Hillside study of risk and early detection in schizophrenia

Cornblatt, Barbara A.; Obuchowski, M.; Schnur, David B.; O’Brien, John D.

doi:10.1192/s0007125000297626

Cited by 66 publications

(43 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Across all tests, lower performance during childhood predicted more prodromal symptoms in adolescence. This finding is entirely consistent with other VCFS research 47 as well as the non-VCFS schizophrenia research [70][71][72][73][74][75][76][77][78][79][80][81][82][83] . Thus, our data are entirely consistent with the extant non-VCFS high risk data; language and executive function deficits in childhood appear to presage which children with VCFS will develop significant prodromal psychotic symptoms in adolescence.…”

supporting

confidence: 81%

Cognitive and Psychiatric Predictors to Psychosis in Velocardiofacial Syndrome: A 3-Year Follow-Up Study

Antshel

Shprintzen

Fremont

et al. 2010

Journal of the American Academy of Child & Adolescent Psych

133

View full text Add to dashboard Cite

Objective-To predict prodromal psychosis in adolescents with velocardiofacial syndrome (VCFS).Method-70 youth with VCFS, 27 siblings of youth with VCFS and 25 community controls were followed from childhood (Mean age = 11.8 years) into mid-adolescence (mean age 15.0 years). Psychological tests measuring intelligence, academic achievement, learning/memory, attention and executive functioning as well as measures of parent and clinician ratings of child psychiatric functioning were completed at both time points.Results-Major depressive disorder, oppositional defiant disorder and generalized anxiety disorder diagnoses increased in the VCFS sample. With very low false positives, the best predictor of adolescent prodromal psychotic symptoms was parent ratings of childhood odd/eccentric symptoms and child performance on a measure of executive functioning, the Wisconsin Card Sorting Test.Conclusions-Similar to the non-VCFS prodromal psychosis literature, a combination of cognitive and psychiatric variables appears to predict psychosis in adolescence. A child with VCFS who screens positive is noteworthy and demands clinical attention. KeywordsVelocardiofacial syndrome (VCFS); 22q11 deletion syndrome; cognition; psychosis; longitudinal Velo-cardio-facial syndrome (VCFS) is caused by an interstitial deletion from chromosome 22 at the 22q11 band. The most common microdeletion syndrome yet identified in humans, VCFS has a population prevalence of approximately 1:2000 to 1:6000 live births 1, 2 . In most cases, VCFS is caused by a hemizygous deletion of 3 million base pairs of DNA encompassing 40 genes but approximately 8% have smaller nested deletions of 1.5 million base pairs spanning 34 genes 3 . Structural anomalies affect nearly every part and system of the body and may Correspondence to: Kevin Antshel, Ph.D. SUNY -Upstate Medical University Department of Psychiatry and Behavioral Sciences, 750 East Adams Street, Syracuse, NY 13210; AntshelK@upstate.edu. Disclosure: Dr. Faraone, in the past year, has received consulting fees and has been on Advisory Boards for Eli Lilly, Ortho-McNeil, and Shire Development, and has received research support from Eli Lilly, Pfizer, Shire and the National Institutes of Health. In previous years, Dr. Faraone has received consulting fees or has been on advisory boards, or has been a speaker for the following sources: Shire, McNeil, Janssen, Novartis, Pfizer, and Eli Lilly. In previous years he has received research support from Eli Lilly, Shire, Pfizer and the National Institutes of Health. Drs. Antshel, Shprintzen, Fremont, and Kates, and Ms. Higgins report no biomedical financial interests or potential conflicts of interest.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the prod...

show abstract

supporting

confidence: 81%

Cognitive and Psychiatric Predictors to Psychosis in Velocardiofacial Syndrome: A 3-Year Follow-Up Study

