Hippocampal correlates of episodic memory in Parkinson’s disease: A systematic review of magnetic resonance imaging studies

Pourzinal, Dana; Yang, Ji Hyun J.; Bakker, Arnold; McMahon, Katie L.; Byrne, Gerard J.; Pontone, Gregory M.; Mari, Zoltan; Dissanayaka, Nadeeka N.

doi:10.1002/jnr.24863

Cited by 9 publications

(11 citation statements)

References 95 publications

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“…Thus, although the role of the hippocampus in episodic memory and cognitive decline in PD is well-established (Pourzinal et al, 2021), further exploration of the functional and structural integrity of the fusiform gyrus as a potential biomarker for cognitive decline in PD is necessary.…”

Section: Discussionmentioning

confidence: 99%

“…Although the posterior-cortical subtype demonstrated visual memory impairment in the present study, no correlations were revealed between visual memory or other visuospatial measures and fusiform-hippocampal connectivity values. However, studies have linked verbal memory, semantic memory, visuospatial impairments to brain atrophy, and cognitive decline in PD (Pelletier et al, 2017;Pourzinal et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

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Hippocampal resting‐state connectivity is associated with posterior‐cortical cognitive impairment in Parkinson's disease

Pourzinal,

Yang,

McMahon

et al. 2024

Brain and Behavior

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AimFrontal and posterior‐cortical cognitive subtypes in Parkinson's disease (PD) present with executive/attention and memory/visuospatial deficits, respectively. As the posterior‐cortical subtype is predicted to progress rapidly toward dementia, the present study aimed to explore biological markers of this group using resting‐state functional magnetic resonance imaging (rs‐fMRI).MethodsK‐means cluster analysis delineated subtypes (cognitively intact, frontal, posterior‐cortical, and globally impaired) among 85 people with PD. A subset of PD participants (N = 42) and 20 healthy controls (HCs) underwent rs‐fMRI. Connectivity of bilateral hippocampi with regions of interest was compared between posterior‐cortical, cognitively intact, and HC participants using seed‐based analysis, controlling for age. Exploratory correlations were performed between areas of interest from the group analysis and a series of cognitive tests.ResultsThe posterior‐cortical subtype (N = 19) showed weaker connectivity between the left hippocampus and right anterior temporal fusiform cortex compared to the cognitively intact (N = 11) group, p‐false discovery rate (FDR) = .01, and weaker connectivity between bilateral hippocampi and most fusiform regions compared to HCs (N = 20). No differences were found between HCs and cognitively intact PD. Exploratory analyses revealed strongest associations between connectivity of the right anterior temporal fusiform cortex and left hippocampus with category fluency (p‐FDR = .01).ConclusionResults suggest that weakened connectivity between the hippocampus and fusiform region is a unique characteristic of posterior‐cortical cognitive deficits in PD. Further exploration of hippocampal and fusiform functional integrity as a marker of cognitive decline in PD is warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hippocampal resting‐state connectivity is associated with posterior‐cortical cognitive impairment in Parkinson's disease

Pourzinal,

Yang,

McMahon

et al. 2024

Brain and Behavior

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“…Hence, evidence suggests that memory dysfunction in individuals with PD may reflect hippocampal alterations rather than solely fronto-striatal alterations. Neuroimaging studies provide support for this position by demonstrating associations between hippocampal alterations in PD and memory dysfunction (see Pourzinal et al, 2021 for a review).…”

Section: Introductionmentioning

confidence: 96%

Face name matching and memory complaints in Parkinson’s disease

Siquier

Andrés

2022

Front. Psychol.

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ObjectiveMemory impairment is a hallmark cognitive deficit in Parkinson’s disease (PD). However, it remains unclear which processes underlie this deficit in PD. Also, little is known on these patients’ subjective experiences of memory difficulties and their relationship with objective measures. We aim to portray memory deficits in PD by combining objective and subjective memory measures.MethodsFifteen PD patients and 15 controls were assessed with an extended version of the Face-Name Associative Memory Exam (FNAME) and the Memory Failures of Everyday Questionnaire (MFE-28). We also explored the relationship among clinical and cognitive variables.ResultsParticipants with PD presented with more memory complaints. On the FNAME, these patients exhibited lower performance in free recall, as well as in name recognition and matching. Importantly, when controlling for initial learning, group effects disappeared, except for matching. Associative memory therefore was significantly compromised in PD and correlated with subjective memory complaints (SMC).ConclusionOur findings suggest that associative memory may constitute a sensitive measure to detect subtle memory deficits in PD. Moreover, the current study further clarifies the source of memory impairment in PD. Thus, our study highlights the clinical value of including associative memory tests such as the FNAME in PD neuropsychological assessment.

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“…The third review, mainly focused on the correlation between the hippocampal and episodic memory. They provided evidence for the significance of the hippocampus's structural and functional integrity in episodic memory impairment in PD-NC [14]. While the fourth literature review explored the neuroimaging correlation between PD-NC patients and Mild Cognitive Impairment (PD-MCI).…”

Section: Introductionmentioning

confidence: 99%

Neuroimaging and Neuropsychological Performance in Parkinson's Disease Patients with Normal Cognition: A Systematic Review

Alanazi,

Albakheit,

Alzahrani

2023

J. Pharm. Res. Int.

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Introduction: Cognitive decline is one of Parkinson's disease's (PD) non-motor symptoms that is most frequently observed. Patients with PD exhibit quick cognitive decline in a variety of cognitive domains, particularly in the areas of executive functions, attention, language, memory, and visuospatial abilities. The scope of PD patients with normal cognition (PD-NC) and its relationship to specific regions of the brain as shown by neuroimaging, have not received much attention in the literature. Objective: This review was to summarise the existing literature that explored cognitive performance in PD-NC using different neuroimaging techniques. Methods: A comprehensive search was conducted on PubMed and Web of Science databases. This review focused on papers that investigated neuroimaging and neuropsychological performance in patients with PD. A total of 17 articles have met the criteria. Results: The findings of this review were that executive functions appear to be the most critical cognitive domain to be damaged in PD-NC. Global cognitive ability was found to have insignificant decline overall between PD-NC and healthy controls (HC). Attention and executive functions were associated with the prefrontal cortex. Memory was mainly associated with hippocampal atrophy. Language was associated with cerebrospinal fluid and grey matter. Visuospatial ability was associated with the anterior cingulate cortex. Conclusion: This review illustrated that PD-NC seemed to experience different cognitive patterns and neuroanatomical changes compared with HC. These results suggested that PD-NC may develop specific cognitive impairments associated with specific brain regions. Therefore, it indicated that PD-NC may need to have specific treatments tailored to their needs.

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Hippocampal correlates of episodic memory in Parkinson’s disease: A systematic review of magnetic resonance imaging studies

Cited by 9 publications

References 95 publications

Hippocampal resting‐state connectivity is associated with posterior‐cortical cognitive impairment in Parkinson's disease

Hippocampal resting‐state connectivity is associated with posterior‐cortical cognitive impairment in Parkinson's disease

Face name matching and memory complaints in Parkinson’s disease

Neuroimaging and Neuropsychological Performance in Parkinson's Disease Patients with Normal Cognition: A Systematic Review

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