Hip fractures in Italy: 2000–2005 extension study

Piscitelli, Prisco; Gimigliano, Francesca; Gatto, S.; Marinelli, Alessandra; Gimigliano, Alessandra; Marinelli, Paolo; Chitano, Giovanna; Greco, Marco; Luzzi, Paola; Sbenaglia, E. A.; Benvenuto, Marco; Muratore, Maurizio; Quarta, E.; Calcagnile, F.; Colí, G; Borgia, O.; Forcina, Bruno; Fitto, F.; Giordano, Antonio; Distante, Alessandro; Rossini, Maurizio; Angeli, Alberto; Migliore, Alberto; Guglielmi, Giuseppe; Guida, Giuseppe; Brandi, Maria Luisa; Gimigliano, Raffaele; Iolascon, Giovanni

doi:10.1007/s00198-009-1084-x

Cited by 51 publications

(42 citation statements)

References 38 publications

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“…This possible reversal of a secular trend is consistent with reports from other countries such as USA [13][14][15], Canada [16,17], Japan [18], Finland [19], and Denmark [20]. Similar observations were made in neighbour countries such as France [21] and Austria [22] but not in Italy [23] and Germany [24,25]. In contrast, the incidence of hospitalizations for non-hip fractures steadily increased between year 2000 and 2008 in Swiss women.…”

Section: Cost Of Hospitalizationssupporting

confidence: 88%

Comparative trends in hospitalizations for osteoporotic fractures and other frequent diseases between 2000 and 2008

et al. 2011

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Mini-AbstractIn Switzerland, the number, incidence, and cost of acute hospitalizations for major osteoporotic fractures and major cardiovascular events increased in both women and men between 2000 and 2008, although the mean length of stay was significantly reduced. Similar trend patterns were observed for hip fractures and strokes (decrease) and non-hip fractures and acute myocardial infarctions (increase). Methods : Trends in the number, age-standardized incidence, mean length of stay and cost of hospitalized MOF (hip, clinical spine, distal radius, and proximal humerus), major cardiovascular events (MCE: acute myocardial infarction, stroke, heart failure), chronic obstructive pulmonary disease (COPD), and breast carcinoma were compared in women and men aged ≥45 years, based on data from the Swiss Federal Statistical Office hospital database and population statistics.Results : Between 2000 and 2008, the age-standardized incidence of acute hospitalizations for MOF increased by 3.4% in women and 0.3% in men. In both sexes, a significant decrease in hip fractures (-15.0% and -11.0%) was compensated by a concomitant, significant increase in non-hip fractures (+24.8% and +13.8%).Similarly, the incidence of acute hospitalizations for MCE increased by 4.4% in women and 8.2% in men, as an aggregated result from significantly increasing acute myocardial infarctions and significantly decreasing strokes. While the mean length of stay in the acute inpatient setting decreased almost linearly between year 2000 and 3 2008 in all indications, the inpatient costs increased significantly (p<0.001) for MOF (+30.1%, +42.7%) and MCE (+22.6%, +47.1%) in women and men, respectively. In women in 2008, the cost of acute hospitalizations was more than threefold higher for MOF than for COPD and breast cancer and 1.5 fold higher than for any MCE. In men it was comparable to that of COPD, acute myocardial infarction, and heart failure.Conclusions : In conclusion, between year 2000 and 2008, the burden of hospitalized osteoporotic fractures to the Swiss healthcare system has continued to increase in both sexes. In women, this burden was significantly higher than that of major cardiovascular events and the gap between both disease groups widened over time.

