Hippocampal cell proliferation and spatial memory performance after social instability stress in adolescence in female rats

McCormick, Cheryl M.; Nixon, Feather; Thomas, C. R.; Lowie, Bobbi; Dyck, Joshua J.

doi:10.1016/j.bbr.2009.11.003

Cited by 74 publications

(77 citation statements)

References 83 publications

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“…Furthermore, the effects are often sex-specific (e.g., Hodes and Shors, 2005;Wright et al, 2008;Barha et al, in press), and the studies of hippocampal function were limited to males. We found decreased spatial location memory in adult females exposed to adolescent social instability (McCormick et al, 2010b). There was reduced neurogenesis in SS females compared to CTL females, but measures were obtained only at postnatal day 48.…”

Section: Discussionmentioning

confidence: 61%

Social instability stress in adolescent male rats alters hippocampal neurogenesis and produces deficits in spatial location memory in adulthood

McCormick¹,

Thomas²,

Sheridan³

et al. 2011

Hippocampus

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105

127

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The ongoing development of the hippocampus in adolescence may be vulnerable to stressors. The effects of social instability stress (SS) in adolescence (daily 1 h isolation and change of cage partner postnatal days 30-45) on cell proliferation in the dentate gyrus (DG) in adolescence (on days 33 and 46, experiment 1) and in adulthood (experiment 2) was examined in Long Evans male rats and compared to nonstressed controls (CTL). Additionally, in experiment 2, a separate group of SS and CTL rats was tested on either a spatial (hippocampal-dependent) or nonspatial (nonhippocampal dependent) version of an object memory test and also were used to investigate hippocampal expression of markers of synaptic plasticity. No memory impairment was evident until the SS rats were adults, and the impairment was only on the spatial test. SS rats initially (postnatal day 33) had increased cell proliferation based on counts of Ki67 immunoreactive (ir) cells and greater survival of immature neurons based on counts of doublecortin ir cells on day 46 and in adulthood, irrespective of behavioral testing. Counts of microglia in the DG did not differ by stress group, but behavioral testing was associated with reduced microglia counts compared to nontested rats. As adults, SS and CTL rats did not differ in hippocampal expression of synaptophysin, but compared to CTL rats, SS rats had higher expression of basal calcium/calmodulin-dependent kinase II (CamKII), and lower expression of the phosphorylated CamKII subunit threonine 286, signaling molecules related to synaptic plasticity. The results are contrasted with those from previous reports of chronic stress in adult rats, and we conclude that adolescent stress alters the ongoing development of the hippocampus leading to impaired spatial memory in adulthood, highlighting the heightened vulnerability to stressors in adolescence.

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Section: Discussionmentioning

confidence: 61%

Social instability stress in adolescent male rats alters hippocampal neurogenesis and produces deficits in spatial location memory in adulthood

McCormick¹,

Thomas²,

Sheridan³

et al. 2011

Hippocampus

Self Cite

105

127

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“…Notably, despite significant behavioral changes, there were no alterations in hippocampal neurogenesis in IUGR female rats as a consequence of exposure to SDS in this study. In non-IUGR mammals, some studies have documented correlations between hippocampal neurogenesis and a variety of behavioral responses (McCormick et al, 2010;Ming and Song, 2011;Samuels and Hen, 2011), while others report a dissociation between neurogenesis and behavioral changes (Henn and Vollmayr, 2004;Kovalenko et al, 2014). Taken together, the data seem to suggest that neurogenesis-independent mechanisms (David et al, 2009) are likely to be involved in the rescue of cognitive impairment and anxiogenic responses in IUGR female rats that are due to adolescent exposure to SDS.…”

Section: A) Elevated Plus Maze B) T-mazementioning

confidence: 66%

“…In addition, adult rats with IUGR induced by prenatal dietary restriction exhibit increased neurogenesis in the hippocampus, and acute restraint stress does not affect this change in neurogenesis (Uban et al, 2010). The correlation between the stress-induced reduction of hippocampal neurogenesis and impaired behavioral responses is well-documented in normal subjects (McCormick et al, 2010;Ming and Song, 2011;Samuels and Hen, 2011), raising the question of whether stress causes deterioration in the behavioral responses of IUGR individuals.…”

Section: Introductionmentioning

confidence: 97%

Exposure to social defeat stress in adolescence improves the working memory and anxiety-like behavior of adult female rats with intrauterine growth restriction, independently of hippocampal neurogenesis

Furuta

Ninomiya-Baba

Chiba

et al. 2015

Hormones and Behavior

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“…In rats and mice, social stressors, or even disruption of social activities at this time, have been found to produce a variety of later alterations in behaviour, central neural and neurochemical activity, as well as neuroendocrine stress responses [66][67][68][69].…”

Section: The Shaping Of Behavioural Profiles During Adolescencementioning

confidence: 99%

Behavioural profiles are shaped by social experience: when, how and why

Sachser

Kaiser

Hennessy

2013

Phil. Trans. R. Soc. B

138

158

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The comprehensive understanding of individual variation in behavioural profiles is a current and timely topic not only in behavioural ecology, but also in biopsychological and biomedical research. This study focuses on the shaping of behavioural profiles by the social environment in mammals. We review evidence that the shaping of behavioural profiles occurs from the prenatal phase through adolescence and beyond. We focus specifically on adolescence, a sensitive phase during which environmental stimuli have distinctive effects on the modulation of behavioural profiles. We discuss causation, in particular, how behavioural profiles are shaped by social stimuli through behavioural and neuroendocrine processes. We postulate a central role for maternal hormones during the prenatal phase, for maternal behaviour during lactation and for the interaction of testosterone and stress hormones during adolescence. We refer to evolutionary history and attempt to place developmental shaping into broader evolutionary historical trends. Finally, we address survival value. We argue that the shaping of behavioural profiles by environmental stimuli from the prenatal phase through adolescence represents an effective mechanism for repeated and rapid adaptation during the lifetime. Notably, the adolescent phase may provide a last chance for correction if the future environment deviates from that predicted in earlier phases.

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Hippocampal cell proliferation and spatial memory performance after social instability stress in adolescence in female rats

Cited by 74 publications

References 83 publications

Social instability stress in adolescent male rats alters hippocampal neurogenesis and produces deficits in spatial location memory in adulthood

Social instability stress in adolescent male rats alters hippocampal neurogenesis and produces deficits in spatial location memory in adulthood

Exposure to social defeat stress in adolescence improves the working memory and anxiety-like behavior of adult female rats with intrauterine growth restriction, independently of hippocampal neurogenesis

Behavioural profiles are shaped by social experience: when, how and why

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