Hippocampal Connectivity of the Presubiculum in the Common Marmoset (Callithrix jacchus)

Honda, Yoshiyuki; Shimokawa, Tetsuya; Matsuda, Seiji; Kobayashi, Yasushi; Moriya-Ito, Keiko

doi:10.3389/fncir.2022.863478

Cited by 4 publications

(3 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The involvement of all layers suggests ongoing bidirectional communication between pre/parasubiculum and PHC despite the omission of the bottom-up input. While the subiculum proper is the primary output subfield of the hippocampus [21,46,47], the pre/parasubiculum plays a dual role, both sending information out of the hippocampus but also acting as the primary target for visuospatial information sent to the hippocampus [48][49][50][51][52][53]. Therefore, it is unclear exactly what purpose the communication between pre/parasubiculum and PHC serves during omission trials.…”

Section: Discussionmentioning

confidence: 99%

Communication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortex

Warrington,

Graedel,

Callaghan

et al. 2024

Preprint

View full text Add to dashboard Cite

Current evidence points to the hippocampus as an essential region coordinating learning and exploiting predictive relationships in the service of perception. However, it remains unclear whether the hippocampus drives the communication of predictions to the sensory cortex or acts as a recipient of predictions from elsewhere. Here, we collected sub-millimetre 7T fMRI data to investigate neural signals in the medial temporal lobe (MTL). We used layer-specific fMRI to infer the direction of communication between the hippocampus and cortex. Specifically, superficial layers of the MTL cortex project to the hippocampus, while deep MTL layers receive feedback projections. Participants performed a task in which auditory cues predicted abstract shapes. Crucially, we omitted the expected shape on 25% of trials, thus isolating the prediction signal from bottom-up input and allowing us to ask: In which direction are predictions communicated between the hippocampus and neocortex? Neural patterns in CA23, pre/parasubiculum and the parahippocampal cortex (PHC) reflected shape-specific predictions. Layer-specific informational connectivity analyses revealed that communication between CA23 and PHC was specific to the deep layers of PHC. These findings are in line with the hippocampus generating predictions through pattern completion in CA23 and feeding these predictions back to the neocortex.

show abstract

Section: Discussionmentioning

confidence: 99%

Communication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortex

Warrington,

Graedel,

Callaghan

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Conversely, while the subiculum proper is the main output region of the hippocampus, the pre/para-subiculum is primarily an input region, receiving input from areas including the subiculum proper, CA1, RSC and inferior parietal cortex (Honda & Shibata, 2017; Honda et al, 2022; Huang et al, 2021; Insausti & Munoz, 2001; Kravitz et al, 2011). A parieto-medial pathway originates in visuospatial regions of the parietal cortex, and connects to the parahippocampal cortex and RSC (Dalton & Maguire, 2017; Kravitz et al, 2011), two areas known to contribute to spatial processing (Cukur et al, 2016; Epstein et al, 2017; Hodgetts et al, 2016; Nasr et al, 2013), which in turn connect directly with the pre/para-subiculum (Dalton & Maguire, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…These interconnected structures are key components of an extended hippocampal system thought to support spatial attributes of memory (Aggleton, 2012; see also Murray et al, 2017) as well as contributing to complex scene discrimination (Postans et al, 2014;Hodgetts et al, 2015). The subiculum proper, at least in rodents, also appears to contain several types of spatially-modulated neurons, including cells attuned to spatial position (Sharp, 2006), boundaries (Lever et al, 2009), corners (Sun et al, 2023) and direction of travel (Olson et al, 2017), as well as cells that seemingly fire conjunctively for several such properties needed to re-construct representations of spatial environments (Ledergerber et al, 2021;Sharma et al, 2022) Conversely, while the subiculum proper is the main output region of the hippocampus, the pre/para-subiculum is primarily an input region, receiving input from areas including the subiculum proper, CA1, RSC and inferior parietal cortex (Honda & Shibata, 2017;Honda et al, 2022;Huang et al, 2021;Insausti & Munoz, 2001;Kravitz et al, 2011). A parieto-medial pathway originates in visuospatial regions of the parietal cortex, and connects to the parahippocampal cortex and RSC (Dalton & Maguire, 2017;Kravitz et al, 2011), two areas known to contribute to spatial processing (Cukur et al, 2016;Epstein et al, 2017;Hodgetts et al, 2016;Nasr et al, 2013), which in turn connect directly with the pre/para-subiculum (Dalton & Maguire, 2017).…”

