“…Having said that, very severe reactions with systemic symptoms to mosquito bites could develop in patients with Epstein-Barr virus-associated T/natural-killer cell-associated lymphoproliferative disorders [10]. However, naturally acquired desensitization to mosquito saliva is more common in children ('skeeter syndrome'), with local allergic reactions that usually improve spontaneously with age, during long-term exposure to mosquito bites or both [11,12]. The reactions to mosquito bites are immunologically mediated in nature, that include severe local and systemic reactions involve immunoglobulin E, immunoglobulin G, and T-lymphocytemediated hypersensitivities in response to allergens in mosquito saliva [13].…”