Hiperbilirrubinemia severa en Recién Nacidos, factores de riesgo y secuelas neurológicas

Wagemann, Stephanie Campbell; Nannig, Patricia Mena

doi:10.32641/rchped.v90i3.772

Cited by 14 publications

(15 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Neonatal hyperbilirubinemia (NH) is caused by an elevated level of bilirubin, which is attributable to genetic or perinatal factors, maternal or neonatal causes, and other risk factors and markers [ 1 – 3 ]. Hyperbilirubinemia affects 60–80% of neonates and is the main cause of hospitalisation in the first week after birth [ 4 – 6 ], ranked the seventh leading cause of neonatal death within a week after birth worldwide [ 2 ], particularly in Africa and Southeast Asia [ 7 , 8 ]. Physiological hyperbilirubinemia is generally harmless for most newborns, except for bilirubin levels exceeding 20 or 25 mg/dl, which are considered dangerous [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

The differential value of radiomics based on traditional T1-weighted sequences in newborns with hyperbilirubinemia

Sun,

Liao,

Jia

et al. 2023

BMC Med Imaging

View full text Add to dashboard Cite

Background On the basis of visual-dependent reading method, radiological recognition and assessment of neonatal hyperbilirubinemia (NH) or acute bilirubin encephalopathy (ABE) on conventional magnetic resonance imaging (MRI) sequences are challenging. Prior studies had shown that radiomics was possible to characterize ABE-induced intensity and morphological changes on MRI sequences, and it has emerged as a desirable and promising future in quantitative and objective MRI data extraction. To investigate the utility of radiomics based on T1-weighted sequences for identifying neonatal ABE in patients with hyperbilirubinemia and differentiating between those with NH and the normal controls. Methods A total of 88 patients with NH were enrolled, including 50 patients with ABE and 38 ABE-negative individuals, and 70 age-matched normal neonates were included as controls. All participants were divided into training and validation cohorts in a 7:3 ratio. Radiomics features extracted from the basal ganglia of T1-weighted sequences on magnetic resonance imaging were evaluated and selected to set up the prediction model using the K-nearest neighbour-based bagging algorithm. A receiver operating characteristic curve was plotted to assess the differentiating performance of the radiomics-based model. Results Four of 744 radiomics features were selected for the diagnostic model of ABE. The radiomics model yielded an area under the curve (AUC) of 0.81 and 0.82 in the training and test cohorts, with accuracy, precision, sensitivity, and specificity of 0.82, 0.80, 0.91, and 0.69 and 0.78, 0.8, 0.8, and 0.75, respectively. Six radiomics features were selected in this model to distinguish those with NH from the normal controls. The AUC for the training cohort was 0.97, with an accuracy of 0.92, a precision of 0.92, a sensitivity of 0.93, and a specificity of 0.90. The performance of the radiomics model was confirmed by testing the test cohort, and the AUC, accuracy, precision, sensitivity, and specificity were 0.97, 0.92, 0.96, 0.89, and 0.95, respectively. Conclusions The proposed radiomics model based on traditional TI-weighted sequences may be used effectively for identifying ABE and even differentiating patients with NH from the normal controls, which can provide microcosmic information beyond experience-dependent vision and potentially assist in clinical diagnosis and treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

The differential value of radiomics based on traditional T1-weighted sequences in newborns with hyperbilirubinemia

Sun,

Liao,

Jia

et al. 2023

BMC Med Imaging

View full text Add to dashboard Cite

show abstract

“…As causas da icterícia neonatal estão relacionadas a diversos fatores, como prematuridade do recém-nascido, sexo masculino, amamentação, diabetes gestacional, predisposição genética, infecções do grupo TORCH (toxoplasmose, rubéola, citomegalovírus, vírus da herpes), sepse, infecções do trato urinário, entre outras complicações que podem trazer riscos à saúde do recém-nascido (Carrasco Tejerina, 2016;Rebollar-Rangel, et al;2017;Campbell Wagemann, et al;.…”

