Highly Viscoelastic Reverse Wormlike Micellar Systems from a Mixture of Lecithin, Polyglycerol Fatty Acid Monoesters, and an Oil

Hashizaki, Kaname; Imai, Masanao; Yako, Shuhei; Tsusaka, Hitomi; Sakanishi, Yuichi; Saito, Yoshihiro; Fujii, Makiko

doi:10.5650/jos.ess17091

Cited by 5 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have identified key ingredients that can be used as substitutes for water in the preparation of LRWs in n-decane, such as urea, 8) sucrose fatty acid esters, 9) D-ribose, 10) 2-deoxy-D-ribose, 10) polyglycerols, 11) ascorbic acid, 12) and multivalent carboxylic acids. 13) The influence of amphiphilicity (i.e., hydrophile-lipophile balance) of the polar compound on the phase behavior and rheological properties of LRWs was previously investigated in detail. 14) The other main component of LRWs is oil.…”

Section: Introductionmentioning

confidence: 99%

Effect of the Physicochemical Properties of Liquid Paraffin on the Phase State and Rheological Properties of Lecithin Reverse Wormlike Micelles

Miyasaka

Hashizaki

Kono

et al. 2022

CHEMICAL & PHARMACEUTICAL BULLETIN

Self Cite

View full text Add to dashboard Cite

Lecithin reverse wormlike micelles (LRWs) have been studied recently for dermal application dosage use but the effects of the physicochemical properties of oils on the formation and rheological properties of LRWs have not been investigated. We studied the effect of oil on the formation of LRWs using 5 types of liquid paraffin (LP) with kinematic viscosities ranging from 4.00 to 88.0 mm 2 /s. Partial phase diagrams of lecithin/ water/LP systems indicated that LPs with low molecular weights could form LRWs with only a small amount of water, but LPs with high molecular weights could not form LRWs, regardless of the water concentration. The solubility of lecithin in LPs was higher for low molecular weight LPs, thus possibly affecting the formation of LRWs. The zero-shear viscosity and relaxation time of LRWs initially increased with increasing water concentration, and then decreased. The water concentration providing the maximum value was dependent on the molecular weight of the LP, whereas the maximum amount and length of the LRWs were independent of the water concentration. Our results indicate that the molecular weight of LP affects the ease of formation and the viscoelasticity of LRWs.

show abstract