2019
DOI: 10.1021/acsinfecdis.9b00104
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Hijacking the Bacterial Circuitry of Biofilm Processes via Chemical “Hot-Wiring”: An Under-explored Avenue for Therapeutic Development

Abstract: Biofilm-associated infections are linked to chronic and recurring illnesses. These infections are often not susceptible to current antibiotic treatments because of the protective exocellular matrix and subpopulations of dormant or "persister" cells. Targeting bacterial circuitry involved in biofilm formation, including two-component systems, quorum sensing, polysaccharide structural integrity, and cyclic nucleotide signaling pathways, has the potential to expand the existing arsenal of therapeutics, thus catal… Show more

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