Section: Group-level Analysis Demonstrates a Scene-processing Pathway...mentioning

confidence: 99%

Scene-selectivity in CA1/subicular complex: Multivoxel pattern analysis at 7T

Read,

Berry,

Graham

et al. 2023

Preprint

View full text Add to dashboard Cite

Prior univariate functional magnetic resonance imaging (fMRI) studies in humans suggest that the anteromedial subicular complex of the hippocampus is a hub for scene-based cognition. However, it is possible that univariate approaches were not sufficiently sensitive to detect scene-related activity in other subfields that have been implicated in spatial processing (e.g., CA1). Further, as connectivity-based functional gradients in the hippocampus do not respect classical subfield boundary definitions, category sensitivity may be distributed across anatomical subfields. Region-of-interest approaches, therefore, may limit our ability to observe category selectivity across discrete subfield boundaries. To address these issues, we applied searchlight multivariate pattern analysis to 7T fMRI data of healthy adults who undertook a simultaneous visual odd-one-out discrimination task for scene and non-scene (including face) visual stimuli, hypothesising that scene classification would be possible in multiple hippocampal regions within, but not constrained to, anteromedial subicular complex and CA1. Indeed, we found that the scene-selective searchlight map overlapped not only with anteromedial subicular complex (distal subiculum, pre/para subiculum), but also inferior CA1, alongside retrosplenial and parahippocampal cortices. Probabilistic overlap maps revealed gradients of scene category selectivity, with the strongest overlap located in the medial hippocampus, converging with searchlight findings. This was contrasted with gradients of face category selectivity, which had stronger overlap in more lateral hippocampus, supporting ideas of parallel processing streams for these two categories. Our work helps to map the scene, in contrast to, face processing networks within, and connected to, the human hippocampus.

show abstract

Connectivity of the Claustrum–Endopiriform Complex with the Presubiculum and Hippocampal Regions in the Common Marmoset (Callithrix jacchus)

Honda,

Moriya‐Ito,

Shimokawa

et al. 2024

J of Comparative Neurology

View full text Add to dashboard Cite

We have investigated the hippocampal connectivity of the marmoset presubiculum (PreS) and reported that major connections of PreS in the rat were conserved in the marmoset. Moreover, our results indicated the presence of several additional projections that were almost absent in the rat brain, but abundant in the marmoset, such as direct projections from CA1 to PreS. However, little is known about the connectivity between the frontal brain regions and PreS or hippocampal formation. Therefore, we investigated the distribution of cells of the origins and terminals of the presubicular and hippocampal projections in the marmoset frontal brain regions using the retrograde and anterograde tracer cholera toxin B subunit. In cases of tracer injections into all layers of PreS, many neurons and terminals were labeled in the claustrum–endopiriform (Cl–En) complex almost entirely along the rostrocaudal axis. Even in cases where the injection site involved the superficial (not deep) layers of PreS, labeled neurons and terminals were distributed over a wide rostrocaudal range of the Cl–En complex, but their number and density were significantly lower than the whole‐layer injection cases. In cases where the injection site was confined to the hippocampal formation, labeled cells and terminals were localized at a restricted portion of the Cl–En complex. Here, we demonstrate for what we believe to be the first time the strong, reciprocal connections of the Cl–En complex with PreS and projections from the Cl–En complex to the hippocampal regions (CA1 and the subiculum) in the marmoset. Our findings indicate that the Cl–En complex may exert a strong influence on the cortical and subcortical outputs from PreS and, in turn, the entire memory circuitry in the marmoset brain.

show abstract

Hippocampal Connectivity of the Presubiculum in the Common Marmoset (Callithrix jacchus)

Cited by 4 publications

References 38 publications

Communication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortex

Communication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortex

Scene-selectivity in CA1/subicular complex: Multivoxel pattern analysis at 7T

Connectivity of the Claustrum–Endopiriform Complex with the Presubiculum and Hippocampal Regions in the Common Marmoset (Callithrix jacchus)

Contact Info

Product

Resources

About