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Section: Cost Of Hospitalizationssupporting

confidence: 88%

Comparative trends in hospitalizations for osteoporotic fractures and other frequent diseases between 2000 and 2008

et al. 2011

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“…The hip fracture incidence in our population rose markedly with age in accordance with population-based studies [30,34], although the hip fracture incidence in our cohort was higher than that reported in those studies. This might be due to the fact that our study included only females referred for DXA, whose fracture risk is presumably higher than that of the general population [34][35][36][37][38].…”

Section: Discussionmentioning

confidence: 99%

Prediction of incident hip fracture by femoral neck bone mineral density and neck–shaft angle: a 5-year longitudinal study in post-menopausal females

Gnudi¹,

Sitta²,

Pignotti³

2012

The British Journal of Radiology

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Objective: To compare hip fracture incidence in post-menopausal females who were differently stratified for the fracture risk according to bone mineral density and proximal femur geometry. Methods: In a 5 year follow-up study, the hip fracture incidence in 729 postmenopausal females (45 of whom suffered from incident hip fracture) was assessed and compared. Forward logistic regression was used to select independent predictors of hip fracture risk, including age, age at menopause, height, weight, femoral neck bone mineral density (FNBMD), neck-shaft angle (NSA), hip axis length, femoral neck diameter and femoral shaft diameter as covariates. Fracture incidence was then calculated for the categories of young/old age, high/low FNBMD and wide/narrow NSA, which were obtained by dichotomising each hip fracture independent predictor at the value best separating females with and without a hip fracture. Results: The hip fracture incidence of the whole cohort was significantly higher in females with a wide NSA (8.52%) than in those with a narrow NSA (3.51%). The combination of wide NSA and low FNBMD had the highest hip fracture incidence in the whole cohort (17.61%) and each age category. The combinations of narrow/wide NSA with low/high FNBMD, respectively, gave a significantly higher fracture incidence in older than in younger women, whereas women with a combined wide NSA and low FNBMD had no significantly different fracture incidence in young (14.60%) or old age (21.62%). Conclusion: Our study showed that NSA is effective at predicting the hip fracture risk and that the detection in early post-menopause of a wide NSA together with a low FNBMD should identify females at high probability of incident hip fracture.

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“…Hospital costs offemoral fractures in the elderly Italian population account for 1 billion Euros per year (5). Prevention of osteoporosis is traditionally based on bone measurement tests, aimed to predict the risk of future fragility fractures.…”

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confidence: 99%

Diabetes and Obesity as Independent Risk Factors for Osteoporosis in Postmenopausal Women: A Population Study

Neglia

Argentiero

Chitano³

et al. 2014

Eur J Inflamm

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We aimed to analyze bone mineralization and the effect of different risk factors for osteoporosis in postmenopausal women. We studied 2,756 postmenopausal subjects out of ≥10,000 records from the ROIS registry in the frame of the PROF Project, a population study carried out in Salento (Taranto, Brindisi, Lecce) from 2009 to 2012. All subjects were assessed by phalangeal Quantitative Ultrasound (QUS) to evaluate their bone mineralization (assessed by Amplitude Dependent Speed of Sound, AD-SoS) and the association between demineralization and the presence of other conditions or risk factors. Mean age was 64±9.5 years and mean BMI was 28.7±3.5 Kg/m2. Pearson correlation analyses revealed a negative association between bone mineralization (AD-SoS) and BMI (P<0.001). By using multivariate logistic regression analysis, we observed significant values of Odds Ratios of osteoporosis (adjusted for age, physical activity and the use of drugs known to increase the risk of fractures) in subjects with diabetes and obesity: 1.39 (CI: 1,05–1,83) and 1.46 (CI: 1.20–1.78), respectively. A statistically significant linear trend of higher Odds Ratios of osteoporosis was found for increasing values of BMI. The percent change in the odds of vertebral fractures per single SD decrease of AD-SoS was 47% (P<0.001). Diabetes and obesity in postmenopausal women are likely to represent independent risk factors for osteoporosis. Phalangeal QUS showed a good power of predictivity in identifying subjects with vertebral fractures.

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Hip fractures in Italy: 2000–2005 extension study

Abstract: Hip fractures of the elderly are increasing and represent a major health problem in industrialized countries such as Italy.

Cited by 51 publications

References 38 publications

Comparative trends in hospitalizations for osteoporotic fractures and other frequent diseases between 2000 and 2008

Comparative trends in hospitalizations for osteoporotic fractures and other frequent diseases between 2000 and 2008

Prediction of incident hip fracture by femoral neck bone mineral density and neck–shaft angle: a 5-year longitudinal study in post-menopausal females

Diabetes and Obesity as Independent Risk Factors for Osteoporosis in Postmenopausal Women: A Population Study

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