Antshel

Shprintzen

Fremont

et al. 2010

Journal of the American Academy of Child & Adolescent Psych

133

View full text Add to dashboard Cite

show abstract

“…[56][57][58][59] Previous retrospective or follow-back studies in schizophrenia 60,61 and prospective studies of offspring at high risk for schizophrenia 62,63 have described an association between nonpsychotic childhood behavioral disturbance and the subsequent development of psychotic disorders including schizophrenia. Psychopathological features such as attentional impairments occur frequently in the premorbid phase of schizophrenia, and are among the most robust markers predicting risk for schizophrenia among the offspring of schizophrenia patients 64 (for a review, see also Cornblatt et al 65 ). Alterations in the structural and biochemical integrity of the prefrontal cortex have been described in children and adolescents with ADHD, conduct disorder and bipolar disorders, 66,67 although the results are inconsistent and few 31 P MRS studies have been published in these disorders.…”

Section: Discussionmentioning

confidence: 99%

Prefrontal membrane phospholipid metabolism of child and adolescent offspring at risk for schizophrenia or schizoaffective disorder: an in vivo 31P MRS study

et al. 2003

View full text Add to dashboard Cite

In vivo31 P magnetic resonance spectroscopy ( 31 P MRS) studies have shown abnormal membrane phospholipid metabolism in the prefrontal cortex (PF) in the early course of schizophrenia. It is unclear, however, whether these alterations also represent premorbid risk indicators in schizophrenia. In this paper, we report in vivo 31 P MRS data on children and adolescents at high risk (HR) for schizophrenia. In vivo 31 P MRS studies of the PF were conducted on 16 nonpsychotic HR offspring of parents with schizophrenia or schizoaffective disorder, and 37 age-matched healthy comparison (HC) subjects. While 11 of the HR subjects had evidence of Axis I psychopathology (HR-P), five HR subjects had none (HR-NP). We quantified the freely mobile phosphomonoester (PME) and phosphodiester (PDE) levels reflecting membrane phospholipid precursors and breakdown products, respectively, and the relatively broad signal underlying PDE and PME peaks, comprised of less mobile molecules with PDE and PME moieties (eg, synaptic vesicles and phosphorylated proteins). Compared to HC subjects, HR subjects had reductions in freely mobile PME; the differences were accounted for mainly by the HR-P subjects. Additionally, HR-P subjects showed increases in the broad signal underlying the PME and PDE peaks in the PF. To conclude, these data demonstrate new evidence for decreased synthesis of membrane phospholipids and possibly altered content or the molecular environment of synaptic vesicles and/or phosphoproteins in the PF of young offspring at risk for schizophrenia. Follow-up studies are needed to examine the predictive value of these measures for future emergence of schizophrenia in at-risk individuals.

show abstract

“…These programs have proven that the innovative triad of networking with community providers, carefully targeted educational activities, and dedicated early detection teams can lead to timely referral and earlier treatment of patients with psychotic disorders. Programs like the Early Psychosis Prevention and Intervention Centre, TIPS, RAP (48), PRIME (49), and the Prevention and Early Intervention Program for Psychosis (36) also offer hope that future sufferers of schizophrenia will benefit from early interventive measures. …”

Section: Discussionmentioning

confidence: 99%

Untreated Initial Psychosis: Relation to Cognitive Deficits and Brain Morphology in First-Episode Schizophrenia

Ho¹,

Alicata²,

Ward³

et al. 2003

AJP

162

View full text Add to dashboard Cite

Hillside study of risk and early detection in schizophrenia

Cited by 66 publications

References 35 publications

Cognitive and Psychiatric Predictors to Psychosis in Velocardiofacial Syndrome: A 3-Year Follow-Up Study

Cognitive and Psychiatric Predictors to Psychosis in Velocardiofacial Syndrome: A 3-Year Follow-Up Study

Prefrontal membrane phospholipid metabolism of child and adolescent offspring at risk for schizophrenia or schizoaffective disorder: an in vivo 31P MRS study

Untreated Initial Psychosis: Relation to Cognitive Deficits and Brain Morphology in First-Episode Schizophrenia

Contact Info

Product

Resources

About