Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing wearable strain sensor

Zhang, Jing; Chen, Lingdong; Shen, Biao; Wang, Yirou; Peng, Pai; Tang, Feiyu; Feng, Jie

doi:10.1016/j.msec.2020.111298

Cited by 91 publications

(53 citation statements)

References 58 publications

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“…[96] On a similar vein, Zhang et al proposed a DN hydrogel composed of a chitosan (CS) network and poly(sulfobetaine-co-acrylic acid) (p(SBMA-co-AAc)) copolymer network. [97] The first network was formed thanks to electrostatic interactions between CS and citrate ions, while of p(SBMA-co-AAc) network was formed by ionic interactions between zwitterionic moieties and hydrogen bonding between carboxyl groups. This DN hydrogel, besides having a higher resistance under deformation, high transparency, self-healing properties, and good electrical conductivity, also showed shear thinning properties, demonstrating to be a promising material system for 3D printing applications.…”

Section: Double Network Hydrogelsmentioning

confidence: 99%

“…This DN hydrogel, besides having a higher resistance under deformation, high transparency, self-healing properties, and good electrical conductivity, also showed shear thinning properties, demonstrating to be a promising material system for 3D printing applications. [97] Clearly, DNs and IPNs can create dynamic networks, which invoke self-assembly in living systems, thanks to non-covalent interactions, but thanks also to covalent interactions they possess better mechanical properties than classic hydrogels. [98] Although their cytocompatibility remains their most attractive feature for TE applications, their final mechanical properties still fall short of the ones observed in many (human) living tissues.…”

Section: Double Network Hydrogelsmentioning

confidence: 99%

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The Importance of Interfaces in Multi‐Material Biofabricated Tissue Structures

Viola

Piluso

Groll

et al. 2021

Adv Healthcare Materials

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Biofabrication exploits additive manufacturing techniques for creating 3Dstructures with a precise geometry that aim to mimic a physiological cellular environment and to develop the growth of native tissues. The most recent approaches of 3D biofabrication integrate multiple technologies into a single biofabrication platform combining different materials within different length scales to achieve improved construct functionality. However, the importance of interfaces between the different material phases, has not been adequately explored. This is known to determine material's interaction and ultimately mechanical and biological performance of biofabricated parts. In this review, this gap is bridged by critically examining the interface between different material phases in (bio)fabricated structures, with a particular focus on how interfacial interactions can compromise or define the mechanical (and biological) properties of the engineered structures. It is believed that the importance of interfacial properties between the different constituents of a composite material, deserves particular attention in its role in modulating the final characteristics of 3D tissue-like structures.

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Section: Double Network Hydrogelsmentioning

confidence: 99%

Section: Double Network Hydrogelsmentioning

confidence: 99%

The Importance of Interfaces in Multi‐Material Biofabricated Tissue Structures

Viola

Piluso

Groll

et al. 2021

Adv Healthcare Materials

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“…Zhang et al used the phenomenon of electrostatic interaction and hydrogen bonding to physically crosslink poly (sulfobetaine-co-acrylic acid)/chitosan–citrate to form a double network hydrogel. The hydrogel thus prepared showed high transparency, excellent self-healing properties (as high as 95.4%), good electrical conductivity (conductivity 0.11 S/m), and reasonable sensitivity [ 75 ].…”

Section: Three-dimensional Printing In Development Of Nanomedicinementioning

confidence: 99%

3D Printing in Development of Nanomedicines

et al. 2021

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Three-dimensional (3D) printing is gaining numerous advances in manufacturing approaches both at macro- and nanoscales. Three-dimensional printing is being explored for various biomedical applications and fabrication of nanomedicines using additive manufacturing techniques, and shows promising potential in fulfilling the need for patient-centric personalized treatment. Initial reports attributed this to availability of novel natural biomaterials and precisely engineered polymeric materials, which could be fabricated into exclusive 3D printed nanomaterials for various biomedical applications as nanomedicines. Nanomedicine is defined as the application of nanotechnology in designing nanomaterials for different medicinal applications, including diagnosis, treatment, monitoring, prevention, and control of diseases. Nanomedicine is also showing great impact in the design and development of precision medicine. In contrast to the “one-size-fits-all” criterion of the conventional medicine system, personalized or precision medicines consider the differences in various traits, including pharmacokinetics and genetics of different patients, which have shown improved results over conventional treatment. In the last few years, much literature has been published on the application of 3D printing for the fabrication of nanomedicine. This article deals with progress made in the development and design of tailor-made nanomedicine using 3D printing technology.

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“…Zhang et al prepared a CS/P(SBMA-co-AAc) hydrogel based on dual physical crosslinking. [196] After injected in the sodium citrate solution, hydrogels were further crosslinked by chitosancitrate ions coordination. Meanwhile, citrate ions played a role in providing conductibility.…”

Section: Strain Sensorsmentioning

confidence: 99%

Recent Advances in Injectable Dual Crosslinking Hydrogels for Biomedical Applications

Chu

Nie

et al. 2021

Macromolecular Bioscience

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Injectable dual crosslinking hydrogels hold great promise to improve therapeutic efficacy in minimally invasive surgery. Compared with prefabricated hydrogels, injectable hydrogels can be implanted more accurately into deeply enclosed sites and repair irregularly shaped lesions, showing great applicable potential. Here, the current fabrication considerations of injectable dual crosslinking hydrogels are reviewed. Besides, the progress of the hydrogels used in corresponding applications and emerging challenges are discussed, with detailed emphasis in the fields of bone and cartilage regeneration, wound dressings, sensors and other less mentioned applications for their more hopeful employments in clinic. It is envisioned that the further development of the injectable dual crosslinking hydrogels will catalyze their innovation and transformation in the biomedical field.

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Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing wearable strain sensor

Cited by 91 publications

References 58 publications

The Importance of Interfaces in Multi‐Material Biofabricated Tissue Structures

The Importance of Interfaces in Multi‐Material Biofabricated Tissue Structures

3D Printing in Development of Nanomedicines

Recent Advances in Injectable Dual Crosslinking Hydrogels for Biomedical Applications

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