Hindlimb blood flow and oxygen usage in hemorrhagic shock.

Halmagyi, D; Goodman, A. H.; Neering, I. R.

doi:10.1152/jappl.1969.27.4.508

Cited by 16 publications

(4 citation statements)

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“…This could provide improved oxygen delivery to the systemic circulation, which may be insufficient in patients with severe respiratory failure despite the support of high-flow ECMO. 7 Even at flows approaching or exceeding the average cardiac output of the anaesthetized greyhound dog (~3.57 L/min /m 2 body surface area 11 ), V-RV ECMO exhibited minimal recirculation. The relationship between recirculation and pump flow suggests that V-RV ECMO, but not VV ECMO, can provide effective flow rates approaching cardiac output, which is crucial in obtaining adequate oxygenation in some patients with severely impaired pulmonary gas exchange.…”

Section: Discussionmentioning

confidence: 99%

Veno-right ventricular cannulation reduces recirculation in extracorporeal membrane oxygenation

et al. 2012

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Background: Veno-venous extracorporeal membrane oxygenation has several advantages over veno-arterial support for patients with severe reversible respiratory failure. However, recirculation can limit oxygen delivery as pump flow increases. This could be ameliorated by placing the return catheter in the right ventricle instead of the central veins. We compared recirculation in veno-right ventricular support with that in conventional veno-venous support and its relationship with pump flow. Methods: Five greyhound dogs were sequentially cannulated percutaneously for both veno-venous and veno-right ventricular support. Recirculation was measured by comparing oxygen levels in the circuit drainage and return lines before and immediately after a sudden increase in circuit oxygenation at pump flows between 0.5 L/min and 4 L/min for both modalities. Results: Recirculation was reduced in veno-right ventricular support compared with conventional veno-venous support at 4 L/min pump flow (8.4% versus 37.9%, p=0.0076) and increased less with increases in pump flow (2.9% per 1 L/min vs. 11.1% per 1 L/min, p<0.0001). Conclusions: Recirculation can be dramatically reduced by returning blood into the right ventricle, which improves oxygen delivery to the lungs and the systemic circulation. The design of specialized catheters may facilitate percutaneous ventricular cannulation, improve safety and further reduce recirculation.

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Section: Discussionmentioning

confidence: 99%

Veno-right ventricular cannulation reduces recirculation in extracorporeal membrane oxygenation

et al. 2012

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“…During conditions of stress, such as hem orrhage, exposure to cold, and hypoxia, the mammalian organism redistributes its circu lation to maintain homeostasis [3,9,14,15,19]. Many of the measurements commonly made in patients, such as arterial blood gases, provide no indication regarding the effects of stress on peripheral blood flow.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Peripheral Blood Flow and Blood Temperatures in Lambs during Hypoxemia and Hemorrhage

Simbruner¹,

Rudolph²

1982

Neonatology

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The relationships between the peripheral blood flow and arterial and venous blood temperatures were examined in 5 lambs (mean weight 10.5 kg, 4–12 weeks old) during hypoxemia and hemorrhage. Blood flow to one hind limb was measured continuously with an electromagnetic flow transducer around the femoral artery. Aortic and venous blood temperatures were monitored by means of thermistor catheters in the descending aorta and iliac vein. The intravascular catheters and flow transducer were implanted chronically and all studies were performed in conscious lambs, resting quietly. Skin temperatures were recorded at the hip and at the foot. The total heat in the hind limb (H_tot), the net heat transported by circulating blood (H_bl), and the metabolic heat produced in the hind limb were calculated. The arterial and venous blood temperature were related to peripheral blood flow. When the flow was constant over a control period, blood temperatures remained constant. Hypoxemia, produced by administering a low oxygen gas mixture to the lamb, did not alter femoral blood flow, nor did it affect vascular temperatures. During hemorrhage, femoral blood flow fell, aterial temperature rose by 0.46 °C and venous temperature by 0.85 °C; arteriovenous temperature difference decreased from 0.85 to 0.44 °C. There was an inverse relationship between femoral blood flow and venous temperature in each individual lamb subjected to hemorrhage, with a correlation of 0.91. For each 10-ml/min decrease in peripheral blood flow the venous temperature rose an average of 0.33 °C. Changes in peripheral blood flow were immediately reflected by changes in the venous temperature.

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“…A cannulating flowmeter probe was inserted into one femoral artery and a catheter built into the flowmeter probe was used for measuring femoral arterial pressure. Details of this technique have been described elsewhere [8],…”

Section: Methodsmentioning

confidence: 99%

Simple and Combined Adrenergic Receptor Blockade in Canine Endotoxinemia

Halmagyi¹,

Kennedy²,

Goodman³

et al. 1971

Eur Surg Res

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Circulatory, metabolic and respiratory responses to a lethal dose of purified E. coli endotoxin were determined in non-medicated (A), phenoxybenzamine-(B), propranolol-(C) and phenoxybenzamine + propranolol (D) premedicated greyhounds. Systemic and pulmonary vasoconstriction were virtually absent in A, C and D. Lactic acidosis was reduced in C and D. Distinct from hemorrhagic hypotension, plasma catecholamine level was not reduced in D. Tolerance to endotoxinemia was reduced in C and, distinct from hemorrhagic hypotension, was not convincingly improved in D. Animals surviving for 24 h were found to be in shock without any specific features and administration of isoproterenol at this stage proved to be ineffective.

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Hindlimb blood flow and oxygen usage in hemorrhagic shock.

Cited by 16 publications

References 0 publications

Veno-right ventricular cannulation reduces recirculation in extracorporeal membrane oxygenation

Veno-right ventricular cannulation reduces recirculation in extracorporeal membrane oxygenation

Relationship between Peripheral Blood Flow and Blood Temperatures in Lambs during Hypoxemia and Hemorrhage

Simple and Combined Adrenergic Receptor Blockade in Canine Endotoxinemia

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