Hippocampal atrophy predicts conversion to dementia after STN-DBS in Parkinson's disease

Neurodegeneration Across Stages of Cognitive Decline in Parkinson Disease

“…This suggests that a diffuse pattern of GM and WM brain atrophy can be detected at an early stage of cognitive decline in PD if sensitive imaging analyses are used. Because the use of traditional imaging methods in PD patients has produced mixed results regarding the correlation between atrophy and current and future cognitive performance, 40,41 additional research is needed to determine whether the pattern classifier for PDD is able to predict cognitive decline in nondemented PD patients, as has been reported for individuals with MCI in the general population. 27 …”

Limbic Neuromodulation

“…For example, hippocampal atrophy and volume have been used to predict the onset of dementia. 50–52 Other regions with connectivity to the hippocampus and fornix include the mammillary bodies, anterior nucleus of the thalamus, cingulate gyrus, and basal forebrain cholinergic nuclei.…”

Deep Brain Stimulation and Cognitive Decline in Parkinson’s Disease: A Clinical Review

“…Nonetheless, they agree that further studies should be conducted in order to define risk factors for developing dementia after DBS, especially because 36% of patients developing dementia did so within 6 months after surgery, suggesting a triggering effect of the procedure or the stimulation. From the same group, a longer observation period which included additional subjects has shown that 20% of patients (14/70) developed dementia on average 25 months after surgery (Aybek et al, 2009). …”

“…These were compared with 14 controls and the authors have found that hippocampal atrophy is a predictor of dementia in PD patients converting to dementia after subthalamic DBS (Aybek et al, 2009). …”