Hijacked Immune Cells Traverse Microenvironmental Barriers by Positioning and Pushing their Intracellular Parasite Cargo
Mauricio J.A. Ruiz-Fernandez,
Jianfei Jiang,
Armina Mortazavi
et al.
Abstract:Intracellular pathogens hijack the cytoskeletal networks of their host cells to facilitate their uptake, drive their intracellular motility, or prevent their degradation. While many underlying principles have been explored during host cell infections by intracellular bacteria like Listeria, Chlamydia, or Shigella, it remains less well understood how large eukaryotic intracellular parasites like Toxoplasma gondii exploit the host cytoskeleton. In particular, how Toxoplasma achieves its transport within highly m… Show more
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