Hippocampal and entorhinal atrophy in mild cognitive impairment

Devanand, Davangere P.; Pradhaban, Gnanavalli; Liu, X.; Khandji, Alexander G.; Santi, Susan De; Segal, S.; Rusinek, Henry; Pelton, Gregory H.; Honig, Lawrence S.; Mayeux, Richard; Stern, Yaakov; Tabert, Matthias H.; Leon, Mony J. de

doi:10.1212/01.wnl.0000256697.20968.d7

Cited by 688 publications

(506 citation statements)

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“…Increased rates of atrophy of medial temporal regions have been associated with decline to AD Buckner et al, 2005;Chetelat et al, 2005;Desikan et al, 2008). Baseline hippocampal measures have also been demonstrated to predict future conversion to AD (Jack et al, 2005;den Heijer et al, 2006;Devanand et al, 2007Devanand et al, , 2008Fleisher et al, 2008;Risacher et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Hippocampal Subregions are Differentially Affected in the Progression to Alzheimer's Disease

Greene

Killiany

2011

The Anatomical Record

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Atrophy within the hippocampus (HP) as measured by magnetic resonance imaging (MRI) is a promising biomarker for the progression to Alzheimer's disease (AD). Subregions of the HP along the longitudinal axis have been found to demonstrate unique function, as well as undergo differential changes in the progression to AD. Little is known of relationships between such HP subregions and other potential biomarkers, such as neuropsychological (NP), genetic, and cerebral spinal fluid (CSF) beta amyloid and tau measures. The purpose of this study was to subdivide the hippocampus to determine how the head, body, and tail were affected in normal control, mild cognitively impaired, and AD subjects, and investigate relationships with HP subregions and other potential biomarkers. MRI scans of 120 participants of the Alzheimer's Disease Neuroimaging Initiative were processed using FreeSurfer, and the HP was subdivided using 3D Slicer. Each subregion was compared among groups, and correlations were used to determine relationships with NP, genetic, and CSF measures. Results suggest that HP subregions are undergoing differential atrophy in AD, and demonstrate unique relationships with NP and CSF data. Discriminant function analyses revealed that these regions, when combined with NP and CSF measures, were able to classify by diagnostic group, and classify MCI subjects who would and would not progress to AD within 12 months. Anat Rec,

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Section: Introductionmentioning

confidence: 99%

Hippocampal Subregions are Differentially Affected in the Progression to Alzheimer's Disease

Greene

Killiany

2011

The Anatomical Record

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“…The majority of experimental studies so far employed manual volumetric techniques to determine volumes of hippocampus, amygdala, entorhinal cortex, and other subregions of medial temporal lobe [12,25,50]. Few studies have employed semi-automated techniques to determine hippocampus volume, accounting for more than 80% of variation in manual measurements [7,21].…”

Section: Introductionmentioning

confidence: 99%

“…Few studies have employed semi-automated techniques to determine hippocampus volume, accounting for more than 80% of variation in manual measurements [7,21]. Manual hippocampus volume reaches about 70% accuracy [12,26] in the prediction of AD in patients with mild cognitive impairment (MCI), an at risk group of AD [32], and between 80 to 90% accuracy in the discrimination between patients with AD and healthy control subjects [17,18]. Levels of accuracy are similar for amygdala volumetry, but less well established in comparison to hippocampus volumetry [50].…”

Section: Introductionmentioning

confidence: 99%

Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease

Teipel

Ewers

Wolf

et al. 2010

Psychiatry Research: Neuroimaging

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MRI based volumetry of the hippocampus and amygdala has been suggested as a biomarker of Alzheimer's disease (AD). For validation of the candidate marker, however, effects of multicentre acquisition on measurement variability have to be considered. In the present study we determined effects of multicentre acqusitions of MRI data across 12 clinical sites within the German Competence Network on Dementias in 113 patients with clinically probable AD and 150 patients with amnestic mild cognitive impairment (MCI). Hippocampus and amygdala volumes were significantly reduced in AD compared to MCI patients using data pooled across centres. The between-centre effect accounted for 5 to 15% of within-centre variability. Using mixed effects regression, we found specific correlations between delayed recall of verbal and non-verbal material and global cognitive measures with hippocampus and amygdala volumes. In contrast drawing performance was not correlated with volume measures. ApoE4 genotype had no effect on volumetric measures. Power analysis for the detection of a difference in the volumes between AD and MCI patients across centres showed that multicentre variability did not significantly affect effect sizes. The total sample size needed is N= 58 for hippocampus and N= 158 for amygdala volumes. Our data indicate that multicentre acquisition of MRI data using manual volumetry is reliable and feasible for diagnostic trials and replicates essential findings from smaller scale monocentre studies.3

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“…Клетки места и клетки решетки находятся в структурах мозга, которые в первую очередь страдают при болезни Альцгеймера [17,18]. Поэтому у больных болезнью Альцгеймера нарушаются не только процессы запоминания и вспоминания, но и пространственное ориентирование.…”

Section: казанович мысин 90unclassified

How Animals Find Their Way in Space. Experiments and Modeling

Казанович¹,

Kazanovich²

2015

Math.Biol.Bioinf.

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Аннотация. Нобелевская премия по физиологии и медицине за 2014 год была присуждена Джону О'Кифу, Мэй-Бритт Мозер и Эдварду Мозеру за открытие клеток места и клеток решетки, являющихся важными компонентами нейронной системы ориентации млекопитающих в пространстве. Данный обзор посвящен объяснению сущности сделанных открытий и описанию основных свойств клеток места и клеток решетки. Будут также приведены примеры математических моделей ориентации, основанные на экспериментальных результатах, полученных нобелевскими лауреатами.Ключевые слова: система пространственной ориентации, гиппокамп, энторинальная кора, тета-ритм, фазовая прецессия, клетки места, клетки решетки.

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Hippocampal and entorhinal atrophy in mild cognitive impairment

Cited by 688 publications

References 45 publications

Hippocampal Subregions are Differentially Affected in the Progression to Alzheimer's Disease

Hippocampal Subregions are Differentially Affected in the Progression to Alzheimer's Disease

Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease

How Animals Find Their Way in Space. Experiments and Modeling

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