Section: Introductionunclassified

Características e efeitos da fototerapia em recém-nascidos: revisão integrativa

Faria

Ribeiro

Freitas

et al. 2021

RSD

View full text Add to dashboard Cite

O presente trabalho tem como objetivo analisar as evidências científicas acerca das características e efeitos da fototerapia em recém-nascidos. Trata-se de um estudo de revisão integrativa de literatura, realizada nas bases de dados Literatura Latino Americana e do Caribe em Ciências de Saúde (LILACS), Sistema Online de Busca e Análise de Literatura Médica (MEDLINE) e Web of Science, com estratégias de busca com Descritores de Ciências da Saúde (DECS) e Medical Subject Headings (MeSH). Foram selecionados para análise 19 artigos no período entre 2011 a 2019, a partir da questão de revisão e dos critérios de inclusão. A análise dos estudos revelou dentre as evidências científicas: os tipos de fototerapia, sendo: convencional, diodo emissor de luz (LED), LED dupla, contínua e intermitente. E, a outra evidência encontrada foi acerca dos efeitos e usos da fototerapia, como: a variabilidade da frequência cardíaca, estresse oxidativo, diminuição da globulina sérica, hipocalcemia, epilepsia, aumento de metabólitos. A fototerapia é benéfica, pois degrada a bilirrubina sérica evitando complicações como a Síndrome de Kernicterus. Porém, o seu uso indiscriminado deve ser revisto e sua utilização necessita ser criteriosa para evitar a sessões de fototerapia em casos em que a bilirrubina não tenha atingido os níveis recomendados. Destaca-se a atuação da enfermagem no cuidado ao recém-nascido em fototerapia e necessita ter sua prática pautada em evidências científicas, uma vez que qualifica e humaniza o cuidado a partir das necessidades biopsicossociais, além desta qualificação permitir a melhor escolha de assistência ao recém-nascido e sua família.

show abstract

“…1 As bilirubin levels increase, there is a risk of neurological toxicity or bilirubin encephalopathy. 1,2 Hyperbilirubinemia may cause complications such as intellectual deficits, neuromotor problems, hearing loss, and speech disorders. 3 Therefore, the early diagnosis and treatment of hyperbilirubinemia is essential for infant health.…”

mentioning

confidence: 99%

“…Hyperbilirubinemia is a condition in which excess bilirubin accumulates in the blood in the neonatal period, causing yellowing of the skin, sclera, and other organs 1. As bilirubin levels increase, there is a risk of neurological toxicity or bilirubin encephalopathy 1,2. Hyperbilirubinemia may cause complications such as intellectual deficits, neuromotor problems, hearing loss, and speech disorders 3.…”

mentioning

confidence: 99%

The Effect of Abdominal Massage on Bilirubin Levels in Term Infants Receiving Phototherapy

Köse,

Gözen,

Karadağ Aytemiz

et al. 2024

Advances in Neonatal Care

View full text Add to dashboard Cite

Background: The incidence of neonatal hyperbilirubinemia in Europe and the United States is estimated to be 3.2 and 4.4 per 10,000 live births, respectively. Abdominal massage for hyperbilirubinemia is considered a safe complementary treatment for infants that may increase number of defecations and decrease bilirubin levels. Purpose: This study was designed as a randomized controlled trial to determine the effect of abdominal massage on bilirubin levels in term infants receiving phototherapy. Methods: The sample consisted of 43 term newborns (intervention group: 23; control group: 20) who received phototherapy in a university hospital between June 2019 and February 2021. Information and observation forms were used for data collection. The intervention group received 6 abdominal massages over 2 days, performed 3 times a day, 6 hours apart, and lasting 5 minutes each. Results: Transcutaneous bilirubin levels and heart rate were significantly lower in the intervention group than in the control group at 48 hours (P = .015 and P = .033, respectively). Number of defecations was higher in the intervention group at 24 hours (P = .007) but there was no significant difference at 48 hours. The decrease in serum bilirubin between 24 and 48 hours was significantly greater in the intervention group (P = .005). Implication for Practice and Research: Abdominal massage was effective in reducing bilirubin levels and may increase the number of defecations. Providing massage training to the parents of infants who are discharged early could be a protective approach to prevent the rise in bilirubin levels.

show abstract

Hiperbilirrubinemia severa en Recién Nacidos, factores de riesgo y secuelas neurológicas

Cited by 14 publications

References 23 publications

The differential value of radiomics based on traditional T1-weighted sequences in newborns with hyperbilirubinemia

The differential value of radiomics based on traditional T1-weighted sequences in newborns with hyperbilirubinemia

Características e efeitos da fototerapia em recém-nascidos: revisão integrativa

The Effect of Abdominal Massage on Bilirubin Levels in Term Infants Receiving Phototherapy

Contact Info

Product

Resources

About