Highly tumor-specific DNA nanostructures discovered by in vivo screening of a nucleic acid cage library and their applications in tumor-targeted drug delivery

Kim, Kyoung-Ran; Kang, Seong Jae; Lee, A‐Young; Hwang, Dohyeon; Park, Miri; Park, Haedong; Kim, Sanghee; Hur, Kahyun; Chung, Hak Suk; Mao, Chengde; Ahn, Dae‐Ro

doi:10.1016/j.biomaterials.2018.12.026

Cited by 51 publications

(32 citation statements)

References 43 publications

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“…They revealed that triangle-shaped origami accumulated at the tumor site and reached peak levels at 6 h and maintained high levels for 24 h after intravenous administration. Kim et al built a library of wireframe DNA objects of various backbones for in vivo screening (Kim et al, 2019). According to their results, cages with backbone modifications had better tumor accumulation.…”

Section: Passive Delivery To Tumorsmentioning

confidence: 99%

Rationally Designed DNA Nanostructures for Drug Delivery

Xia

Wang

2020

Front. Chem.

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DNA is an excellent biological material that has received growing attention in the field of nanotechnology due to its unique capability for precisely engineering materials via sequence specific interactions. Self-assembled DNA nanostructures of prescribed physicochemical properties have demonstrated potent drug delivery efficiency in vitro and in vivo. By using various conjugation techniques, DNA nanostructures may be precisely integrated with a large diversity of functional moieties, such as targeting ligands, proteins, and inorganic nanoparticles, to enrich their functionalities and to enhance their performance. In this review, we start with introducing strategies on constructing DNA nanostructures. We then summarize the biological barriers ahead of drug delivery using DNA nanostructures, followed by introducing existing rational solutions to overcome these biological barriers. Lastly, we discuss challenges and opportunities for DNA nanostructures toward real applications in clinical settings.

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Section: Passive Delivery To Tumorsmentioning

confidence: 99%

Rationally Designed DNA Nanostructures for Drug Delivery

Xia

Wang

2020

Front. Chem.

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“…Furthermore, the fluorescence emission of the Nile Red molecules, which was drastically decreased by injecting two strands that destroy the hydrophobic cores of its dendritic DNA amphiphile, was confirmed. Several types of cage-like DNA nanostructures have been introduced as carriers for metals or large-size proteins [27][28][29].…”

Section: Metals and Proteinsmentioning

confidence: 99%

Structural DNA nanotechnology towards therapeutic applications

Yoon

Lee

Kim

2021

J. Korean Phys. Soc.

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A DNA molecule is a genetic material composed of a double helix. Inspired by its unique characteristics, scientists have exploited DNA strands for engineering nanostructures. The development of DNA origami, which has enabled the customized production of DNA nanostructures, has been of crucial significance. Ever since, various DNA nanostructures have been proposed, promising the effective treatment of diverse diseases. In particular, we introduce the key strategies and technological advances of a range of DNA nanostructures, including DNA-based drug delivery systems and DNA nanorobots.

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“…Very recently, Green and colleagues critically summarized the factors that need to be standardized, to assist in easier translation from laboratory conditions into clinic [45]. In another effort, Kim and colleagues developed tumor-specific drug carriers by screening a library of self-assembled nucleic acid cages in tumor-bearing mice [50]. Interestingly, the authors concluded that tumor specificity was closely related with serum stability, cancer cell uptake efficiency and macrophage evasion rate, and suggested that the library-based strategy can be an efficient way to develop anti-cancer nanomedicines with tumor specificity and enhanced potency.…”

Section: From Test Tube To Biological Applications: Current Challengesmentioning

confidence: 99%

Nucleic Acid Hybrids as Advanced Antibacterial Nanocarriers

Obuobi

Škalko‐Basnet

2020

Pharmaceutics

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Conventional antibiotic therapy is often challenged by poor drug penetration/accumulation at infection sites and poses a significant burden to public health. Effective strategies to enhance the therapeutic efficacy of our existing arsenal include the use of nanoparticulate delivery platforms to improve drug targeting and minimize adverse effects. However, these nanocarriers are often challenged by poor loading efficiency, rapid release and inefficient targeting. Nucleic acid hybrid nanocarriers are nucleic acid nanosystems complexed or functionalized with organic or inorganic materials. Despite their immense potential in antimicrobial therapy, they are seldom utilized against pathogenic bacteria. With the emergence of antimicrobial resistance and the associated complex interplay of factors involved in antibiotic resistance, nucleic acid hybrids represent a unique opportunity to deliver antimicrobials against resistant pathogens and to target specific genes that control virulence or resistance. This review provides an unbiased overview on fabricating strategies for nucleic acid hybrids and addresses the challenges of pristine oligonucleotide nanocarriers. We report recent applications to enhance pathogen targeting, binding and control drug release. As multifunctional next-generational antimicrobials, the challenges and prospect of these nanocarriers are included.

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Highly tumor-specific DNA nanostructures discovered by in vivo screening of a nucleic acid cage library and their applications in tumor-targeted drug delivery

Cited by 51 publications

References 43 publications

Rationally Designed DNA Nanostructures for Drug Delivery

Rationally Designed DNA Nanostructures for Drug Delivery

Structural DNA nanotechnology towards therapeutic applications

Nucleic Acid Hybrids as Advanced Antibacterial Nanocarriers

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