Hippocampal CA field neurogenesis after pilocarpine insult: The hippocampal fissure as a neurogenic niche

Zhang, Limei; Hernández, Vito S.; Estrada, Felipe S.; Luján, Rafael

doi:10.1016/j.jchemneu.2014.02.002

Cited by 11 publications

(11 citation statements)

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“…Vestigial structures around an extension of the lateral ventricle with migrating cells in chains, bipolar cells and thread‐like fibers have been reported (Curtis et al, ). In rodents, the hippocampal fissure, equivalent to the sulcus in humans, has also been identified as a niche and further potential source of progenitor cells in adult animals (Zhang et al, ). A further migratory stream has been described in mice extending from the hippocampal fimbra to dentate, composed of radial‐glial like cells, which persists into adulthood (Belmadani et al, ).…”

Section: Discussionmentioning

confidence: 99%

Nestin‐expressing cell types in the temporal lobe and hippocampus: Morphology, differentiation, and proliferative capacity

Liu

Reeves

Jacques

et al. 2017

Glia

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Nestin is expressed in immature neuroepithelial and progenitor cell types and transiently upregulated in proliferative neuroglial cells responding to acute brain injury, including following seizures. In 36 temporal lobe (TLobe) specimens from patients with TLobe epilepsy (age range 8–60 years) we studied the number, distribution and morphology of nestin‐expressing cells (NEC) in the pes, hippocampus body, parahippocampal gyrus, amygdala, temporal cortex and pole compared with post mortem control tissues from 26 cases (age range 12 gestational weeks to 76 years). The proliferative fraction of NEC was evaluated in selected regions, including recognized niches, using MCM2. Their differentiation was explored with neuronal (DCX, mushashi, βIII tubulin, NeuN) and glial (GFAP, GFAPdelta, glutamine synthetase, aquaporin4, EAAT1) markers, both in sections or following culture. Findings were correlated with clinical parameters. A stereotypical pattern in the distribution and morphologies of NEC was observed, reminiscent of patterns in the developing brain, with increased densities in epilepsy than adult controls (p < .001). Findings included MCM2‐positive radial glial‐like cells in the periventricular white matter and rows of NEC in the hippocampal fimbria and sulcus. Nestin cells represented 29% of the hippocampal proliferative fraction in epilepsy cases; 20% co‐expressed βIII tubulin in culture compared with 28% with GFAP. Significant correlations were noted between age at surgery, memory deficits and nestin populations. TLobe NEC with ongoing proliferative capacity likely represent vestiges of developmental migratory streams and resident reactive cell populations of potential relevance to hippocampal epileptogenesis, TLobe pathology, and co‐morbidities, including memory decline.

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Section: Discussionmentioning

confidence: 99%

Nestin‐expressing cell types in the temporal lobe and hippocampus: Morphology, differentiation, and proliferative capacity

Liu

Reeves

Jacques

et al. 2017

Glia

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“…Furthermore, AHN provides plasticity required in memory processes and allows for “pattern separation mechanisms, ” which is crucial for memory consolidation (Bruel-Jungerman et al, 2007 ; Sahay et al, 2011a ; Bekinschtein et al, 2013 ; Yassa and Reagh, 2013 ). It is critical to understand this phenomenon because neurogenesis also occurs after brain injury or during brain alteration (e.g., epilepsy); however, in these cases, it is a non-functional process as it is not related with their normal brain function and does not involve wiring of new neurons into networks (Zhang et al, 2014 ).…”

Section: Adult Neurogenesismentioning

confidence: 99%

A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis

Ortega-Martínez

2015

Front. Mol. Neurosci.

