Hint1 knockout results in a compromised activation of protein kinase C gamma in the brain

Zhang, Fan; Fang, Zhenfei; Wang, Jia Bei

doi:10.1016/j.brainres.2015.06.029

Cited by 12 publications

(15 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the study, Zhang et al found that Hint1 deficiency impaired the normal phosphorylations response of the signaling molecule PKCγ upon psycho-stimulation, particular at the sites required for the full activation of PKCγ, in the brain structures that involved in cognition and emotion-control. This finding indicates for the first time an abnormalized PKC signaling in the anxiety-related brain [2] .…”

supporting

confidence: 55%

“…To explore the critical mechanisms underlying the pathogenesis of schizophrenia, Zhang et al recently applied Hint1-knockout animal to investigate the activity of PKC in the brain [2] . The histidine triad nucleotide-binding protein-1 (Hint1), a member of the histidine triad protein family, has been found significantly down-regulated in the prefrontal cortexes of patients with schizophrenia in RNA and protein levels in clinical studies [3][4][5] .…”

mentioning

confidence: 99%

See 1 more Smart Citation

PKC Gamma-Mediated Signaling and Schizophrenia

2015

Ther Targets Neurol Dis

View full text Add to dashboard Cite

supporting

confidence: 55%

mentioning

confidence: 99%

PKC Gamma-Mediated Signaling and Schizophrenia

2015

Ther Targets Neurol Dis

View full text Add to dashboard Cite

“…Additionally, the animals respond differently to treatment with CNS-acting compounds, such as morphine (Guang et al , 2004), amphetamine (Barbier et al , 2007), and nicotine. PKCγ protein levels are elevated in Hint1 −/− mouse brains (Varadarajulu et al , 2011), yet, the PKCγ activation response upon psycho-stimulation with amphetamine is attenuated (Zhang et al , 2015). These combined findings suggest a role for HINT1 and PKCγ in modulating, among others, anxiogenic and stress-coping behaviour in mice.…”

Section: Introductionmentioning

confidence: 99%

Axonal neuropathy with neuromyotonia: there is a HINT

Peeters

Chamova

Tournev

et al. 2016

Brain

View full text Add to dashboard Cite

Mutations in HINT1 cause a common, autosomal-recessive, axonal Charcot-Marie-Tooth neuropathy, often with neuromyotonia. Peeters et al. summarize neurological aspects of the disease, epidemiology and mutation spectrum, and structural and functional characteristics of the affected protein. They propose guidelines to recognize and differentiate HINT1-neuropathy and suggest strategies to treat common symptoms.

show abstract

“…Moreover, elevated abundances of PKCγ were also detected in Hint1 haplo‐insufficiency tissue such as hippocampus, the cortex, etc. (Zhang et al., 2015). Some studies have revealed that intracellular signal transduction plays an important role in the pathophysiology of depression.…”

Section: Discussionmentioning

confidence: 99%

“…Western blotting assays were performed as previously described (Zhang, Fang, & Wang, 2015). Primary antibodies were anti‐BDNF (dilution 1:1,000; #sc‐546, Santa Cruz, Dallas, TX, USA) and anti‐β‐actin (dilution 1:1,000; #sc‐8432, Santa Cruz).…”

Section: Methodsmentioning

confidence: 99%

Effects of Hint1 deficiency on emotional‐like behaviors in mice under chronic immobilization stress

Sun

Liu

et al. 2017

Brain and Behavior

View full text Add to dashboard Cite

BackgroundHistidine triad nucleotide‐binding protein 1 (HINT1) is regarded as a haplo‐insufficient tumor suppressor and is closely associated with diverse neuropsychiatric diseases. Moreover, HINT1 is related to gender‐specific acute behavior changes in schizophrenia and in response to nicotine. Stress has a range of molecular effects in emotional disorders, which can cause a reduction in brain‐derived neurotrophic factor (BDNF) expression in the hippocampus, resulting in hippocampal atrophy and neuronal cell loss.MethodsThis study examined the role of HINT1 deficiency in anxiety‐related and depression‐like behaviors and BDNF expression in the hippocampus under chronic immobilization stress, and investigated whether the sex‐specific and haplo‐insufficient effects exist in emotional‐like behaviors under the same condition.ResultsIn a battery of behavior tests, the results of the control group, not exposed to stress, showed that knockout (KO) and heterozygosity (HT) of Hint1 had anxiolytic‐like and antidepression‐like effects on the male and female mice. However, both male and female Hint1‐KO mice showed elevated anxiety‐related and antidepression‐like behavior under chronic immobilization stress; moreover, both male and female Hint1‐HT mice displayed elevated anxiety‐related behavior and increased depression‐like behavior under chronic immobilization stress. There were no significant differences in general locomotor activity between Hint1‐KO and ‐HT mice and their wild‐type (WT) littermates. Hint1‐KO mice under basal and chronic immobilization stress conditions expressed more BDNF in the hippocampus than did Hint1‐HT and WT mice; overall, there were no significant sex differences in emotional‐like behaviors of Hint1‐KO and ‐HT mice. Additionally, Hint1‐HT mice showed haplo‐insufficient effects on emotional‐like behaviors under basic conditions, rather than under chronic immobilization stress.ConclusionsBoth male and female HINT 1 KO and HT mice had a trend of anxiolytic‐like behavior and antidepression‐like behavior at control group. However, both male and female HINT1 KO mice showed elevated anxiety‐related and antidepression‐like behavior under chronic immobilization stress; moreover, both male and female HINT1 HT mice displayed elevated anxiety‐related behavior and increased depression‐like behavior under chronic immobilization stress.

show abstract

Hint1 knockout results in a compromised activation of protein kinase C gamma in the brain

Cited by 12 publications

References 17 publications

PKC Gamma-Mediated Signaling and Schizophrenia

PKC Gamma-Mediated Signaling and Schizophrenia

Axonal neuropathy with neuromyotonia: there is a HINT

Effects of Hint1 deficiency on emotional‐like behaviors in mice under chronic immobilization stress

Contact Info

Product

Resources

About