Hightlights and Diagnostic Dilemma of Toxocariasis

Lee, Sang Pyo

doi:10.3904/kjm.2013.84.2.200

Cited by 6 publications

(2 citation statements)

References 7 publications

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“…Because the definite tissue confirmation of toxocariasis is extremely difficult, toxocariasis is usually diagnosed by measuring IgG antibody to Toxocara , although the currently used cutoff value cannot clearly discriminate the current active infection from remote or past infections. 1 15 30 We used commercial ELISA kits from Bordier with a sensitivity of 86% and a specificity of 91%. 17 The participants in our study are different from those of other studies in that they visited our hospital voluntarily with main concern about good health.…”

Section: Discussionmentioning

confidence: 99%

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The Prevalence of Toxocariasis and Diagnostic Value of Serologic Tests in Asymptomatic Korean Adults

Lee

Yang

Hwang

et al. 2015

Allergy Asthma Immunol Res

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PurposeToxocariasis is the most common cause of peripheral blood eosinophilia in Korea and produces eosinophilic infiltration in various organs, including the lung. However, the prevalence of toxocariasis in the general population is rarely reported.MethodsWe investigated the seroprevalence of Toxocara larval antibody among asymptomatic people who attended Samsung Medical Center for a health checkup, including low-dose chest computed tomography (CT) between March 2012 and December 2013. A total of 633 people (400 men and 233 women) were prospectively recruited.ResultsThe Toxocara-seropositive rate was 51.2% using the current cutoff value based on Toxocara enzyme-linked immunosorbent assay (ELISA) (67.0% for men and 24.0% for women). In the multivariate-adjusted model, age (odds ratio [OR], 1.08; 95% confidence intervals [CI], 1.04-1.11), male sex (OR, 3.47; 95% CI, 2.26-5.33), rural residence (OR, 1.55; 95% CI, 1.05-2.30), and history of raw liver intake (OR, 8.52; 95% CI, 3.61-20.11) were significantly associated with Toxocara seropositivity. When subjects were divided into 3 groups using cutoff values base on weak positive and strong positive control optical densities (ODs), the ORs for peripheral blood eosinophilia and serum hyperIgEaemia were 0.31 (95% CI, 0.02-2.89) in the weakpositive group and 36.64 (95% CI, 11.73-111.42) in the strong positive group compared to the seronegative group. Similarly, ORs for the solid nodule with surrounding halo were 2.54 (95% CI, 0.60-10.84) in the weak positive group and 15.08 (95 CI 4.09-55.56) in the strong positive group compared to the seronegative group.ConclusionsThe study indicated that the Toxocara-seropositive rate obtained by using the current cutoff value based on ELISA was high in the asymptomatic population in Korea. The results of this study suggest that active toxocariasis may be more frequently seen in the Toxocara-strong positive group than in the Toxocara-weak positive group.

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Section: Discussionmentioning

confidence: 99%

“…Cross-reactions with other helminth antigens may be another explanation for the higher prevalence in our study. 30 Further studies are necessary to accumulate more evidence to set the cutoff value for Toxocara infection based on ELISA.…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Toxocariasis and Diagnostic Value of Serologic Tests in Asymptomatic Korean Adults

Lee

Yang

Hwang

et al. 2015

Allergy Asthma Immunol Res

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Eosinophilic Meningitis Associated with Toxocariasis

Choi¹,

Lee²,

Park³

et al. 2015

J Neurocrit Care

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Background: Eosinophilic meningitis caused by Toxocara canis comes from neural larva migrans. It is a rare disease associated with toxocariasis. Case Report: We report a 39-year-old man who was admitted with febrile sensation, headache, and myalgia for 10 days. He had peripheral blood eosinophilia with eosinophilic meningitis. Abdominal and chest CT revealed multiple nodular infiltrations in the liver and lung. Serological test revealed that he was positive for Toxocara canis. After oral administration of steroids and albendazole, his symptoms were improved. Conclusion:We report a case of eosinophilic meningitis associated with toxocariasis.

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Diagnostic Approach to Peripheral Eosinophilia

Park¹,

Kim²

2017

Korean J Med

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Hightlights and Diagnostic Dilemma of Toxocariasis

Cited by 6 publications

References 7 publications

The Prevalence of Toxocariasis and Diagnostic Value of Serologic Tests in Asymptomatic Korean Adults

The Prevalence of Toxocariasis and Diagnostic Value of Serologic Tests in Asymptomatic Korean Adults

Eosinophilic Meningitis Associated with Toxocariasis

Diagnostic Approach to Peripheral Eosinophilia

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