Hippocampal c-fos is necessary for long-term memory of a socially transmitted food preference

Countryman, Renee A.; Kaban, Nicole L.; Colombo, Paul J.

doi:10.1016/j.nlm.2005.07.005

Cited by 65 publications

(59 citation statements)

References 24 publications

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“…Control groups of ten rats each were mockinjected intracranially on the same days with phosphate-buffered saline. This control has been used for the following reasons instead of sense or scrambled oligo controls: (1) abundant literature on saline as antisense control for in vivo studies [15][16][17][18], (2) abundant published data on lack of sense and scrambled oligo effects as opposed to antisense [19][20][21], and (3) lack of sense effects in our previous in vitro experiments [6]. Importantly, in drug development, complete drug is normally compared to its solvent/vehicle, in our case, saline, but not to a modified and inactive drug (e.g., sense).…”

Section: Surgical Procedures and Treatment With Polycefinmentioning

confidence: 99%

Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier reduces glioma angiogenesis

et al. 2006

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We have previously shown that laminin-8, a vascular basement membrane component, was overexpressed in human glioblastomas multiforme and their adjacent tissues compared to normal brain. Increased laminin-8 correlated with shorter glioblastoma recurrence time and poor patient survival making it a potential marker for glioblastoma diagnostics and prediction of disease outcome. However, laminin-8 therapeutic potential was unknown because the technology of blocking the expression of multi-chain complex proteins was not yet developed. To inhibit the expression of laminin-8 constituents in glioblastoma in vitro and in vivo, we used Polycefin, a bioconjugate drug delivery system based on slime-mold Physarum polycephalum-derived poly(malic acid). It carries an attached transferrin receptor antibody to target tumor cells and to deliver two conjugated morpholino antisense oligonucleotides against laminin-8 α4 and β1 chains. and area (p < 0.001) and increased animal survival (p < 0.0004). These data suggest that laminin-8 may be important for glioblastoma angiogenesis. Polycefin, a versatile nanoscale drug delivery system, was suitable for in vivo delivery of two antisense oligonucleotides to brain tumor cells causing a reduction of glioblastoma angiogenesis and an increase of animal survival. This system may hold promise for future clinical applications.

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Section: Surgical Procedures and Treatment With Polycefinmentioning

confidence: 99%

Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier reduces glioma angiogenesis

et al. 2006

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“…However, the functional significance of the up-regulation of c-fos gene expression and Fos protein synthesis in these brain sites remains unclear. Several studies have shown that reversible blockage of Fos protein production by the application of a specific antisense oligodeoxynucleotide (AS-ODN) against c-fos mRNA (c-fos AS-ODN) in the brain is useful for studying the function of the c-fos gene and Fos protein (7,(24)(25)(26). Here, we studied the potential roles of Fos protein in the PBN, AMY, and IC in CTA formation using the AS-ODN-mediated disruption of Fos production in vivo.…”

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confidence: 99%

Acute suppression, but not chronic genetic deficiency, of c- fos gene expression impairs long-term memory in aversive taste learning

Yasoshima

Sako

Senba

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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“…In the current experiment, although NBM-stimulated rats showed more immunoreactive cells in the ventral subiculum than controls, no statistically significant differences were found between groups. Nevertheless, hippocampal-lesioned rats normally acquire and briefly retain the food odor association as demonstrated by intact memory immediately after social training (Bunsey and Eichenbaum 1995), and it has been reported that hippocampal administration of c-fos antisense impairs long-term STFP memory as tested two weeks after training but leaves immediate memory intact (Countryman et al 2005a). Accordingly, increases in c-Fos expression in dorsal CA or ventral DG after pretraining NBM stimulation might better account for 24-h retention facilitation as opposed to the greater immediate retention, which might be better explained by prefrontal activation, as discussed above.…”

Section: Discussionmentioning

confidence: 99%

“…This flexible memory expression is a key feature of relational memory (Bunsey and Eichenbaum 1995;Eichenbaum 1999;Alvarez et al 2001). The integrity of the hippocampus and related areas is necessary for expression of the socially transmitted odor association (Winocur 1990;Bunsey and Eichenbaum 1995;Kogan et al 1997;Mayeux-Portas et al 2000;Rampon et al 2000;Alvarez et al 2001;Winocur et al 2001;Clark et al 2002;Roberts and Shapiro 2002;Brightwell et al 2005;Countryman et al 2005a;Ross and Eichenbaum 2006). Moreover, several studies show that STFP learning is sensitive to selective cholinergic NBM damage (Berger-Sweeney et al 2000;Vale-Martinez et al 2002), suggesting a critical role of NBM neurons in acquisition and early consolidation of the task.…”

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confidence: 99%

Effects of nucleus basalis magnocellularis stimulation on a socially transmitted food preference and c-Fos expression

Boix-Trelis¹,

Vale-Martínez²,

Guillazo-Blanch³

et al. 2006

Learn. Mem.

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Experiment 1 examined the effects of electrical stimulation of nucleus basalis magnocellularis (NBM) on a relational odor-association task-the social transmission of food preference (STFP). Rats were stimulated unilaterally in the NBM for 20 min (100 µA, 1 Hz) immediately before the social training. They were tested on their ability to remember preference for the trained food either immediately or following a 24-h delay. Stimulation of NBM improved retention regardless of delay, and additional behavioral measures (social interaction, motor activity, or exploration) did not account for such effects. Experiment 2 investigated brain regions activated after NBM electrical stimulation by examining the induction of c-Fos. This treatment led to bilateral increased c-Fos expression in prefrontal regions, such as orbitofrontal, prelimbic, and infralimbic cortices, and some hippocampal subregions (dorsal CA and ventral dentate gyrus). In contrast, no differences between groups in c-Fos expression were found in basolateral amygdala, dorsal dentate gyrus, ventral CA, or ventral subiculum. Present findings indicate that pretraining NBM electrical stimulation facilitates the acquisition of STFP, supporting a role of NBM in the early stages of memory formation, and suggest that the treatment might cause such effects by inducing neural changes, related to transcription factors such as c-Fos, in the prefrontal cortex or the hippocampal formation.

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Hippocampal c-fos is necessary for long-term memory of a socially transmitted food preference

Cited by 65 publications

References 24 publications

Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier reduces glioma angiogenesis

Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier reduces glioma angiogenesis

Acute suppression, but not chronic genetic deficiency, of c- fos gene expression impairs long-term memory in aversive taste learning

Effects of nucleus basalis magnocellularis stimulation on a socially transmitted food preference and c-Fos expression

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