Hippocampal and thalamic atrophy in mild temporal lobe epilepsy

Labate, Angelo; Cerasa, Antonio; Gambardella, Antonio; Aguglia, Umberto; Quattrone, Aldo

doi:10.1212/01.wnl.0000326898.05099.04

Cited by 100 publications

(128 citation statements)

References 34 publications

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“…2,3 Moreover, using voxel-based morphometry and cortical thickness we have confirmed mesial temporal lobe, parietal lobe, and thalamic abnormalities that were remarkably comparable to what is observed in patients with refractory TLE regardless of the presence of Hs. 4,5 Of interest, our observations in benign TLE are consistent with the brain regions reported by Keller et al 1 This finding further enlarges the thalamocortical network being observed, even in patients with very mild epilepsy.…”

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confidence: 92%

“…Moreover and very exciting, we found the same pattern of thalamic damage in patients with benign TLE, without radiologic evidence of Hs and normal hippocampal volumetry. 4,5 All these data 1,[4][5][6][7] support that the thalamus is centrally involved in the epileptogenic network of TLE, as also suggested by postsurgical studies reporting that the prognosis could be related to the extension of the epileptogenic network to the subcortical thalamic structure in TLE. 8 Obviously as Keller et al highlighted, 1 all evidence of thalamic structural abnormalities are derived from T 1 -weighted magnetic resonance imaging (MRI) scans only and details on brain connectivity are still lacking and deserve more attention with larger samples.…”

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confidence: 62%

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confidence: 92%

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confidence: 62%

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Epilepsia

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“…In humans, an image analysis method in which brain volume determined by MR images is analyzed by on a voxel-by-voxel basis (Voxel-Based Morphometry) 29 and another method where the hippocampus area is divided by intracranial area 7,29 are used. Voxel based morphometry requires a database of normal images for comparison.…”

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confidence: 99%

Clinical Magnetic Resonance Volumetry of the Hippocampus in 58 Epileptic Dogs*

Kuwabara

Hasegawa

Kobayashi

et al. 2010

Veterinary Radiology &Amp; Ultrasound

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Hippocampal atrophy, which is a component of hippocampal sclerosis and recognized commonly in human intractable epilepsy, is controversial in canine epilepsy. We examined the hippocampal volume in 58 epileptic dogs and 35 control dogs using magnetic resonance (MR) images, and calculated the relative hippocampal volume asymmetry of the right and left hippocampus. Subjectively, there were visible MR imaging abnormalities in seven of the 58 epileptic dogs (12%). The hippocampel volume asymmetric ratio of epileptic dogs (5.84 AE 4.47%) was significantly greater than that of control dogs (1.62 AE 0.88%). Using a cutoff threshold asymmetric ratio of 6% that is indicated in human epilepsy, 28 epileptic dogs (48%) were characterized as having unilateral hippocampus atrophy. The hippocampal volume asymmetry ratio cannot be used to detect bilateral atrophy. In conclusion, although less frequent than that observed in human epilepsy patients, hippocampal atrophy may occur in canine epilepsy. r

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“…We also used 3 different advanced structural neuroimaging operator-independent approaches, called shape analysis, 6 voxelbased morphometry, 7,8 and automated hippocampal segmentation (FreeSurfer; http://surfer.nmr.mgh.harvard.edu/) 9,10 to determine whether Hh seen on visual MR imaging could have masked occult atrophy.…”

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confidence: 99%

Advanced MRI Morphologic Study Shows No Atrophy in Healthy Individuals with Hippocampal Hyperintensity

Labate

Cerasa

Cherubini

et al. 2013

AJNR Am J Neuroradiol

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SUMMARY:We have already shown that brain MR imaging of healthy individuals frequently reveals either unilateral or bilateral Hh, which is considered a hallmark of hippocampal sclerosis. We performed a follow-up (5-year interval) clinical and advanced imaging study of these individuals to address whether Hh may have masked occult brain atrophy or contributed to a later onset of epilepsy. Subjects with Hh (n ϭ 13) underwent a detailed clinical-imaging protocol, with a 3T scan and were studied with automated hippocampal segmentation (FreeSurfer), whole brain voxel-based morphometry, and shape analysis. All 13 subjects with Hh had normal neurologic examination findings with no cognitive impairment. Multimodal structural neuroimaging methods did not show clear evidence of significant volumetric changes between subjects with or without Hh. We clearly showed that Hh is not associated with any occult brain atrophy; furthermore, none of the healthy subjects with MR imaging evidence of Hh developed epilepsy or trouble with cognition. ABBREVIATIONS:FDR ϭ false discovery rate; Hh ϭ hippocampal hyperintensity; Hs ϭ hippocampal sclerosis; TLE ϭ temporal lobe epilepsy; VBM ϭ voxel-based

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Hippocampal and thalamic atrophy in mild temporal lobe epilepsy

Cited by 100 publications

References 34 publications

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Clinical Magnetic Resonance Volumetry of the Hippocampus in 58 Epileptic Dogs*

Advanced MRI Morphologic Study Shows No Atrophy in Healthy Individuals with Hippocampal Hyperintensity

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