218

133

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Adult neurogenesis is the process by which new neurons are generated in the brains of adults. Since its discovery 50 years ago, adult neurogenesis has been widely studied in the mammalian brain and has provided a new perspective on the pathophysiology of many psychiatric and neurodegenerative disorders, some of which affect memory. In this regard, adult hippocampal neurogenesis (AHN), which occurs in the subgranular zone (SGZ) of the dentate gyrus (DG), has been suggested to play a role in the formation and consolidation of new memories. This process involves many transcription factors, of which cyclic AMP (cAMP)-responsive element-binding protein (CREB) is a well-documented one. In the developing brain, CREB regulates crucial cell stages (e.g., proliferation, differentiation, and survival), and in the adult brain, it participates in neuronal plasticity, learning, and memory. In addition, new evidence supports the hypothesis that CREB may also participate in learning and memory through its involvement in AHN. This review examines the CREB family of transcription factors, including the different members and known signaling pathways. It highlights the role of CREB as a modulator of AHN, which could underlie its function in memory consolidation mechanisms.

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“…EphA4 is associated with apoptosis of neural cells in the hippocampus, and maintains neural stem/progenitor cells (NSC/NPC) in an undifferentiated state; its downregulation may therefore damage NPC proliferation and accelerate premature differentiation (18,28). Recently, it has been discovered that neurogenesis may exist in the CA fields serving as a vascular stem cell niche post-SE (6). Although in the present study EphA4 dynamic expression was associated with angiogenesis affected by seizures in the CA1 and CA3 areas, whether EphA4 is involved in this novel niche requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

“…Following SE, there are a series of pathophysiological processes in the hippocampal Cornu Ammonis (CA) areas that reorganize the epileptogentic neurological networks. Neurodegeneration (4,5), neurogenesis (6), mossy fiber sprouting (MFS) (3,7) and dendrite spine plasticity (8,9) are the most extensively described pathological changes. These neurobiological phenomena require excessive oxygen and glucose.…”

Section: Introductionmentioning

confidence: 99%

EphA4 may contribute to microvessel remodeling in the hippocampal CA1 and CA3 areas in a mouse model of temporal lobe epilepsy

Feng

Shu

Qian

et al. 2016

Molecular Medicine Reports

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Unclustered and pre-clustered ephrin-A5-Fc have identical anti-epileptic effects in the dentate gyrus of hippocampus in a mouse model of temporal lobe epilepsy (TLE), and act through alleviating ephrin receptor A4 (EphA4)-mediated neurogenesis and angiogenesis. However, the effects of ephrin-A5-Fcs on EphA4 and angiogenesis in Cornu Ammonis (CA)1 and CA3 areas remain unclear. In the present study, male C57BL/6 mice underwent pilocarpine-induced TLE. The expression of EphA4 and ephrin-A5 proteins was analyzed by immunohistochemistry, and the mean density and diameter of platelet endothelial cell adhesion molecule-1-labeled microvessels in CA1 and CA3 were calculated in the absence or presence of two types of ephrin-A5-Fc intrahippocampal infusion. Microvessels perpendicular to the pyramidal cell layer decreased; however, microvessels that traversed the layer increased, and became distorted and fragmented. The mean densities and diameters of microvessels gradually increased and remained greater than those in the control group at 56 days post-status epilepticus (SE). The upregulation of EphA4 and ephrin-A5 proteins began at 7 days and was maintained until 28 days, subsequently decreasing slightly at 56 days post-SE. Blockade of EphA4 by unclustered-ephrin-A5-Fc effected a reduction in the mean density and mean diameter of microvessels in the CA1 and CA3 areas; conversely, activation of EphA4 by clustered-ephrin-A5-Fc induced an increase in these values. Ephrin-A5 ligand binding to EphA4 receptor may contribute to angiogenesis during epileptogenesis in the hippocampal CA1 and CA3 areas.

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Hippocampal CA field neurogenesis after pilocarpine insult: The hippocampal fissure as a neurogenic niche

Cited by 11 publications

References 50 publications

Nestin‐expressing cell types in the temporal lobe and hippocampus: Morphology, differentiation, and proliferative capacity

Nestin‐expressing cell types in the temporal lobe and hippocampus: Morphology, differentiation, and proliferative capacity

A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis

EphA4 may contribute to microvessel remodeling in the hippocampal CA1 and CA3 areas in a mouse model of temporal lobe epilepsy

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