications. The exploration of hydrogel‐based natural surfaces with superior properties has revealed new design principles of surface superwettability. Gels are composed of a cross‐linked polymer network that traps numerous solvents through weak interactions. The natural fluidity of the trapped solvents confers the liquid‐like property to gel surfaces, making them significantly different from solid surfaces. Bioinspired gel surfaces have shown promising applications in diverse fields. This work aims to summarize the fundamental understanding and emerging applications of bioinspired gel surfaces with superwettability and special adhesion. First, several typical hydrogel‐based natural surfaces with superwettability and special adhesion are briefly introduced, followed by highlighting the unique properties and design principles of gel‐based surfaces. Then, the superwettability and emerging applications of bioinspired gel surfaces, including liquid/liquid separation, antiadhesion of organisms and solids, and fabrication of thin polymer films, are presented in detail. Finally, an outlook on the future development of these novel gel surfaces is also provided.

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Highly swellable ultrathin poly(4-vinylpyridine) multilayer hydrogels with pH-triggered surface wettability

Cited by 35 publications

References 70 publications

Tuning assembly and enzymatic degradation of silk/poly(N-vinylcaprolactam) multilayers via molecular weight and hydrophobicity

Tuning assembly and enzymatic degradation of silk/poly(N-vinylcaprolactam) multilayers via molecular weight and hydrophobicity

Nanostructured highly-swollen hydrogels: Complexation with amino acids through copper (II) ions

Recent Advances in Bioinspired Gel Surfaces with Superwettability and Special Adhesion

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