“…Amid numerous reports of high failure rates and concerning reports with ARMD, pseudotumors, and systemic complications to metal ions [1,6,9,16,19,20,24,31,35,40,46,47,53,54,56,63,65], three large-diameter MoM devices have been voluntarily recalled by the manufacturers: the Articular Surface Replacement (ASR) by DePuy (Warsaw, IN, USA), the Durom by Zimmer (Warsaw, IN, USA), and the R3 by Smith & Nephew (Memphis, TN, USA) [64]. Published studies have reported considerable variation in frequency of ARMD and failure for large-diameter devices [9,16,26,29,32,34,44,46,47,60]. Our center previously reported a higher frequency of revision in patients with MoM THA compared with metal-on-improved polyethylene THA [48].…”